Category: 91348-45-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91348-45-7,Ethyl 3-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

91348-45-7, Intermediate 22a : Ethyl 3-bromo-1 -{[4′-(methoxycarbonyl)-4- methylbiphenyl-3-yl]methyl}-1 H-indole-2-carboxylateTo 68.3 g (0.266 mol) of methyl 3′-(hydroxymethyl)-4′-methylbiphenyl- 4-carboxylate in 1.0 L EtOAc was added at 100C 20.5 ml_ (0.280 mol) SOCI2 and 1 ml_ pyridine. The solution was then stirred at room temperature for 12 hrs then washed with 500 ml_ 1.0 N HCI (aq), 500 ml_ sat. NaHCO3 (aq) and 500 ml_ brine then dried over Na2SO4 and concentrated. To 750 mg (2.71 mmol) of this residue was added 660mg (2.46 mmol) of ethyl 3-bromo-1 H- indole-2-carboxylate in 8 ml_ DMF followed by 850 mg (6.16 mmol) K2CO3 and the mixture stirred at 7O0C for 4 hrs. The solution was cooled and 100 ml_ EtOAc was added. The solution was washed with three 25 ml_ portions of H2O and 25 ml_ brine then dried over Na2SO4, concentrated, and purified by silica gel chromatography (120 grams of silica gel eluting with 0-20% EtOAc in hexanes over 45 minutes) to give 1.02 g (82%) of ethyl 3-bromo-1 -{[4′- (methoxycarbonyl)-4-methylbiphenyl-3-yl]methyl}-1H-indole-2-carboxylate as white solid: 1 H NMR (400 MHz, CDCI3). delta 7.93 (d, 2H, J = 8.5 Hz), 7.74 (d, 1 H, J = 7.9 Hz), 7.40-7.22 (m, 7H), 6.54 (s, 1 H), 5.79 (s, 2H), 4.34 (q, 2H, J = 7.4 Hz), 3.87 (s, 3H), 2.46 (s, 3H), 1.32 (t, 3H, J = 7.4 Hz)

As the paragraph descriping shows that 91348-45-7 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORAITON; OPLINGER, Jeffrey Alan; WO2008/28118; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

91348-45-7, Ethyl 3-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91348-45-7, EXAMPLE 5OB ethyl 3-ortho-tolyl-lH-indole-2-carboxylateA mixture of EXAMPLE 31B (1.08 g), ortho-tolylboronic acid (1.1 g), (1,1′- bis(diphenylphosphino)ferrocene)dichloropalladium(II) (140 mg) in dimethoxyethane:2N aqueous Na2CO3 (25 mL:5 mL) was stirred under nitrogen at 😯 C for 16 hours, diluted with ethyl acetate and was washed with water and brine. The organic phase was dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash chromatography on silica gel with 0-10% ethyl acetate/hexanes.

The synthetic route of 91348-45-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; WO2008/130970; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

91348-45-7, Ethyl 3-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,91348-45-7

General procedure: To a mechanically stirred mixture of (1) (27.97 mmol),K2CO3 (83.91 mmol) and dry DMF (50 mL), benzyl bromideor 4-chlorobenzyl bromide (30.77 mmol) was addeddropwise respectively. After stirring for 48 h, the solutionwas filtered and the filtrate was extracted with ethyl acetate(3 ¡Á 20 mL). The combined organic extracts were washedwith water (50 mL) and brine (50 mL), dried over sodiumsulfate and concentrated. The crude product was purified bycolumn chromatography using a mixture of ethyl acetate/hexane (20:80) as eluent to give the title compounds (2a/b).

91348-45-7 Ethyl 3-bromo-1H-indole-2-carboxylate 4715017, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Kaur, Jeewanjot; Singh, Amanjot; Singh, Gagandeep; Verma, Raman K.; Mall, Rajiv; Medicinal Chemistry Research; vol. 27; 3; (2018); p. 903 – 914;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

91348-45-7, Ethyl 3-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,91348-45-7

Production Example 9-1 ethyl 3-(3-furyl)-1H-indole-2-carboxylate A toluene-ethanol mixed solvent (1:1, 60 mL) containing commercially available ethyl 3-bromo-1H-indole-2-carboxylate (1.5 g), 3-furylboronic acid (939 mg), tetrakis(triphenylphosphine)palladium(0) (1.29 g) and a 1 M aqueous sodium carbonate solution (11.2 mL) was heated under reflux overnight at 100 C. under a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure, and to the residue, water was added and the solution was extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1), whereby the title compound (340 mg) was obtained as a pale yellow solid.

91348-45-7 Ethyl 3-bromo-1H-indole-2-carboxylate 4715017, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles