With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83683-82-3,4-Nitro-7-azaindole,as a common compound, the synthetic route is as follows.
83683-82-3, To a suspension of Int-20 (16.2 g, 100 mmol) in TFA (150 mL) was added Et3SiH (30.2 g, 260 mmol). The resulting mixture was stirred at 50 C for 1 hour. The solvent was removed under reduced pressure and the residue was dissolved in DCM (100 mL). Sat. NaHC03 (aq) was added cautiously to adjust to neutral pH. The organic phase was collected and concentrated to dryness. The residue was trituated with petroleum ether (25 mL) to afford Int-21 (16 g, yield: 97%).1H NMR (400 MHz, CDC13) delta 7.47 (d, J= 8.3 Hz, 1H), 7.13 (t, J= 8.0 Hz, 1H), 6.82 (d, J = 7.7 Hz, 1H), 4.05 (s, 1H), 3.68 (t, J= 8.5 Hz, 2H), 3.54 (t, J= 8.4 Hz, 2H).
The synthetic route of 83683-82-3 has been constantly updated, and we look forward to future research findings.
Reference£º
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