Category: 76-60-8

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Development and validation of spectrophotometric methods for determination of leukotriene receptor antagonist montelukast sodium in bulk and pharmaceutical formulations, the main research direction is leukotriene receptor antagonist montelukast sodium bulk pharmaceutical formulation spectrophotometry.Computed Properties of C21H14Br4O5S.

Objective: Simple, sensitive, precise, reproducible, and validated visible spectrophotometric methods have been developed for the determination of leukotriene receptor antagonist drug, namely, montelukast (MNT) sodium in bulk and pharmaceutical preparations Methods: Three spectrophotometric methods are based on the formation of yellow-colored ion-pair complexes between MNT sodium and three dyes, bromocresol green, bromophenol blue, and methyl orange with absorption maxima at 420, 416, and 426 nm, resp. Results: The stoichiometric ratio of the formed ion-pair complexes was found to be 1:1 (drug:reagent) for all methods, as deduced by Job’s method of continuous variation. Several parameters such as pH, buffer type and volume, reagent volume, sequence of addition, and effect of extracting solvent were optimized to achieve high sensitivity, stability, low blank reading, and reproducible results. Under the optimum conditions, linear relationships with good correlation coefficients (0.9993-0.9999) were found over the concentration ranges of 1.0-10, 1.0-12, and 1.0-16μg/mL with a limit of detection of 0.30, 0.29, and 0.27μg/mL for bromocresol green, bromophenol blue, and methyl orange methods, resp. Conclusion: The proposed methods were validated in accordance with ICH guidelines and successfully applied to the anal. of MNT sodium in pharmaceutical formulations. Statistical comparison of the results obtained by applying the proposed methods with those of the reference method revealed good agreement and proved that there was no significant difference in the accuracy and precision between the results.

In some applications, this compound(76-60-8)Computed Properties of C21H14Br4O5S is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mabrouk, M. M.; Gouda, A. A.; El-Malla, S. F.; Abdel Haleem, D. S. published an article about the compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8,SMILESS:CC1=C(Br)C(O)=C(Br)C=C1C2(C3=CC(Br)=C(O)C(Br)=C3C)C4=CC=CC=C4S(O2)(=O)=O ).Product Details of 76-60-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:76-60-8) through the article.

The developed methods are based on the formation of ion-pair complexes between vardenafil HCl and dyes, namely, bromocresol green (BCG), bromocresol purple (BCP), bromophenol blue (BPB), bromothymol blue (BTB) and eriochrom black T (EBT) in acidic buffer solutions Different factors affecting the reactions between VARD and the dyes were studied and optimized. The formed complexes were extracted with methylene chloride and measured at 418, 410, 415, 417 and 520 nm using BCG, BCP, BPB, BTB and EBT, resp. The beer’s law was obeyed in the ranges 1.0-10, 1.0-16, 0.5-8.0, 2.0-20 and 1.0-14μg mL-1 for BCG, BCP, BPB, BTB and EBT, resp. under the optimum conditions. The composition of the ion-pairs was found 1:1. The molar absorptivity’s, Sandell’s sensitivity, limits of detection and the limits of quantification were calculated Other method validation parameters, such as accuracy, intra-day and inter-day precision, robustness, ruggedness and selectivity, have been evaluated. The proposed methods have been applied successfully for the anal. of vardenafil HCl in pure and dosage forms. The reliability of the methods was further ascertained by performing recovery studies using the standard addition method. Statistical comparison of the results with the reported method was performed by applying student’s t- and F-tests and no significant statistical differences were obtained.

In some applications, this compound(76-60-8)Product Details of 76-60-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Synthesis of coral-like α-Fe2O3 nanoparticles for dye degradation at neutral pH. Author is Gupta, Nishesh Kumar; Ghaffari, Yasaman; Bae, Jiyeol; Kim, Kwang Soo.

This study reported a surfactant-mediated synthesis of coral-like α-Fe2O3 nanoparticles (FONP) via a simple co-precipitation-oxidation route. The synthesized FONP photocatalyst had a hexagonal morphol., as observed in the transmission electron micrographs. A surface area of 15 m2 g-1 was calculated from the N2 adsorption-desorption isotherm. The photocatalyst showed strong absorbance in the entire UV-Visible range with a low bandgap energy of 1.91 eV as estimated using the Tauc plot. The photocatalytic activity of FONP was evaluated by degrading several organic dyes at neutral pH. In the optimized exptl. conditions, the FONP photocatalyst showed fast degradation of Methylene blue (95%), Methyl orange (94%), Bromo green (94%), and Methyl red (76%) within 5 min in 32 W UV/H2O2 system. The reusability study showed a 10% loss in the degradation efficiency after five cycles. A possible photo-Fenton degradation mechanism was deduced based on scavenger studies.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reference of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Synthesis of BiPO4 by crystallization and hydroxylation with boosted photocatalytic removal of organic pollutants in air and water. Author is Wang, Yaxiao; Ye, Xiangju; Chen, Gongbin; Li, Danzhen; Meng, Sugang; Chen, Shifu.

Environmental photocatlytsis has been considered as a promising alternative strategy to address the current environmental threats and pressures. Fabrication of the photocatalysts with high efficiency, stability and bio-safety is the core of photocatalytic applications. Herein, we report a facile approach to synthesize monazite BiPO4 (SHTW) with high crystallization and hydroxylation. The wide bandgap of the SHTW can provide strong redox abilities to produce reactive species and mineralize organic pollutants. Its high crystallinity and dipole moment can promote separation and transportation of the photoexcited electron-hole pairs effectively. In addition, the hydroxylation can produce more highly oxidizing hydroxyl radicals and further improve charge carrier separation Notably, the hydroxylation can be reborn and the high crystallization can be maintained during photocatalysis. Thus, a virtuous cycle can be established and organic pollutants can be removed efficiently. The mineralization rate of 146.1μmol g-1 h-1 can be obtained on the SHTW for photocatalytic degradation of benzene, which is about 8.5 times higher than that of the com. TiO2 (P25). Various dyes, dyes mixture and bisphenol A can all be completely degraded over the SHTW. It shows the potential application and value in environmental governance.

In some applications, this compound(76-60-8)Reference of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Uzair, U.; Johnson, C.; Beladi, S.; Benza, D.; Raval, Y.; Ranasinghe, M.; Schober, G.; Tzeng, T.-R. J.; Anker, J. N. researched the compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8 ).Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide.They published the article 《Conformal coating of orthopedic plates with X-ray scintillators and pH indicators for X-ray excited luminescence chemical imaging through tissue》 about this compound( cas:76-60-8 ) in ChemRxiv. Keywords: orthopedic plate x ray scintillator pH indicator luminescence imaging. We’ll tell you more about this compound (cas:76-60-8).

The authors describe a material that allows for high spatial resolution pH mapping through tissue using x-ray excited luminescence chem. imaging (XELCI). This is especially useful for detecting implant associated infection and elucidating how the local biochem. environment changes during infection and treatment. To acquire one pixel in the image, a focused x-ray beam irradiates a small region of scintillators coated on the implant and the x-ray excited optical luminescence spectrum is modulated by indicator dyes to provide a chem. sensitive measurement with low background. Scanning the x-ray beam across the implant surface generates high spatial resolution chem. measurements. Two associated challenges are (1) to make robust sensors that can be implanted in tissue to measure local chem. concentrations and specifically for metal orthopedic implants, and (2) to conformally coat the implant surface with scintillators and pH indicator dyes to make measurements over a large area. Previously, the authors have phys. pressed or glued a pH-sensitive hydrogel sensor to the surface of an implant, but this is impractical for imaging over large irregular device areas such as an orthopedic plate with holes and edges. Herein the authors describe a chem. sensitive and biocompatible XELI sensor material containing scintillator particles (Gd2O2S:Eu) and a pH sensitive hydrogel coating using a roughened epoxy coating. A two-part com. grade epoxy film was tested and found to make the coating of pH sensitive layer adhere better to the titanium surface. Sugar and salt particles were added to the surface of the epoxy as it cured to create a roughened surface and increase surface area. On this roughened surface, a secondary layer of diacrylated polyethylene glycol (PEG) hydrogel, containing a pH sensitive dye, was polymerized This layer was found to adhere well to the epoxy-coated implant unlike other previously tested polymer surfaces which delaminated when exposed to water or humidity. The focused x-ray beam enabled 0.5 mm spatial resolution through 1 cm thick tissue. The pH sensor coated orthopedic plate was imaged with XELCI through tissue with different pH to acquire a calibration curve. The plates were also imaged through tissue with low pH region from a Staphylococcus aureus biofilm grown on one section. These studies demonstrate the use of pH sensor coated orthopedic plates for mapping the surface pH through tissue during biofilm formation using XELCI.

As far as I know, this compound(76-60-8)Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 76-60-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Revealing the local pH value changes of acidic aqueous zinc ion batteries with a manganese dioxide electrode during cycling. Author is Bischoff, Christian Friedrich; Fitz, Oliver Sebastian; Burns, Jordan; Bauer, Manuel; Gentischer, Harald; Birke, Kai Peter; Henning, Hans-Martin; Biro, Daniel.

The research on aqueous zinc ion batteries (AZIB) is getting more attention as the energy transition continues to develop and the need for inexpensive and safe stationary storage batteries is growing. As the detailed reaction mechanisms are not conclusively revealed, we want to take an alternative approach to investigate the importance of pH value changes during cycling. By adding a pH-indicator to the electrolyte (2 M ZnSO4 + 0.1 M MnSO4), the local pH-value change during operation is visualized in operando. The overall pH value was found to increase during cycling whereas a major temporary pH drop in close proximity of the manganese dioxide electrode surface occurs. Addnl., this pH value change was quantified locally by in operando measurements with a pH micro electrode. Different electrolyte compositions with additives (sodium dodecyl sulfate (SDS), sulfuric acid (H2SO4)) and operation voltages were tested. The pH-potential-diagrams of manganese and zinc reveal pH value and potential limits, leading to active material dissolution at lower pH values and oxygen gas evolution at higher potentials >1.7 V. The procedure of combining a pH indicator, pH microelectrode measurements and pH-potential diagrams can be seen as an appropriate method to determine the recommendable working window of aqueous batteries.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, is researched, Molecular C21H14Br4O5S, CAS is 76-60-8, about Printed sensor labels for colorimetric detection of ammonia, formaldehyde and hydrogen sulfide from the ambient air.

We present a novel method to monitor the exposure to toxic gases in ambient air based on a visible color change of a colorimetric gas sensor, which can be evaluated by the camera of a smartphone, stationary reader or even naked eye. This sensor consists of a disposable paper tag or plastic card and a gas sensitive material, which has been deposited by a screen-printing process. The integration of the gas sensitive layer into the machine-readable pattern of a QR-like code that incorporates color references for color calibration; makes it suitable for quant. as well as illumination and camera independent evaluation of the color change due to the reaction with the target gas. This work focusses on the development of printable pastes for the detection of ammonia , formaldehyde and hydrogen sulfide for the application in a colorimetric sensor label. NH3 and CH2O are detected with com. available pH sensitive color dyes. The alk. gas NH3 is tracked by the reaction with a pH indicator directly, while CH2O is detected by an intermediate reaction of CH2O with a primary amine through nucleophilic addition For the detection of H2S, an immobilized copper(II) complex of the azo dye 1-(2-pyridylazo)-2-naphtol (H-PAN) is synthesized. The color change of the printed sensors labels is characterized by the evaluation of RGB values taken with an in-situ readout station using a smartphone camera.

This literature about this compound(76-60-8)Safety of 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxidehas given us a lot of inspiration, and I hope that the research on this compound(3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 76-60-8, is researched, Molecular C21H14Br4O5S, about Influences of alcohol and diol on the aggregation behaviour, modes of interaction and the thermodynamic properties of the mixture of bromocresol green dye and sodium dodecyl sulphate at numerous temperatures, the main research direction is bromocresol green dye sodium dodecyl sulfate aggregation thermodn property.SDS of cas: 76-60-8.

The aggregation of the mixture of anionic surfactant – sodium dodecyl sulfate (SDS), and an anionic dye – bromocresol green sodium salt (BCG) was investigated by conductometric technique in water and alc./diolic media within a temperature range of 300.55-320.55 K (with 5 K interval). The observed critical micelle concentration (cmc) decreases with surging of the concentration of BCG, following the same trend for β value. In presence of additives (ethanol, propanol, and ethylene glycol), the cmc value decreases up to a certain concentration and then the cmc values start enhancing with increasing concentration in all the cases. With the increased additive percentage, the β values continually decrease. Again, the cmc value increases gradually with the increase of temperature both in water and aqueous additives media. The free energy of studied aggregation phenomena is neg. which experiences an augmentation with the escalation of temperature The increased neg. value of free energy at elevated temperature indicates that the process becomes more spontaneous at a higher temperature The and ΔH0m and ΔS0m values reveal that the probable interaction forces between BCG and SDS are hydrophobic, ion-ion, as well as electrostatic interactions.

In addition to the literature in the link below, there is a lot of literature about this compound(3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide)SDS of cas: 76-60-8, illustrating the importance and wide applicability of this compound(76-60-8).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8 ) is researched.Recommanded Product: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide.Abdullah, Ghassan H. published the article 《The impact of carbon dioxide and promotor concentrations on mass transfer characteristics in a bubble column reactor》 about this compound( cas:76-60-8 ) in Petroleum & Coal. Keywords: bubble column reactor carbon dioxide impact mass transfer. Let’s learn more about this compound (cas:76-60-8).

Developing a validated bubble column process that can be employed for design and optimization of the Benfield process is important to improve the process of gas sweetening in petrochem. process. In this work, the performance of chemisorption of carbon dioxide in amine promoted potassium carbo-nate solution in a bubble column reactor is studied using an electrochem. technique at different axial positions. Also, the effect of concentration of carbon dioxide and concentration of the promoter are investigated. It is found that the volumetric mass transfer coefficient increases rapidly for the same axial position with increasing carbon dioxide concentration For the solution studied, the volumetric mass transfer coefficient, KLa is higher than that in K2CO3 solution at the same operation conditions. It has been found that the local volumetric mass transfer coefficient is obviously varied with the axial position. The mass transfer coefficient also decreases with a ratio of probe-to- distributor distance, this reduction became more significant in the promoted solution due to shrinkage of the bubbles.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chedid, Carole; Kokhreidze, Eka; Tukvadze, Nestani; Banu, Sayera; Uddin, Mohammad Khaja Mafij; Biswas, Samanta; Russomando, Graciela; Acosta, Chyntia Carolina Diaz; Arenas, Rossana; Ranaivomanana, Paulo PR.; Razafimahatratra, Crisca; Herindrainy, Perlinot; Rakotonirina, Julio; Raherinandrasana, Antso Hasina; Rakotosamimanana, Niaina; Hamze, Monzer; Ismail, Mohamad Bachar; Bayaa, Rim; Berland, Jean-Luc; De Maio, Flavio; Delogu, Giovanni; Endtz, Hubert; Ader, Florence; Goletti, Delia; Hoffmann, Jonathan; The HINTT working Group within the GABRIEL network published an article about the compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide( cas:76-60-8,SMILESS:CC1=C(Br)C(O)=C(Br)C=C1C2(C3=CC(Br)=C(O)C(Br)=C3C)C4=CC=CC=C4S(O2)(=O)=O ).Recommanded Product: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:76-60-8) through the article.

Tuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon-γ (IFN-γ) release assay (IGRA) and QuantiFERON-TB Gold Plus (QFT-P) and to analyze plasma IFN-γ levels according to sputum culture conversion and immune cell counts during treatment. This multicentered cohort study was based in Bangladesh, Georgia, Lebanon, Madagascar, and Paraguay. Adult, non-immunocompromised patients with culture-confirmed pulmonary TB were included. Patients were followed up at baseline (T0), after two months of treatment (T1), and at the end of therapy (T2). Clin. data and blood samples were collected at each timepoint. Whole blood samples were stimulated with QFT-P antigens or recombinant methylated Mycobacterium tuberculosis HBHA (produced in Mycobacterium smegmatis; rmsHBHA). Plasma IFN-γ levels were then assessed by ELISA. Between Dec. 2017 and Sept. 2020, 132 participants completed treatment, including 28 (21.2%) drug-resistant patients. rmsHBHA IFN-γ increased significantly throughout treatment (0.086 IU/mL at T0 vs. 1.03 IU/mL at T2, p < 0.001) while QFT-P IFN-γ remained constant (TB1: 0.53 IU/mL at T0 vs. 0.63 IU/mL at T2, p = 0.13). Patients with low lymphocyte percentages (<14%) or high neutrophil percentages (>79%) at baseline had significantly lower IFN-γ responses to QFT-P and rmsHBHA at T0 and T1. In a small group of slow converters (patients with pos. cultures at T1; n = 16), we observed a consistent clin. pattern at baseline (high neutrophil percentages, low lymphocyte percentages and BMI, low TB1, TB2, and MIT IFN-γ responses) and low rmsHBHA IFN-γ at T1 and T2. However, the accuracy of the QFT-P and rmsHBHA IGRAs compared to culture throughout treatment was low (40 and 65% resp.). Combining both tests improved their sensitivity and accuracy (70-80%) but not their specificity (<30%). We showed that QFT-P and rmsHBHA IFN-γ responses were associated with rates of sputum culture conversion. Our results support a growing body of evidence suggesting that rmsHBHA IFN-γ discriminates between the different stages of TB, from active disease to controlled infection. However, further work is needed to confirm the specificity of QFT-P and rmsHBHA IGRAs for treatment monitoring. In addition to the literature in the link below, there is a lot of literature about this compound(3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide)Recommanded Product: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide, illustrating the importance and wide applicability of this compound(76-60-8).

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles