Category: 830-96-6

Duong, Thi Thuy et al. published their research in Chemosphere in 2021 | CAS: 830-96-6

3-Indolepropionic acid (cas: 830-96-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 830-96-6

Auxin production of the filamentous cyanobacterial Planktothricoides strain isolated from a polluted river in Vietnam was written by Duong, Thi Thuy;Nguyen, Thi Thu Lien;Dinh, Thi Hai Van;Hoang, Thi Quynh;Vu, Thi Nguyet;Doan, Thi Oanh;Dang, Thi Mai Anh;Le, Thi Phuong Quynh;Tran, Dang Thuan;Le, Van Nhan;Nguyen, Quang Trung;Le, Phuong Thu;Nguyen, Trung Kien;Pham, Thi Dau;Bui, Ha Manh. And the article was included in Chemosphere in 2021.Product Details of 830-96-6 This article mentions the following:

Cyanobacteria are photosynthetic microorganisms with widespread diversity and extensive global distribution. They produce a wide variety of bioactive substances (e.g., lipopeptides, fatty acids, toxins, carotenoids, vitamins and plant growth regulators) that are released into culture media. In this study, the capability of a cyanobacterial strain of Planktothricoides raciborskii to produce intra- and extracellular auxins was investigated. The filamentous cyanobacterial P. raciborskii strain was isolated from a river in Vietnam, and it was cultivated in the laboratory under the optimum conditions of the BG11 culture medium and a pH of 7.0. The auxins were identified and quantified by the Salkowski colorimetric method and high-performance liquid chromatog. coupled with mass spectrometry (HPLC-MS). Colorimetric anal. revealed that P. raciborskii produces extracellular indole-3-acetic acid (IAA) in the absence and presence of L-tryptophan. The maximum extracellular IAA concentration of the culture reached 118 卤 2渭g mL-1, which was supplemented with 900渭g mL-1 of L-tryptophan. HPLC-MS anal. revealed that the isolated cyanobacteria accumulate other plant-growth-promoting hormones besides IAA, such as indole-3-carboxylic acid (ICA), indole-3 butyric acid (IBA) and indole propionic acid (IPA). This is the first report on the production of auxins in an isolated strain of cyanobacteria Planktothricoides from a polluted river. The capability of producing auxins makes the P. raciborskii strain an appropriate candidate for the formulation of a biofertilizer. In the experiment, the researchers used many compounds, for example, 3-Indolepropionic acid (cas: 830-96-6Product Details of 830-96-6).

3-Indolepropionic acid (cas: 830-96-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 830-96-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

830-96-6, 3-Indolepropionic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. Preparation of 3-(lH-indol-3-yl)propan-l-ol: To a solution of 3-(lH-indol-3- yl)propanoic acid (1.6g, 8.5 mmol) in THF (15 mL) was added BH3 in THF (1M, 17 mL, 17 mmol) dropwise at 0 C. The reaction mixture was stirred for 20 min at 0 C then warmed to 20 C and stirred for 2h. The reaction was quenched by slow addition of MeOH (20 mL). The reaction mixture was stirred for additional 30 min at 20 C. The reaction mixture was concentrated and purified by flash chromatography (Combi-flash Rf, hex/EtOAc 0-40% gradient) to give the title compound (1.34 g, 7.65 mmol) as a light yellow oil. MS (ES) 176.2 (M+H)., 830-96-6

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VANDERBILT UNIVERSITY; LEE, Taekyu; KIM, Kwangho; CHRISTOV, Plamen P.; BELMAR, Johannes; BURKE, Jason P.; OLEJNICZAK, Edward T.; FESIK, Stephen W.; WO2015/31608; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 830-96-6

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

830-96-6, 3-Indolepropionic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. Preparation of 3-(lH-indol-3-yl)propan-l-ol: To a solution of 3-(lH-indol-3- yl)propanoic acid (1.6g, 8.5 mmol) in THF (15 mL) was added BH3 in THF (1M, 17 mL, 17 mmol) dropwise at 0 C. The reaction mixture was stirred for 20 min at 0 C then warmed to 20 C and stirred for 2h. The reaction was quenched by slow addition of MeOH (20 mL). The reaction mixture was stirred for additional 30 min at 20 C. The reaction mixture was concentrated and purified by flash chromatography (Combi-flash Rf, hex/EtOAc 0-40% gradient) to give the title compound (1.34 g, 7.65 mmol) as a light yellow oil. MS (ES) 176.2 (M+H)., 830-96-6

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VANDERBILT UNIVERSITY; LEE, Taekyu; KIM, Kwangho; CHRISTOV, Plamen P.; BELMAR, Johannes; BURKE, Jason P.; OLEJNICZAK, Edward T.; FESIK, Stephen W.; WO2015/31608; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Some tips on 830-96-6

830-96-6 3-Indolepropionic acid 3744, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.830-96-6,3-Indolepropionic acid,as a common compound, the synthetic route is as follows.

To a solution of 3-(lH-indol-3-yl)propanoic acid (1.5 g, 7.9 mmol) in THF (20 mL) was added 1M BH3 in THF (9 mL, 9 mmol) at 0 C. The reaction mixture was stirred for 1 h at 0 C and quenched by addition of MeOH then concentrated in vacuo. The residue was purified by flash chromatography (Combi-flash Rf Hexane/EtOAc gradient 0-25%) to give the title compound as a white solid in 1.2 g (7.1 mmol). MS (ES) 176.1 (M+H)., 830-96-6

830-96-6 3-Indolepropionic acid 3744, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; VANDERBILT UNIVERSITY; LEE, Taekyu; BIAN, Zhiguo; BELMAR, Johannes; CHRISTOV, Plamen P.; PELZ, Nicholas F.; SHAW, Subrata; KIM, Kwangho; TARR, James C.; OLEJNICZAK, Edward T.; ZHAO, Bin; FESIK, Stephen W.; WO2015/148854; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analyzing the synthesis route of 830-96-6

830-96-6, The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.830-96-6,3-Indolepropionic acid,as a common compound, the synthetic route is as follows.

To a 10 ml reaction tube by sequentially adding a substrate (0.2 mmol, 37.8 mg), trimethyl twelve alkyl iodide (0.02 mmol, 7.2 mg), 2 ml of water, and finally adding hydrogen peroxide (0.12 mmol, 120 mul). The reaction mixture at 60 C under stirring 48 h after stopping the reaction, to the reaction system by adding ethyl acetate (5 ml * 4), the combined organic phase and drying with anhydrous sodium sulfate, filtered vacuum concentrated to obtain the crude product. The resulting crude product is purified by column chromatography separation, to obtain white solid product, separating the yield is 67%

830-96-6, The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Huazhong University of Science and Technology; Zhong Fangrui; Wang Dangui; (18 pag.)CN109776381; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 830-96-6

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

830-96-6, 3-Indolepropionic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: H2SO4 (98%) (0.5mL) was added to a stirred solution of raw material1 in CH3OH (10mL) at room temperature and the mixture was then stirred for 2-3 h at 80 C. TLC was used to monitor the reaction progress until it was complete. A large amount of ice water was then added to the mixture. A saturated solution of sodium carbonate was used to neutralise the mixture until white solid appeared. After filtering the mixed solution, compounds 2a-h (yield 91-99) were obtained., 830-96-6

The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ye, Ying; Suo, Yourui; Yang, Fang; Yang, Yongjing; Han, Lijuan; Journal of Chemical Research; vol. 39; 5; (2015); p. 296 – 299;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analyzing the synthesis route of 830-96-6

830-96-6, The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.830-96-6,3-Indolepropionic acid,as a common compound, the synthetic route is as follows.

3-indole propionic acid (3.78 g, 20 mmol) was dissolved in methanol (50 ml) in argon. Thionyl chloride (4.7 g, 2.9 ml, 40 mmol) was added very slowly to this solution in drops. During this, the temperature rose to 35 C. The mixture was then heated to reflux for 7 h and stirred overnight at room temperature. Complete conversion was evident in the DC. The LC/MS shows slight traces of a by-product. The batch was concentrated to low volume under the exhaust hood and co-distilled with methanol. The residue was a brown oil, which was thus used for the next reaction step.

830-96-6, The synthetic route of 830-96-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GRUNENTHAL GMBH; US2009/247573; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles