On March 26, 2020, Watkins, Edmond Blake; Uredi, Dilipkumar; Motati, Damoder Reddy published a patent.Product Details of 883526-76-9 The title of the patent was Preparation of pyridines, β- and γ-carbolines, and other fused azaheteroaromatics under mild, metal-free conditions including pyridine monoterpenoid and pyridoindole alkaloids. And the patent contained the following:
The invention relates to novel methods of preparation of substituted pyridines, β-carbolines, γ-carbolines and other fused azaheteroaroms that include pyrrolopyridine, furopyridine, thienopyridine, benzofuropyridine, pyrrolodipyridine, benzothienopyridine, phenanthroline and benzisoquinoline under metal-free conditions, starting from propargylic amines and α,β-unsaturated carbonyl compounds involving imine formation followed by concomitant cyclization through an allenyl intermediate in the presence of a mild base, e.g., NaHCO3, in DMF. In particular, the invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products such as pyridine monoterpenoid and pyridoindole alkaloids. The formal synthesis of oxopropalines D and G on a gram-scale 4,9-dimethyl-9H-Pyrido[3,4-b]indole, in a one-pot reaction from com. available materials (previous shortest reported route was 5 steps) and one-step synthesis of the monoterpene alkaloid, (-)-actinidine as long as the preparation in two steps of an analog of oxopropaline are given. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Product Details of 883526-76-9
The Article related to pyridine preparation heteroaromatic aldehyde propargylic amine metal free heterocyclization, heteroaromatic aldehyde propargylic amine one step condensation heterocyclization aromatization, pyrrolopyridine furopyridine thienopyridine benzofuropyridine pyrrolodipyridine benzothienopyridine phenanthroline benzisoquinoline preparation and other aspects.Product Details of 883526-76-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles