Category: 851211-74-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.851211-74-0,1H-Indole-6-carbohydrazide,as a common compound, the synthetic route is as follows.

851211-74-0, General procedure: Acetic acid (36%) (0.5 mL) was added to a mixture of compound 3 (1.5mmol) and benzene-1,4-dicarbaldehyde (0.5 mmol) in DMF (3 ml) atroom temperature. The solution was irradiated for 5-10 min at 450 W and compound 4 was formed. After the mixture was cooled to roomtemperature, water (30 mL) was added to the reaction. The solid which formed was filtered and recrystallised from DMF-C2H5OH-H2O, to give receptors 4a-h (yield 84-99).

As the paragraph descriping shows that 851211-74-0 is playing an increasingly important role.

Reference：
Article; Ye, Ying; Suo, Yourui; Yang, Fang; Yang, Yongjing; Han, Lijuan; Journal of Chemical Research; vol. 39; 5; (2015); p. 296 – 299;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

851211-74-0,851211-74-0, 1H-Indole-6-carbohydrazide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a 50 mL three-necked flask were added 1.5 mmol of intermediate 3a-3c, 3 ml of DMF, 0.5 ml of acetic acid (36%), 0.5mmol of isophthalaldehyde, reflux reaction at 450W microwave power for 5-10min (TLC monitoring reaction process) The reaction was stopped and cooled to room temperature. To the reaction system was added 30 mL of water to give a large amount of solid which was filtered to give the crude product which was recrystallized from DMF-ethanol-water to give the title compound 4a-4c

The synthetic route of 851211-74-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chinese Academy Of Sciences Northwest Plateau Biological Institute; Suo Yourui; Ye Ying; Han Lijuan; (8 pag.)CN104529863; (2017); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles