Zou, Bin’s team published research in Tetrahedron in 2014 | CAS: 885518-25-2

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C8H7FN2

Zou, Bin; Chen, Chun; Leong, Seh Yong; Ding, Mei; Smith, Paul W. published an article on January 21 ,2014. The article was titled 《An efficient synthesis of 4,6-dihydrospiro[azepino[4,3,2-cd]indole-3,3′-indoline]-2′,5(1H)-diones via multi-component reaction》, and you may find the article in Tetrahedron.Electric Literature of C8H7FN2 The information in the text is summarized as follows:

A facile and efficient one-pot three-component synthesis of spiroazepinoindolones has been developed. Using DMF as solvent without any addnl. acid or metal catalysts, the three-component reaction of readily available isatins, indolamines, and Meldrum’s acid affords a new class of spiroheterocycles in moderate yield. In the experimental materials used by the author, we found 6-Fluoro-1H-indol-4-amine(cas: 885518-25-2Electric Literature of C8H7FN2)

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C8H7FN2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liao, Hui’s team published research in Organic & Biomolecular Chemistry in 2020 | CAS: 885518-25-2

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 885518-25-2

《Water-DMSO-promoted one-pot synthesis of two new series of dihydropyrrolo[2,3-h]quinolines》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Liao, Hui; Zhu, Qiuhua. HPLC of Formula: 885518-25-2 The article mentions the following:

Here, two new series of dihydropyrrolo[2,3-h]quinolines I (R1 = Me, Et, t-Bu; R2 = H, F, Cl; R3 = H, Me; R4 = C6H5, 4-FC6H4, 4-MeC6H4, etc.) with more substituents on the quinoline ring were efficiently synthesized via catalyst-free three-component reaction (3CR) of but-2-ynedioates, 4-aminoindoles and aldehydes or isatins in a DMSO-water (volume ratio: 2.5 : 1) mixture in moderate to good yields. A possible mechanism was proposed based on the crucial and promoted effects of water and DMSO in the 3CR, resp. In addition, it was found that dihydropyrrolo[2,3-h]quinolines could be quant. oxidized into new pyrrolo[2,3-h]quinolines at room temperature using Cu(NO3)2 as an oxidant. This work affords efficient synthesis methods for constructing a library of new pyrrolo[2,3-h]quinolines and is expected to promote the research on the bioactivities of pyrrolo[2,3-h]quinolines. In the part of experimental materials, we found many familiar compounds, such as 6-Fluoro-1H-indol-4-amine(cas: 885518-25-2HPLC of Formula: 885518-25-2)

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 885518-25-2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Shaomin’s team published research in Organic & Biomolecular Chemistry in 2019 | CAS: 885518-25-2

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C8H7FN2

The author of 《4-Aminoindoles as 1,4-bisnucleophiles for diversity-oriented synthesis of tricyclic indoles bearing 3,4-fused seven-membered rings》 were Chen, Shaomin; Ravichandiran, Palanisamy; El-Harairy, Ahmed; Queneau, Yves; Li, Minghao; Gu, Yanlong. And the article was published in Organic & Biomolecular Chemistry in 2019. Formula: C8H7FN2 The author mentioned the following in the article:

A straightforward access to tricyclic indoles bearing 3,4-fused seven-membered rings I [R = H, Me; R1 = H, F, Br, COOMe; R2 = H, C(O)Me, COOEt, COOMe; R3 = H, COOMe, COOEt, Ph; R2R3 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)2OCH2-; R4 = cyclopropyl, 4-methylphenyl, 2-naphthyl, 2-furyl, etc.] and II [R5 = CH2, C(Me)2] and 4-(p-tolyl)-1,3,4,6-tetrahydro-2H-azepino[4,3,2-cd]indol-2-one has been established by using 4-aminoindoles as 1,4-bisnucleophiles III (R6 = H, F, Br, COOMe) in three-component reactions. 1H-Azepino[4,3,2-cd]indoles, 4,6-dihydro-1H-azepino[4,3,2-cd]indoles and 1,3,4,6-tetrahydro-5H-azepino[4,3,2-cd]indol-5-ones could thus be synthesized in one pot in moderate to good yields. Beyond opening access to 3,4-fused tricyclic indoles, the use of easily accessible 4-aminoindoles as C,N-1,4-bisnucleophiles also provides a new platform to be used in a diversity-oriented synthesis strategy, fully displaying its benefits of maximizing mol. complexity and reaction diversity. In the experiment, the researchers used many compounds, for example, 6-Fluoro-1H-indol-4-amine(cas: 885518-25-2Formula: C8H7FN2)

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C8H7FN2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Some tips on 885518-25-2

The synthetic route of 885518-25-2 has been constantly updated, and we look forward to future research findings.

885518-25-2, 6-Fluoro-1H-indol-4-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,885518-25-2

To a solution of intermediate 12 (233.00 mg, 0.61 mmol), intermediate 34c (100.00 mg,0.67 mmol), Pd(OAc)2 (137.00 mg, 0.061 mmol) and Cs2CO3 (592.00 mg, 1.82 mmol) in1,4-dioxane (5 mL) was added BNAP (38.00 mg, 0.06 1 mmol) and the reaction mixturewas heated for 3 h at 95 C. The reaction mixture was then diluted with ethyl acetate and washed with water and brine. The organic layer was dried with sodium sulfate and concentrated in vacuo to give 397 mg of intermediate 35c (quant. yield, 76% purity based on LC/MS, dark black foam) which was used in the next step without any further purification.

The synthetic route of 885518-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (419 pag.)WO2018/2219; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 885518-25-2

As the paragraph descriping shows that 885518-25-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885518-25-2,6-Fluoro-1H-indol-4-amine,as a common compound, the synthetic route is as follows.,885518-25-2

General procedure: The solution of isatin (380 mumol), 1H-indole-4-amine (380 mumol, 1.0 equiv), and Meldrum’s acid (380 mumol, 1.0 equiv) in DMF (4.0 ml) was heated to 120 C for 2 h. The reaction mixture was cooled down to room temperature and concentrated to remove the solvents. The crude residue was subjected to reverse phase preparative HPLC to provide pure products.

As the paragraph descriping shows that 885518-25-2 is playing an increasingly important role.

Reference:
Article; Zou, Bin; Chen, Chun; Leong, Seh Yong; Ding, Mei; Smith, Paul W.; Tetrahedron; vol. 70; 3; (2014); p. 578 – 582;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

New learning discoveries about 885518-25-2

885518-25-2 6-Fluoro-1H-indol-4-amine 24728022, aindole-building-block compound, is more and more widely used in various fields.

885518-25-2, 6-Fluoro-1H-indol-4-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,885518-25-2

Step D: l-(4-chlorobenzyl)-6-fluoro-lH-indol-4-amineA mixture of 6-fluoro-lH-indol-4-amine (5 g, 0.033 mol), 4-chlorobenzyl chloride (5.55 g, 0.035 mol) and sodium hydroxide (1.32 g, 0.033 mol) was heated at 60 C for 3 h. The solvent was evaporated and the residue was dissolved in EA (150 mL) and water (70 mL). The aqueous layer was extracted with EA and washed with brine (100 mL), dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel flash chromatography (PE: EA = 8 1) to afford the title compound. LC/MS m/z = 275.1 [M+H]+.

885518-25-2 6-Fluoro-1H-indol-4-amine 24728022, aindole-building-block compound, is more and more widely used in various fields.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CRESPO, Alejandro; LAN, Ping; MAL, Rudrajit; OGAWA, Anthony; SHEN, Hong; SINCLAIR, Peter J.; SUN, Zhongxiang; BUNTE, Ellen K. Vande; WU, Zhicai; LIU, Kun; DEVITA, Robert J.; SHEN, Dong-Ming; SHU, Min; TAN, John Qiang; QI, Changhe; WANG, Yuguang; BERESIS, Richard; WO2012/97744; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles