916179-87-8, 3-Bromoindole-5-carboxylic Acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,916179-87-8
To a mixture of 50 (1.0 g, 4.2 mmol) and K2CO3 (0.865 g, 1.5 eq.) inDMF (15 mL) was added CH3I (337 muL, 1.3 eq.) at room temperature (Scheme 9). After stirring for 1.2 hours, the reaction was quenched with a saturated solution of NH4Cl (10 mL). The aqueous layer was extracted with ethyl acetate (3 x 15 mL) and the combined organic layer was dried with MgStheta4, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography (15% ethyl acetate in hexane) to afford 51 (1.01 g, 95%). 1H NMR (DMSO): 3.87 (s, 3H), 7.53 (d, IH, J=8.6), 7.71 (s, IH), 7.35 (dd, IH, J=8.6, 1.5), 7.64(s, IH), 11.41 (s, IH).
The synthetic route of 916179-87-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; QUEEN’S UNIVERSITY AT KINGSTON; WO2006/125324; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles