Category: 7254-19-5

7254-19-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7254-19-5,5-Bromo-1H-indole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 5-Bromo-1H-indole-2-carboxylic acid (commercial, 10.0 g, 41.6 mmol) in methanol (200 ml) was cooled to 0 C and saturated with HCI (g).. The resulting solution was allowed to warm gradually to room temperature overnight.. The solvent was removed in vacuo and the residue treated with 0.88 ammonia (500 ml).. The resulting solution was extracted with dichloromethane (3-fold 150 ml) and the combined organics dried (magnesium sulphate) and the solvent removed in vacuo to give the required product as a colourless oil (8.35 g).1H NMR (400MHz, CDCl3): delta = 8.96 (1H, bs), 7.83 (1H, s), 7.40 (1H, d), 7.30 (1H, d), 7.14 (1H, s), 3.95 (3H, s). LRMS (electrospray): m/z [M-H]- 252 / 254.

7254-19-5 5-Bromo-1H-indole-2-carboxylic acid 252137, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Pfizer Limited; EP1460064; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

7254-19-5, 5-Bromo-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7254-19-5

Example 20 Preparation of 4S-[(5-bromo-1H-indole-2-carbonyl)-amino]-5-(2-oxo-pyrrolidin-3S-yl)-pent-2-enoic Acid Compound 20 was prepared according to the method of Example 1, using 5-bromo-2-indolecarboxylic acid. 1H NMR (CDCl3) delta9.94 (1H, s), 8.94 (1H, d, J=5.9), 7.73 (1H, s), 7.30 (2H, s), 7.07 (1H, d, J=1.8) 6.95 (1H, dd, J=15.6, 5.3), 6.42 (1H, s), 6.03 (1H, dd, J=15.6, 1.4), 4.80-4.65 (1H, m), 4.17 (2H, q, J=7.1), 3.45-3.35 (2H, m), 2.70-2.55 (1H, m), 2.50-2.38 (1H, m), 2.15-1.78 (3H, m), 1.27 (3H, t, J=7.1). MS (FAB) 448.0858 (MH+, calcd 448.0872), 470 (MNa+).

The synthetic route of 7254-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Johnson, Jr., Theodore O.; Chu, Shao Song; Eastman, Brian Walter; Hua, Ye; Luu, Hiep The; Reich, Siegfried Heinz; Skalitzky, Donald James; Yang, Yi; Hendrickson, Thomas F.; Chan, Fora P.; US2002/61916; (2002); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles