With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83150-76-9,Octreotide,as a common compound, the synthetic route is as follows.
Embodiment 1 : Synthesis of D-Phe-c[Cys-Phe-D-Trp-Lys(Boc)-Thr-Cys]-Thr(ol); Into a round bottom flask, 100mg of octreotide was put and dissolved by adding 5mL of N,N-dimethylformamide. After the octreotide completely dissolved, 20muL of (Boc)2O was added to the flask. The mixture reacted at room temperature for 24 hours and then the solvent was extracted by using a vacuum system to obtain a crude product, D-Phe-c[Cys-Phe-D-Trp-Lys(Boc)-Thr-Cys]-Thr(ol). Finally, the crude product was purified by a high performance liquid chromatography through a column of Hibar 250-10 Lichrosorb RP-18 (7mum) produced by Merck & Co., Inc., with 0.1% of trifluoroacetic acid/H2O as an eluent and 40 minutes (80% ~ 10%) as analytic time. The resultant retention time was 29.4 minutes. The solution from the major peak was collected and then subjected to freeze dry to obtain solid white powder (72mg, yield: 70%) which was analyzed mass spectrometry as [M+H]+=1119Da.
The synthetic route of 83150-76-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute of Nuclear Energy Research, Atomic Energy Council; EP1935433; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles