Category: 883526-76-9

On December 31, 2022, Tan, Jian-Ping; Li, Kehan; Shen, Boming; Zhuang, Cheng; Liu, Zanjiao; Xiao, Kai; Yu, Peiyuan; Yi, Bing; Ren, Xiaoyu; Wang, Tianli published an article.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde The title of the article was Asymmetric synthesis of N-bridged [3.3.1] ring systems by phosphonium salt/Lewis acid relay catalysis. And the article contained the following:

Here, a general and modular method for constructing these pseudo-natural N-bridged [3.3.1] ring systems via cascade process by bifunctional phosphonium salt/Lewis acid relay catalysis were reported. A wide variety of substrates bearing an assortment of functional groups (59 examples) were compatible with this protocol. Other features include a [3 + 2] cyclization/ring-opening/Friedel-Crafts cascade pathway, excellent reactivities and stereoselectivities, easily available starting materials, step economy and scalability. The obtained enantioenriched products showed potential of preliminary anticancer activities. Insights gained from our studies are expected to advance general efforts towards the catalytic synthesis of challenging even unprecedented chiral PNPs, offering new opportunities for bioactive small-mol. discovery. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to bridged indole alkaloid preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 19, 2017, Zhang, Kaifan; Xu, Xiaoying; Zheng, Jiuan; Yao, Hequan; Huang, Yue; Lin, Aijun published an article.HPLC of Formula: 883526-76-9 The title of the article was [3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones. And the article contained the following:

A novel [3 + 3] cycloaddition between in situ formed azaoxyallyl cations and 2-alkenylindoles has been developed. This concise method allows the efficient construction of a series of tetrahydro-β-carbolinones in good yields under mild conditions. Gram-scale experiments and further derivatization of tetrahydro-β-carbolinones highlighted the potential utility of our method. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9

The Article related to tetrahydrocarbolinone preparation cycloaddition alkenylindole in situ formed azaoxyallyl cation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 2, 2016, Yang, Wu-Lin; Li, Chun-Yan; Qin, Wen-Jing; Tang, Fei-Fei; Yu, Xingxin; Deng, Wei-Ping published an article.HPLC of Formula: 883526-76-9 The title of the article was Cu(I)-Catalyzed Chemoselective and Stereoselective [3 + 3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines. And the article contained the following:

A Cu(I)-catalyzed asym. [3+3] cycloaddition of azomethine ylides with 2-indolylnitroethylenes is described. Challenges confronted in this reaction include chemoselectivity between [3+2] cycloaddition and [3+3] cycloaddition, reactivity and stereoselectivity of intramol. Friedel-Crafts reaction, and enantioselective control for constructing tetrahydro-γ-carbolines bearing multiple stereocenters. In the presence of copper(I)/Ph-Phosferrox complex, an array of chiral tetrahydro-γ-carboline compounds was generally obtained in moderate to high yields (up to 92%) with moderate to high chemoselectivities (up to 94:6 cr) and a high level of stereoselectivity (up to >98:2 dr, >99% ee in most cases). The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9

The Article related to carboline tetrahydro preparation, copper catalyst asym cycloaddition azomethine ylide indolylnitroethylene, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shang, Hai; Tian, Yu; Luo, Jun; Li, Lingyu; Tang, Yefeng; Zou, Zhongmei published an article in 2016, the title of the article was Rhodium(II)-catalyzed intramolecular annulation of 1-sulfonyl-1,2,3-triazoles with indoles: facile synthesis of functionalized tetrahydro-β-carbolines.Electric Literature of 883526-76-9 And the article contains the following content:

A novel rhodium(II)-catalyzed intramol. annulation of 1-sulfonyl-1,2,3-triazoles with indoles was developed, which enabled the facile synthesis of various 4-functionalized tetrahydro-β-carbolines as well as relevant scaffolds from readily available starting materials. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Electric Literature of 883526-76-9

The Article related to indolyl sulfonyltriazole preparation rhodium catalyst intramol cyclization, tetrahydro carboline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

He, Yi; Wu, Danjun; Li, Zhenghua; Robeyns, Koen; Van Meervelt, Luc; Van der Eycken, Erik V. published an article in 2019, the title of the article was Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:

A gold-catalyzed post-Ugi chemo- and diastereoselective cascade dearomative spirocyclization/1,6-addition sequence was disclosed for the synthesis of diverse fused polyheterocyclic scaffolds such as I [R1 = H, Me, Ac, Bn; R2 = H, Me; R3 = n-Bu, t-Bu, cyclohexyl, Bn etc.; R4 = H, Me, n-Pr, n-Bu, Ph; R5 = H, Me] bearing indole, pyrrole, benzothiophene, furan or electron-rich arene moieties from easily available building blocks. The effectiveness and efficiency of this diversity-oriented approach had proved in the rapid construction of 28 fused polyheterocyclic scaffolds with a good building-block variability and structural complexity in two operational steps. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to fused polyheterocycle chemoselective diastereoselective preparation, adduct ugi tandem dearomative spirocyclization addition gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 31, 2019, Xu, Shi-Ming; Wei, Liang; Shen, Chong; Xiao, Lu; Tao, Hai-Yan; Wang, Chun-Jiang published an article.Application of 883526-76-9 The title of the article was Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction. And the article contained the following:

An expedient and stereodivergent assembly of tetrahydro-γ-carbolines I [R = Ph, 4-ClC6H4, 2-furanyl, etc.; R1 = H, Me, Bn, etc.; R2 = H, 4-Me, 5-Cl, etc.] with remarkably high levels of stereoselective control in an efficient cascade process from aldimine esters and indolyl allylic carbonates via a synergistic Cu/Ir catalyst system was reported. Control experiments-guided optimization of synergistic catalysts and mechanistic investigations reveal that a stereodivergent allylation reaction and a subsequent highly stereoselective iso-Pictet-Spengler cyclization were the key elements to success. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Application of 883526-76-9

The Article related to tetrahydro gamma carboline enantioselective preparation, aldemine ester indolyl allylic carbonate tandem allylation pictet spengler, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 17, 2021, Uredi, Dilipkumar; Burra, Amarender Goud; Watkins, E. Blake published an article.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde The title of the article was Rapid Access to 3-Substituted Pyridines and Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira Cross-Coupling/6π-Aza Cyclization Sequence. And the article contained the following:

Herein, a one-pot, three-component method for the preparation of 3-substituted pyridines such as I [R = H, Me, Ph, tert-butoxycarbonyl; Ar = Ph, 2-MeC6H4, 3-quinolyl, etc.; R1 = H, 6-Me, 8-Me, 5-MeO], II [R2 = R2 = H; R2R3 = HCCH=CHCH; X = S, O] and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization was reported. This arylation cross-coupling/annulation cascade provided easy access to substituted, fused pyridines I, II from readily available substrates in good yields (67-92%) with complete selectivity. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to pyridoindolyl methyl aryl preparation, aryl iodide indole carboxaldehyde propargylamine domino sonogashira coupling aza, cyclization catalyst palladium, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Chao; Van Meervelt, Luc; Peshkov, Vsevolod A.; Van der Eycken, Erik V. published an article in 2022, the title of the article was The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence.Computed Properties of 883526-76-9 And the article contains the following content:

A novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffolds in a highly efficient manner starting from readily accessible multifunctional Ugi adducts, e.g., I, was developed. The developed methodol. is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Computed Properties of 883526-76-9

The Article related to benzazepinoindole polycyclic compound preparation regioselective chemoselective, alkynyl amide tandem cyclization hydroarylation michael addition gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Computed Properties of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zheng, Rimei; Xu, Aimin; Huang, Jiawu; Zhang, Zhijing; Yin, Xinru; Zhang, Tianyuan; Hu, Wenhao; Qian, Yu published an article in , the title of the article was A Rh(II)-catalyzed highly stereoselective [3 + 2] annulation of vinyl diazoacetates with indole-2-carbaldehyde for the synthesis of indolyl dihydrofurans.Product Details of 883526-76-9 And the article contains the following content:

A highly stereoselective Rh2(Oct)4catalyzed [3 + 2] cycloaddition of vinyl diazoacetates 2,6-(Me)2C6H3OC(O)C(=N2)CH=CHAr (Ar = Ph, 2-naphthyl, 2-methylphenyl, etc.) with indolyl aldehydes I (R = Me, Bn; R1 = 5-Cl, 3-Me, 5-Me, etc.) has been developed. This protocol provides an efficient access to both cis and trans indolyl dihydrofurans (4R,5R/4R,5S)-II with high yields and diastereoselectivities under mild conditions without or with Lewis acid as additive, resp. Moreover, these generated functionalized dihydrofurans exhibit potent antiproliferation activity in three different cancer cell lines. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Product Details of 883526-76-9

The Article related to indolyl dihydrofuran preparation diastereoselective chemoselective, vinyl diazoacetate indole carbaldehyde cycloaddition rhodium catalyst, carbonyl ylide, indolyl dihydrofurans, vinyl metal carbene and other aspects.Product Details of 883526-76-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Qiu, Youai; Fu, Chunling; Zhang, Xue; Ma, Shengming published an article in 2014, the title of the article was Studies on [PtCl2]- or [AuCl]-Catalyzed Cyclization of 1-(Indol-2-yl)-2,3-Allenols: The Effects of Water/Steric Hindrance and 1,2-Migration Selectivity.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde And the article contains the following content:

The [PtCl2]- or [AuCl]-catalyzed reaction of 1-(indol-2-yl)-2,3-allenols occurred smoothly at room temperature to afford a series of poly-substituted carbazoles efficiently. Compared with the [PtCl2]-catalyzed process, the [AuCl]-catalyzed reaction represents a significant advance in terms of the scope and the selectivity. Selective 1,2-alkyl or aryl migration of the gold carbene intermediate was observed: compared with the Me group, the iso-Pr, cyclopropyl, cyclobutyl, and cyclohexyl groups migrate exclusively; the cyclopropyl group shifts selectively over the Et group; the 1,2-migration of a non-Me linear alkyl is faster than Me group; the Ph group migrates exclusively over Me or Et group. DFT calculations show that water makes the elimination of H2O facile requiring a much lower energy and validates the migratory preferences of different alkyl or Ph groups observed The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

The Article related to cyclization indolylallenols mechanism platinum gold chloride catalyst, dft cyclization indolylallenols platinum gold chloride catalyst, allenes, carbenes, density functional calculations, gold, platinum and other aspects.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles