Category: 74339-45-0

In 2020,Heterocycles included an article by Tabata, Mutsuko; Oshikiri, Naoki; Hasegawa, Masakazu; Satoh, Keiichi; Fukui, Yoshikazu; Nagahama, Yoshiyuki; Morikawa, Harunobu; Yamada, Fumio; Somei, Masanori. Quality Control of Methyl 2-(5-chloro-1H-indol-3-yl)acetate. The article was titled 《1-hydroxyindoles: production of feruloylserotonin, an alkaloid of safflower seed, novel ring system compound, 1,10-diaza-9,20-dioxokabutanes, 2,2′-bisindoles, and (dl)-3a,3a’-bispyrrolo[2,3-b]indoles》. The information in the text is summarized as follows:

Me 1-hydroxyindole-3-acetate produced novel hexacyclic 8,17-bis(methoxycarbonylmethyl)-1,10-diaza-9,20-dioxakabutane as a major product by the reaction with 85% formic acid, while its reaction with trifluoroacetic acid generated exclusively another 2,2′-bisindole dimer, 1-hydroxy-3,3′-di(methoxycarbonylmethyl)-2,2′-bisindole. Reaction of Me 1-hydroxyindole-3-acetate with mineral acid such as HCl afforded Me 5-chloroindole-3-acetate, products and their distribution changed depending on the structure of 1-hydroxyindole. The side chain has a C-C-N structure, enables nucleophilic substitution reaction to occur effectively, and was applied for the preparation of N-feruloylserotonin, an alkaloid isolated from safflower seed. 1-Hydroxymelatonin, having a methoxy group on the benzenoid part, afforded (dl)-3a,3a’-bis(pyrrolo[2,3-b]indole) compound by the treatment with 85% formic acid. Products’ structures are unequivocally determined by X-ray single crystallog. analyses. In the experiment, the researchers used Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0Quality Control of Methyl 2-(5-chloro-1H-indol-3-yl)acetate)

Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of Methyl 2-(5-chloro-1H-indol-3-yl)acetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gilbert, Eric J.; Ziller, Joseph W.; Van Vranken, David L. published their research in Tetrahedron on December 1 ,1997. The article was titled 《Cyclizations of unsymmetrical bis-1,2-(3-indolyl)ethanes: synthesis of (-)-tjipanazole F1》.Computed Properties of C11H10ClNO2 The article contains the following contents:

The inter- and intramol. dimerization of 3-substituted indoles was studied. The rate and extent of dimerization depends on the indole substituents. The intramol. dimerization of unsym. bis-1,2-(3-indolyl)ethanes could be controlled using either thermodn. reaction conditions (neat trifluoroacetic acid) or kinetic conditions (2 equiv acid/chloroform). This control of regiochem. has been applied to an efficient synthesis of (-)-tjipanazole F1. In addition to this study using Methyl 2-(5-chloro-1H-indol-3-yl)acetate, there are many other studies that have used Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0Computed Properties of C11H10ClNO2) was used in this study.

Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C11H10ClNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Determination of 4-chloroindole-3-acetic acid methyl ester in Lathyrus, Vicia and Pisum by gas chromatography-mass spectrometry》 was written by Engvild, Kjeld C.; Egsgaard, Helge; Larsen, Elfinn. Name: Methyl 2-(5-chloro-1H-indol-3-yl)acetate And the article was included in Physiologia Plantarum on April 15 ,1980. The article conveys some information:

4-Chloroindole-3-acetic acid Me ester was identified unequivocally in L. latifolius, V. fava, and P. sativum by thin-layer chromatog., gas chromatog., and mass spectrometry. The gas chromatog. system was able to sep. underivatized chloroindole-3-acetic acid Me ester isomers. The quant. determination of 4-chloroindole-3-acetic acid Me ester in immature seeds of these 3 species was performed by gas chromatog.-mass spectrometry using deuterated 4-chloro-indole-3-acetic acid Me ester as an internal standard P. sativum Contained ∼25, V. fava 1-2, and L. latifolius 2 mg/kg dry weight In addition to this study using Methyl 2-(5-chloro-1H-indol-3-yl)acetate, there are many other studies that have used Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0Name: Methyl 2-(5-chloro-1H-indol-3-yl)acetate) was used in this study.

Methyl 2-(5-chloro-1H-indol-3-yl)acetate(cas: 74339-45-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: Methyl 2-(5-chloro-1H-indol-3-yl)acetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles