Category: 914348-94-0

914348-94-0, tert-Butyl 3-formyl-5-methyl-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

914348-94-0, General procedure: To the stirred mixture of substituted indole (8(aec), 0.50 g,2.0 mmol) and substituted isoxazole amine (5(aee), 0.35 g,2.0 mmol) in methanol (5.0 ml) was added 4 A molecular sieves(0.50 g) and catalytic amount of acetic acid. The above reactionmixture was allowed to stir for 1 h at room temperature. followedby the portion wise addition of sodium cyanoborohydride (0.32 g,5.0 mmol) was added portionwise at room temperature and thereaction mixture was allowed to stir for 16 h. Solvent was removed under reduced pressure and then diluted with dichloromethane,which was washed with 10% sodium bicarbonate solution. Theobtained DCM layer was dried over sodium sulphate and distilledunder vacuum to obtain crude 9(aeo), which was further purifiedby column chromatography using ethyl acetate and hexane mixture(80:20) to obtain pure compounds in 80% yield.

The synthetic route of 914348-94-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pedada, Srinivasa Rao; Yarla, Nagendra Sastry; Tambade, Pawan J.; Dhananjaya, Bhadrapura Lakkappa; Bishayee, Anupam; Arunasree, Kalle M.; Philip, Gundala Harold; Dharmapuri, Gangappa; Aliev, Gjumrach; Putta, Swathi; Rangaiah, Gururaja; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 289 – 297;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

914348-94-0, tert-Butyl 3-formyl-5-methyl-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

914348-94-0, General procedure: To the stirred mixture of substituted indole (8(aec), 0.50 g,2.0 mmol) and substituted isoxazole amine (5(aee), 0.35 g,2.0 mmol) in methanol (5.0 ml) was added 4 A molecular sieves(0.50 g) and catalytic amount of acetic acid. The above reactionmixture was allowed to stir for 1 h at room temperature. followedby the portion wise addition of sodium cyanoborohydride (0.32 g,5.0 mmol) was added portionwise at room temperature and thereaction mixture was allowed to stir for 16 h. Solvent was removed under reduced pressure and then diluted with dichloromethane,which was washed with 10% sodium bicarbonate solution. Theobtained DCM layer was dried over sodium sulphate and distilledunder vacuum to obtain crude 9(aeo), which was further purifiedby column chromatography using ethyl acetate and hexane mixture(80:20) to obtain pure compounds in 80% yield.

The synthetic route of 914348-94-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pedada, Srinivasa Rao; Yarla, Nagendra Sastry; Tambade, Pawan J.; Dhananjaya, Bhadrapura Lakkappa; Bishayee, Anupam; Arunasree, Kalle M.; Philip, Gundala Harold; Dharmapuri, Gangappa; Aliev, Gjumrach; Putta, Swathi; Rangaiah, Gururaja; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 289 – 297;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.914348-94-0,tert-Butyl 3-formyl-5-methyl-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.

914348-94-0, General procedure: To the stirred mixture of substituted indole (8(aec), 0.50 g,2.0 mmol) and substituted isoxazole amine (5(aee), 0.35 g,2.0 mmol) in methanol (5.0 ml) was added 4 A molecular sieves(0.50 g) and catalytic amount of acetic acid. The above reactionmixture was allowed to stir for 1 h at room temperature. followedby the portion wise addition of sodium cyanoborohydride (0.32 g,5.0 mmol) was added portionwise at room temperature and thereaction mixture was allowed to stir for 16 h. Solvent was removed under reduced pressure and then diluted with dichloromethane,which was washed with 10% sodium bicarbonate solution. Theobtained DCM layer was dried over sodium sulphate and distilledunder vacuum to obtain crude 9(aeo), which was further purifiedby column chromatography using ethyl acetate and hexane mixture(80:20) to obtain pure compounds in 80% yield.

The synthetic route of 914348-94-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pedada, Srinivasa Rao; Yarla, Nagendra Sastry; Tambade, Pawan J.; Dhananjaya, Bhadrapura Lakkappa; Bishayee, Anupam; Arunasree, Kalle M.; Philip, Gundala Harold; Dharmapuri, Gangappa; Aliev, Gjumrach; Putta, Swathi; Rangaiah, Gururaja; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 289 – 297;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles