938465-52-2 | - Indole Building Blocks

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As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.938465-52-2,1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide,as a common compound, the synthetic route is as follows.

To a solution of 4-(4-fluorophenyl)- 1 -oxa-4, 8-diazaspiro[5. Sjundecan-5-one (120 mg, 0.45 mmol) in NMP (3 mL) was added 1-chloro-5H-pyrido[4,3-bjindole-4-carboxamide (123 mg, 0.Smmol) and DIEA (174 mg, 1.35 mmol), and the mixture was heated under microwave irradiation for 1.5 h at 150 C.The mixture was purified with prep-HPLC to give 1-(4-(4-fluorophenyl)-5 -oxo- 1 -oxa-4, 8-diazaspiro[5.5j undecan-8-yl)-5H-pyrido [4,3-bj indole-4- carboxamide. ?H NMR (400 MHz, CD3OD) 3 8.51 (s, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.82 (d, J=8.0 Hz, 1H), 7.62 (t, J=7.7 Hz, 1H), 7.54 – 7.44 (m, 1H), 7.31 – 7.23 (m, 2H), 7.14 – 7.06 (m, 2H), 4.40 (d, J=13.3 Hz, 1H), 4.27 – 4.14 (m, 2H), 4.00 – 3.90 (m, 1H), 3.80 – 3.66 (m, 3H), 3.64- 3.52 (m, 1H), 2.54 – 2.39 (m, 1H), 2.38 – 2.22 (m, 2H), 1.94 – 1.79 (m, 1H) ppm., 938465-52-2

As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role.

Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple exploration of 938465-52-2

As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role.

938465-52-2, 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,938465-52-2

A mixture of 4-((benzyloxy)methyl)-2-methyl-2,7-diazaspiro[4. s1 decan- 1-one(118 mg, 0.407 mmol), 1-chloro-5H-pyrido[4,3-bjindole-4-carboxamide (100 mg, 0.407 mmol)and DIPEA (0.3 mL, 1.63 mmol) in 1-methylpyrrolidin-2-one (3 mL) was stirred in a microwave at 150 C for 2 h. To the mixture was added water (10 mL). The mixture was extracted withDCM/i-PrOH (3:1, 20 mL )< 3). The combined organic layers were washed with brine (10 mL), dried over sodium sulfate, filtered and concentrated to afford the crude product, which waspurified by silica gel column chromatography (THF / PE = 30% 80 %) to give 1-(4-((benzyloxy)methyl)-2-methyl- 1 -oxo-2,7-diazaspiro [4.51 decan-7-yl)-5H-pyrido [4,3-bj indole-4-+carboxamide as a solid. MS: 498.2[M+Hj As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role. Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Downstream synthetic route of 938465-52-2

The synthetic route of 938465-52-2 has been constantly updated, and we look forward to future research findings.

A mixture of l-chloro-5H-pyrido[4,3-6]indole-4-carboxamide in cone. NH4OH (0.07 M) was heated in a microwave reactor at 1600C for 1 h in a sealed tube. The reaction mixture was cooled to room temperature and partitioned between THF/EtOAc and saturated NaHCO3. After separation of the organic phase, the aqueous phase was extracted again with THF/EtOAc, and the combined organic phases were washed with brine, dried over Na2SCXj and filtered. After evaporation of the organic solvents, the residue was purified by flash chromatography (0-10% MeOH in EtOAc) to provide the title compound as an off-white solid.1H NMR (DMSO-d6) delta 11.50 (IH, s), 8.50 (IH, s), 8.30 (IH, d), 7.85 (IH, br s), 7.75 (IH, d), 7.35 (IH, t), 7.20 (IH, t), 7.15 (IH, br s), 6.80 (2H, br s).

The synthetic route of 938465-52-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK & CO., INC.; MERCK FROSST CANADA LTD.; WO2007/61764; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple exploration of 938465-52-2

As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role.

938465-52-2, 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

938465-52-2, To a solution of Intermediate 1(500 mg, 2.04 mmol) in CH3COOH (20 mL) was added NBS (381 mg, 2.14 mmol) and then stirring at rt overnight. The mixture was poured intoH20 (100 mL), filtered to afford 8-bromo-1-chloro-5H-pyrido[4,3-bjindole-4- carboxamide.1HNMR (300MHz, DMSO-d6) oe12.30 (s, 1H), 8.80 (s,1 H),8.46 (s, 1 H), 8.35- 8.38 (m, 1 H), 7.69-7.82 (m, 3 H) ppm.

As the paragraph descriping shows that 938465-52-2 is playing an increasingly important role.