With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89245-41-0,4-Bromoindole-3-acetic Acid,as a common compound, the synthetic route is as follows.
89245-41-0, Example 7 methyl (4-bromo-1H-indol-3-yl)acetic acid To methanol (10 mL), thionyl chloride (0.76 mL) was added dropwise at -15 to -10C, followed by stirring for 30 minutes. To the mixture, (4-bromo-1H-indol-3-yl)acetic acid (, 1.32 g) was added, followed by stirring at room temperature for 2 hours. To the reaction mixture, an aqueous saturated sodium hydrogen carbonate solution was added, followed by extraction with ethyl acetate. The organic layer was washed in turn with water and saturated saline, dried and then concentrated. The residue was washed with diisopropyl ether/n-hexane (1:2) to obtain the titled compound having the following physical properties (1.26 g). TLC: Rf 0.41 (n-hexane: ethyl acetate = 1:1); 1H-NMR(CDCl3): delta 3.74 (s, 3H), 4.06 (s, 2H), 6.98 (t, 1H), 7.10 (d, 1H), 7.23-7.27 (m, 2H), 8.25 (brs, 1H).
As the paragraph descriping shows that 89245-41-0 is playing an increasingly important role.
Reference：
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1852420; (2007); A1;,
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