Category: 81779-27-3

81779-27-3, 4-Hydroxy-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,81779-27-3

1: 0.40 g (1 mmol) of compound 0.66 g (1.1 mmol) of compound 2 was dissolved in 20 mL of methanol, and two drops of piperidine were added dropwise.As a catalyst, a reflux reaction was carried out under a nitrogen atmosphere, and the reaction was completed overnight, and the reaction was completed. Pass the crude product through column chromatographyThe developing agent of CH2Cl2/CH3OH=70:1 was separated and purified to obtain compound 3, and subjected to nuclear magnetic resonance spectroscopy.Structure (see Figure 1).

The synthetic route of 81779-27-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; University of Jinan; Lin Weiying; Wang Weishan; Liu Yong; Niu Jie; (10 pag.)CN108640902; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81779-27-3,4-Hydroxy-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.

81779-27-3, (b) Step 2 A solution of tert-butyl 4-[(6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate (0.056 g, 0.016 mmol) in methanol (2.0 mL) was added with 4-hydroxy-1H-indole-3-carboxaldehyde (0.026 g, 0.016 mmol). Then, the mixture was added with 5 drops of piperidine, and then the mixture was stirred at 60C for 2 hours. The solvent was evaporated under reduced pressure, and then the residue was subjected to silica gel column chromatography (aminopropyl silica was used, eluted with chloroform/methanol (90:10)) to obtain tert-butyl (Z)-4-({6-hydroxy-2-[(4-hydroxy-1H-indol-3-yl)methylene]-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.050 g, 64%). 1H NMR (300 MHz, DMSO-d6) delta 1.38 (s, 9H), 2.53 (m, 4H), 3.38 (m, 4H), 3.88 (s, 2H), 6.55 (d, J = 7.3 Hz, 1H), 6.72 (d, J = 8.1 Hz, 1H), 6.91-7.04 (m, 2H), 7.52 (d, J = 8.1 Hz, 1H), 7.69 (s, 1H), 8.06 (d, J = 2.9 Hz, 1H), 11.87 (s, 1H).

As the paragraph descriping shows that 81779-27-3 is playing an increasingly important role.

Reference：
Patent; The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi; EP2565192; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81779-27-3,4-Hydroxy-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.,81779-27-3

EXAMPLE 2 OF REFERENCE 3-Formyl-4-hydroxyindole-1-carboxylic Acid tert-butyl Ester (2-1) (R7=R11=H) A mixture of the 3-formyl-4-hydroxyindole (1-1) 323 mg, di-tert-butyldicarbonate 458 mg, dimethylaminopyridine 12.5 mg and acetonitrile 25 ml was stirred under cooling in ice for 3 h.The solvent was removed under reduced pressure and the residue obtained was recrystallized from acetone-isopropyl ether to give the titled compound as pale yellow crystals, m.p. 159-161 C.(dec.), 389 mg.Yield 74%. 1H-NMR(CDCl3): 1.71 (9H, s), 6.84 (1H, dd, J=8.1, 0.9 Hz), 7.31 (1H, t, J=8.1 Hz), 7.61 (1H, dd, J=8.1, 0.9 Hz), 8.25 (1H, s), 9.76 (1H, d, J=0.6 Hz), 10.13 (1H, s).

81779-27-3 4-Hydroxy-1H-indole-3-carbaldehyde 9815282, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Fukui, Yoshikazu; Adachi, Makoto; Sasatani, Takashi; US2003/236295; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles