6958-37-8,6958-37-8, 5-Nitro-1H-indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-nitroindole-3-carboxylic acid (2.45 g, 12 mmol) in methanol (50 cm3) was added sulphuric acid (1 cm3) and the solution stirred at reflux for 6 hours. The solution was allowed to cool and then poured onto ice-water, neutralised with sodium bicarbonate and the product filtered to give a yellow solid, which was recrystallised from methanol as an off-white solid. Yield 1.76 g, 67%. mp 282-2840C. deltaH 3.85 (3H, s, OCH3), 7.65 (IH, d, J 9, H7), 8.08 (IH, dd, Ji 9, J2 2.3, H6), 8.35 (IH, s, H2), 8.83 (IH, d, J 2.3, H4), 8.5 (IH, s, NH). uv lambdamax/nm 320 (15000), 251 (32450), lambdamin/nm 284, 213; pH 12 lambdamax/nm 366 (13100), 271 (31500), 213 (48100). m/z 243.1 (M+Na)+. Accurate mass measurement on (M+Na)+ Ci0H8N2O4Na 243.0396, deviation -5.73 ppm.
6958-37-8 5-Nitro-1H-indole-3-carboxylic acid 248136, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; MEDICAL RESEARCH COUNCIL; WO2007/135380; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles