With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.679794-03-7,6-Bromo-1-(phenylsulfonyl)-1H-indole,as a common compound, the synthetic route is as follows.,679794-03-7
General procedure: To a stirred solution of 6 (1 mmol) in anhydrous THF (10 ml) at -78 ¡ãC was added a solution of LDA (1.5 mmol) in THF (5 ml). The mixture was stirred for at -78 ¡ãC for 100 min and then warmed to 0 ¡ãC for 30 min. The solution was re-cooled to -78 ¡ãC and then either a solution of 1,2-diiodo ethane or molecular iodine (1.5 mmol) in THF (10 ml) was added. The reaction mixture was stirred at 0 ¡ãC for 15 min and then allowed for warm to room temperature for 1 h. The reaction was quenched with saturated NH4Cl solution and extracted with EtOAc (2 * 50 ml). The combined organic phases were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by automated flash chromatography using EtOAc and hexanes as eluents to give the desired product.
The synthetic route of 679794-03-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kumar, Nag S.; Dullaghan, Edie M.; Finlay, B. Brett; Gong, Huansheng; Reiner, Neil E.; Jon Paul Selvam; Thorson, Lisa M.; Campbell, Sara; Vitko, Nicholas; Richardson, Anthony R.; Zoraghi, Roya; Young, Robert N.; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1708 – 1725;,
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