A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer’s disease was written by Lim, Hye Rim;Kim, Seo Yun;Jeon, Eun Hee;Kim, Yun Lan;Shin, Yu Mi;Koo, Tae-Sung;Park, Sung Jean;Hong, Ki Bum;Choi, Sungwook. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Safety of 2,3,3-Trimethyl-3H-indol-5-amine This article mentions the following:
The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer’s disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biol. matrix. In the experiment, the researchers used many compounds, for example, 2,3,3-Trimethyl-3H-indol-5-amine (cas: 773-63-7Safety of 2,3,3-Trimethyl-3H-indol-5-amine).
2,3,3-Trimethyl-3H-indol-5-amine (cas: 773-63-7) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Safety of 2,3,3-Trimethyl-3H-indol-5-amine
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles