882679-96-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.882679-96-1,Methyl 4-bromo-1H-indole-6-carboxylate,as a common compound, the synthetic route is as follows.
Step a. To a solution of methyl 4-bromo-lH-indole-6-carboxylate (CAS Number 882679-96-1) (1.0 g, 3.95 mmol) in TFA (5 ml) was added triethylsilane (1.9 ml, 11.86 mmol) at rt. The reaction mixture was stirred at 60C for 45 min. The resulting reaction mixture was cooled to rt, poured into saturated NaHC03 solution (50 ml) extracted with EtOAc (3 x 30 ml). The combined organic layer was dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (10% EtOAc in hexane) yielding methyl 4-bromoindoline-6-carboxylate (0.75 g, 29.4 mmol). LCMS: Method C, 2.31 min, MS: ES+ 256.3, 258.3; NMR (400 MHz, DMSO-d6) delta ppm 7.20 (d, J= 1.2 Hz, 1H), 6.94 (d, J=1.6 Hz, 1H), 6.19 (s, 1H), 3.80 (s, 3H), 3.54 (t, J=8.8 Hz, 2H), 2.97 (t, J=8.8 Hz, 2H).
The synthetic route of 882679-96-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MISSION THERAPEUTICS LIMITED; KEMP, Mark; STOCKLEY, Martin; JONES, Alison; (138 pag.)WO2017/9650; (2017); A1;,
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