Category: 703-80-0

703-80-0, 3-Acetylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

703-80-0, A solution of 0.80 g (5 mmol) of 3-acetylindole in 30 mL of dry THF was added and 0.4 g (2 eq) of NaH in an amount of 60% was added to the flask at 0 C. The mixture was stirred for 15 minutes and 1.3 mL (2 eq) CH3I, the reaction was gradually warmed to room temperature, the reaction 2 hours,TLC showed the disappearance of raw materials; 0 C slowly added ice water to quench the reaction, extracted 2-3 times with ethyl acetate, saturated sodium chloride solutionWashed once, dried over anhydrous sodium sulfate, and evaporated under reduced pressure to obtain 0.73g white solid1- (1-methyl-1H-indol-3-yl) ethanone,Yield: 92.0%.

As the paragraph descriping shows that 703-80-0 is playing an increasingly important role.

Reference£º
Patent; Hebei University of Science and Technology; Zhang Zhiwei; Li Hailing; Liu Shouxin; Dong Yu; Feng Juan; Li Junzhang; (20 pag.)CN106977515; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.703-80-0,3-Acetylindole,as a common compound, the synthetic route is as follows.

703-80-0, To a solution of 3-acetylindole 8a (1.0 g, 6.3 mmol) in THF (5.0 mL) sodium hydride (60% dispersion in mineral oil, 0.3 g, 6.3 mmol) was added at 0 C and the mixture was stirred at room temperature for 1 h. p-toluenesulfonyl chloride (1.2 g, 6.3 mmol) was added and the mixture was stirred at room temperature for 24 h. The residue was evaporated under reduced pressure, treated with water (20 mL) and extracted with EtOAc (3 ¡Á 20 mL). The organic phase was dried (Na2SO4), evaporated under reduced pressure and purified by column chromatography using DCM as eluent. White solid; yield: 90%; mp: 148-149 C; IR 1662 (CO), 1382, 1299 (SO2) cm-1; 1H NMR (200 MHz, DMSO-d6) delta: 2.33 (s, 3H, CH3), 2.60 (s, 3H, CH3), 7.32-7.39 (m, 2H, H-5, H-6), 7.43 (d, 2H, J = 7.8 Hz, H-3?, H-5?), 7.95 (d, 1H, J = 7.5 Hz, H-7), 8.04 (d, 2H, J = 7.8 Hz, H-2?, H-6?), 8.19 (d, 1H, J = 7.5 Hz, H-4), 8.81 (s, 1H, H-2); 13C NMR (50 MHz, DMSO-d6) delta:21.0 (q), 27.8 (q), 113.0 (d), 120.7 (s), 122.3 (d), 124.8 (d), 125.6 (d), 127.0 (s), 127.2 (2xd), 130.5 (2xd), 133.5 (s), 134.0 (s), 134.2 (d), 146.2 (s), 193.9 (s). Anal. Calcd for: C17H15NO3S: C, 65.16; H, 4.82; N, 4.47. Found: C, 65.28, H, 5.06, N, 4.37.

703-80-0 3-Acetylindole 12802, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Parrino, Barbara; Carbone, Anna; Di Vita, Gloria; Ciancimino, Cristina; Attanzio, Alessandro; Spano, Virginia; Montalbano, Alessandra; Barraja, Paola; Tesoriere, Luisa; Livrea, Maria Antonia; Diana, Patrizia; Cirrincione, Girolamo; Marine Drugs; vol. 13; 4; (2015); p. 1901 – 1924;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles