With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76644-74-1,1H-Isoindol-3-amine hydrochloride,as a common compound, the synthetic route is as follows.,76644-74-1
To a solution of 3-amino-1H-isoindole hydrochloride (3.25 g, 19.3 mmol) and 5-methyl-3-oxo-hexanoic acid methyl ester (3.35 g, 21.2 mmol) in MeOH (96 mL) was added a 30 wt % sodium methoxide solution in methanol (7.2 mL, 38.5 mmol). The mixture was stirred at room temperature overnight. The volatiles were evaporated and the solid material was washed with hexane/ether to give 3.4 g of 2-isobutylpyrimido[2,1-a]isoindol-4(6H)-one. LC-MS (M+H): 241.1.
76644-74-1 1H-Isoindol-3-amine hydrochloride 2795203, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; TaiGen Biotechnology Co., Ltd.; US2008/292626; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles