Properties and Exciting Facts About 5-Bromo-2-phenyl-1H-indole

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 83515-06-4, molcular formula is C14H10BrN, introducing its new discovery. HPLC of Formula: C14H10BrN

The present invention relates to a novel compound and an organic electroluminescence device including the same, and the compound according to the present invention may be used in an organic material layer, preferably a light-emitting layer of an organic electroluminescence device, thereby enhancing the light-emitting efficiency, driving voltage, lifespan, and the like of the organic electroluminescence device.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Reference of 83515-06-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.83515-06-4, Name is 5-Bromo-2-phenyl-1H-indole, molecular formula is C14H10BrN. In a article,once mentioned of 83515-06-4

A palladium-catalyzed tandem addition/cyclization of 2-(2-aminoaryl)acetonitriles with arylboronic acids has been developed for the first time, achieving a new strategy for direct construction of indole skeletons. This system shows good functional group tolerance and remarkable chemoselectivity. In particular, the halogen (e.g., bromo and iodo) substituents are amenable to further synthetic elaborations thereby broadening the diversity of the products. Preliminary mechanistic experiments indicate that this transformation involves sequential nucleophilic addition followed by an intramolecular cyclization.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Extracurricular laboratory:new discovery of 5-Bromo-2-phenyl-1H-indole

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Rhodium-Catalyzed Selective Oxidative (Spiro)annulation of 2-Arylindoles by Using Benzoquinone as a C2 or C1 Synthon

Rhodium-catalyzed substrate-tunable oxidative annulation and spiroannulation reactions of 2-arylindoles with benzoquinone leading to 9H-dibenzo[a,c]carbazol-3-ols and new spirocyclic products are reported. Intriguingly, with 2-aryl-substituted indoles, benzoquinone could act as a C2 synthon to afford dibenzo[a,c]carbazoles. On the contrary, when 2-aryl-3-substituted indoles were used, benzoquinone switched to act as a C1 synthon to furnish spirocyclic compounds. In addition, further transformations of the obtained products demonstrate the synthetic utility of the present protocol.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Can You Really Do Chemisty Experiments About 5-Bromo-2-phenyl-1H-indole

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A method for synthesis of indole derivatives (by machine translation)

The invention relates to a kind of the formula shown in (III) method for synthesis of indole derivatives, the method comprises in a solvent under an inert gas atmosphere and, in catalyst, a nitrogen-containing ligand, in the presence of acid promoter and KF, represented by the formula (I) compound with the following formula (II) compound generating reaction, after-treatment after reaction, so as to obtain the compound of said formula (III), wherein R 1 is selected from H or halogen; R 2 selected from H, C 1 ? C 6 alkyl, C 1 ? C 6 alkoxy or halogen. The stated method, through suitable substrate, catalyst, a nitrogen-containing ligand, acidic promoter and KF and the overall solvent selection with the cooperative, thereby expanding the range of the substrate, and the yield is indole derivatives can be good, thus the in the field of organic chemical synthesis has good application prospect and research value, for the synthesis of such compounds to provide a completely new method. (by machine translation)

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Development of an Efficient Procedure for Indole Ring Synthesis from 2-Ethynylaniline Derivatives Catalyzed by Cu(II) Salts and Its Application to Natural Product Synthesis

The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated. Cu(OAc)2 has been proved to be the best catalyst for the synthesis of various 1-p-tolylsulfonyl or 1-methylsulfonylindoles, which have both electron-withdrawing and electron-donating groups on the aromatic ring and C2 position of indoles. For the primary aniline derivatives, Cu(OCOCF 3)2 showed good activities, while Cu(OAc)2 was a good catalyst for the cyclization of secondary anilines. This methodology could be applied to the sequential cyclization reaction for the compounds which have the electrophilic part in the same molecule. By prior treatment with KH, the sequential cyclization was realized to provide the tricyclic ring systems, but it was limited to five- and six-membered rings for the second cyclization. Finally, formal and total synthesis of hippadine with the Cu(II)-promoted indole synthesis as the key step was accomplished.

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Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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An asymmetric normal-electron-demand aza-Diels-Alder reaction via trienamine catalysis

An asymmetric normal-electron-demand aza-Diels-Alder cycloaddition of 2-aryl-3H-indol-3-ones and 2,4-dienals was explored via trienamine catalysis of a chiral secondary amine. Multifunctional tricyclic polyhydropyrido[1,2-a] indoles were efficiently constructed in good stereoselectivity (up to 92% ee, >19:1 dr).

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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83515-06-4 5-Bromo-2-phenyl-1H-indole 838923, aindole-building-block compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83515-06-4,5-Bromo-2-phenyl-1H-indole,as a common compound, the synthetic route is as follows.

83515-06-4, A stream of nitrogen under 2-nitrophenylboronic acid (11.04 g, 66.14 mmol) and the preparation example 18 of In the obtained 5-bromo-2-phenyl-1H-indole (15 g, 55.12 mmol), NaOH (6.61 g, a mixture of 165.36 mmol) and THF / H2O (200 ml / 100 ml), and then insert the Pd (PPh3) 4 (3.18 g, 5 mol) in 40 , was stirred for 12 hours at 80 .After completion of the reaction, extracted with methylene chloride, and then filtered into a MgSO4. After removal of the solvent in the resulting organic layerColumn chromatography (Hexane: EA = 5: 1 (v / v)) to give 5- (2-nitrophenyl) -2-phenyl-1H-indole to obtain a (10.74 g, yield 62%). 1H-NMR: delta 6.88 (dd, 1H), 7.21 (d, 1H), 7.32 (m, 1H), 7.34 (d, 1H), 7.46 (m, 3H), [0382] 7.64 (m, 2H), 7.77(d, 2H), 8.02 (d, 2H), 11.73 (s, 1H).

83515-06-4 5-Bromo-2-phenyl-1H-indole 838923, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Doosan Co. Ltd.; Lee, Young Hwan; Kim, Tae Hyoung; Son, Hyo? Seok; Bae, Hyeong Chan; Park, Ho Cheol; Lee, Chang Jun; Shin, Jin Young; Baek, Young Mi; (97 pag.)KR101571589; (2015); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles