Parrish, Jay P. published the artcileEstablishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065, SDS of cas: 796870-32-1, the publication is Bioorganic & Medicinal Chemistry (2003), 11(17), 3815-3838, database is CAplus and MEDLINE.
An extensive series of CBI analogs of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ≥1000-fold providing simplified analogs containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065.
Bioorganic & Medicinal Chemistry published new progress about 796870-32-1. 796870-32-1 belongs to indole-building-block, auxiliary class Indols, name is 7-Cyano-1H-indole-2-carboxylic acid, and the molecular formula is C10H6N2O2, SDS of cas: 796870-32-1.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles