Category: 913287-12-4

Awesome Chemistry Experiments For 913287-12-4

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 913287-12-4 is helpful to your research. Reference of 913287-12-4

Reference of 913287-12-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.913287-12-4, Name is Ethyl 5-fluoro-7-nitro-1H-indole-2-carboxylate, molecular formula is C11H9FN2O4. In a Patent，once mentioned of 913287-12-4

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 913287-12-4 is helpful to your research. Reference of 913287-12-4

Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.913287-12-4,Ethyl 5-fluoro-7-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

1.85 g (6.15 mmol) of ethyl 5-fluoro-7-nitro-1H-indole-2-carboxylate were initially charged in 20 ml of ethanol, admixed with 517 mg (9.22 mmol) of potassium hydroxide and stirred under reflux overnight. Subsequently, ethyl acetate was added, the mixture was extracted with 1 M sodium hydroxide solution and the pH of the aqueous phase was adjusted to pH 2 with hydrochloric acid.The mixture was extracted repeatedly with ethyl acetate, the organic phase was washed with saturated sodium chloride solution and dried over magnesium sulfate, filtered and concentrated. This gave 1.35 g (98% of theory) of the title compound.1H-NMR (400 MHz, DMSO-d6): delta=7.37 (d, 1H), 8.12 (dd, 1H), 8.16 (dd, 1H), 11.3 (s, 1H), 13.7 (s, 1H).

As the paragraph descriping shows that 913287-12-4 is playing an increasingly important role.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/183928; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles