New one-pot synthesis of 3-alkyl- and 3-(蠅-hydroxyalkyl)oxindoles from isatins was written by Volk, Balazs;Simig, Gyula. And the article was included in European Journal of Organic Chemistry in 2003.Category: indole-building-block This article mentions the following:
A new and efficient one-pot procedure has been developed for the synthesis of 3-alkyl- and 3-(蠅-hydroxyalkyl)oxindoles from isatins by treatment with alcs. and diols in the presence of Raney nickel, under hydrogen atm. In the experiment, the researchers used many compounds, for example, 7-Methoxyindoline-2,3-dione (cas: 84575-27-9Category: indole-building-block).
7-Methoxyindoline-2,3-dione (cas: 84575-27-9) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles