875781-44-5, 5-Bromo-3-iodo-4,7-diazaindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,875781-44-5
2-bromo-7-iodo-5-(phenylsulfonyl)-5H-pyrrolor3,2-blpyrazine (V-E-I); A mixture of (IV-E-I) (7.74 g, 23.9 mmol), PhSO2Cl (6.54 g , 4.73 mL , 37.04 mmol), Bu4NHSO4 (1.217 g , 3.584 mmol) and 50% aqueous NaOH (5 mL, 7.65 g, 95.6 mmol) in CH2Cl2 (100 mL) was stirred vigorously at RT for 3 h. A saturated solution of NaHCO3 (50 mL) was added and the mixture was extracted with CH2Cl2 (4 x 50 mL). The combined organic extracts were dried (MgSO4), concentrated, and the residue was triturated with MeOH (100 mL). The solid was filtered off and dried in vacuo to afford V-E-I (9.34 g, 85%) as yellow solid. 1H NMR (400 MHz, CDCl3) delta 7.49-7.60 (m, 2H), 7.62-7.73 (m, IH), 8.15 (d, J0.51, IH), 8.16-8.21 (m, 2H), 8.44 (d, J0.38, IH). MS (ES) M+ m/e = 464.
The synthetic route of 875781-44-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; EISAI R & D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh; WO2010/15803; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles