Category: 81868-12-4

Some tips on 81868-12-4

81868-12-4 2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride 13241175, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81868-12-4,2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride,as a common compound, the synthetic route is as follows.

81868-12-4, A stirred suspension of 5-bromotryptamine hydrochloride (17.0 g, 61.7 mmol) in 250 mL of 0.1 N aqueous sulfuric acid was treated with isovaleraldehyde (10.0 mL, 92.6 mmol). The suspension was heated at 80 C. for 3 hr. The resulting solution was allowed to cool to ambient temperature then further cooled to 0 C. in an ice-water bath. The precipitated product was filtered, washed with MTBE (300 mL), dried overnight under high vacuum to give 6-bromo-1-isobutyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride 19.3 g (92%) as a white solid. 1H NMR (600 MHz, DMSO-d6) delta 11.41 (s, 1H), 9.92 (br. s., 1H), 9.46 (br. s., 1H), 7.66 (d, J=1.88 Hz, 1H), 7.33 (d, J=8.56 Hz, 1H), 7.21 (dd, J=1.88, 8.56 Hz, 1H), 4.66 (br. s., 1H), 3.54 (d, J=12.14 Hz, 1H), 3.27 (br. s., 1H), 2.86-3.01 (m, 2H), 2.01-2.09 (m, 1H), 1.91-1.99 (m, 1H), 1.83 (ddd, J=4.09, 10.23, 14.28 Hz, 1H), 1.03 (d, J=6.31 Hz, 3H), 0.97 (d, J=6.59 Hz, 3H).

81868-12-4 2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride 13241175, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; ALCON RESEARCH, LTD.; Ellis, David Archer; Mohapatra, Suchismita; Namil, Abdelmoula; Chen, Hwang-Hsing; Severns, Byron; Belanger, David B.; US2013/116219; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 81868-12-4

The synthetic route of 81868-12-4 has been constantly updated, and we look forward to future research findings.

81868-12-4, 2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,81868-12-4

A solution of 4-((3-fluorophenyl)(methyl)amino)benzoic acid (0.250 g, 1.09 mmol), 2-(5-bromo-1H-indol-3-yl)ethanamine hydrochloride (0.300 g; 1.09 mmol), HATU (0.414 g; 1.09 mmol) and N,N-diisopropylethylamine (0.469 mL; 2.72 mmol) in DMF (7 mL), was stirred at room temperature for 72 hours. The reaction mixture was then partitioned between ethyl acetate and sodium hydrogen sulfate and the organic layer was successively washed with a saturated aqueous solution of sodium carbonate and brine. The organic layer was dried, concentrated under reduced pressure and the crude material was purified by flash chromatography on silica gel (eluent 1 to 20% ethyl acetate in dichloromethane) to afford 0.395 g (81%) of the title compound as a white solid. [0652] ESI/APCI(+): 451, 453 (M+H); 473,475 (M+Na); ESI/APCI(-): 450, 451 (M-H).

The synthetic route of 81868-12-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Veronica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick; US2013/274260; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles