6625-96-3,6625-96-3, 5-Nitro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of Ph3PCHCOOEt (2.07 g, 5.97 mmol, 1.15 eq) in dry toluene (15 ml) was added, via cannula, to a suspension of 3-carboxaldehyde-5-nitroindole XV (987 mg, 5.19 mmol, 1 eq) in dry toluene (49 ml). The resulting suspension was heated at reflux under argon atmosphere until disappearance of starting material (about 2h) (TLC, hexane/acetone=6:4). The solvent was removed at reduced pressure and the crude was purified by flash chromatography (hexane/AcOEt=5:5) to afford the title compound XVI (1.34 g, mixture of isomers E/Z 9/1, quantitative yield). 1H-NMR (400 MHz, CDCl3) delta ppm 1.38 (t, J=7 Hz, 3 H) 4.30 (q, J=7 Hz, 3 H) 6.53 (d, J=16.1 Hz, 1 H) 7.48 (d, J=9 Hz, 1 H) 7.64 (d, J=2.7 Hz, 1 H) 7.88 (d, J=16.1 Hz, 1 H) 8.20 (dd, J= 9, 1.9 Hz, 1 H) 8.86 (d, J=1.9 Hz, 1 H) 8.93 (broad, 1 H).
As the paragraph descriping shows that 6625-96-3 is playing an increasingly important role.
Reference£º
Patent; Nerviano Medical Sciences S.r.l.; EP2003129; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles