93490-31-4, 4-Chloro-6-methoxy-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
93490-31-4, 4-Chloro-6-methoxy-1H-indole (250 mg, 1.38 mmol) was dissolved in DCM (5 mL) and pyridine (0.334 mL, 4.13 mmol) was added. The solution was cooled to ~ 0 ^C, and a solution of trichloroacetyl chloride (0.231 mL, 2.07 mmol) in DCM (1 mL) was added over the course of about 30 min. The cooling bath was removed and the reaction mixture was stirred at rt overnight. All the volatiles are removed under reduced pressure. The mixture was then stirred with ethanol-water (1:1, 15 mL) for 10 min, and the product was filtered off and dried. Further purification by silica gel flash chromatography eluting with 0-100% ethyl acetate gradient in hexanes to give 2,2,2-trichloro-1-(4-chloro-6-methoxy-1H-indol-3- yl)ethanone (320 mg).
As the paragraph descriping shows that 93490-31-4 is playing an increasingly important role.
Reference：
Patent; VTV THERAPEUTICS LLC; ANDREWS, Robert, Cart; POLISETTI, Dharma, Rao; VICTORY, Samuel; SUNDERMANN, Kurt; REN, Tan; (190 pag.)WO2018/9539; (2018); A1;,
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