93957-49-4 | - Indole Building Blocks

Downstream synthetic route of 93957-49-4

The synthetic route of 93957-49-4 has been constantly updated, and we look forward to future research findings.

93957-49-4, 3-(4-Fluorophenyl)-1-isopropyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

93957-49-4, EXAMPLE 1 3-(4-Fluorophenyl)-1-isopropyl-1H-indole-2-carbaldehyde 5.77 g (78.96 mmol) of DMF are weighed into a 100 ml three-necked round-bottomed flask, equipped with a magnetic stirrer, thermometer, dropping funnel, reflux condenser and nitrogen delivery line, and cooled, with stirring, to 3 C. 12.11 g (78.96 mmol) of phosphorus oxychloride are then slowly added dropwise so that the internal temperature does not exceed 10 C. The reaction mixture is then heated to 80 C. and 10 g (39.48 mmol) of 3-(4-fluorophenyl)-1-isopropyl-1H-indole, dissolved in 10 ml of DMF, are added dropwise in the course of 30 min. Stirring is subsequently carried out for 1.5 hours at that temperature. Cooling and dilution with 10 ml of DMF are then carried out. The reaction mixture is transferred into a dropping funnel and, with stirring, slowly added dropwise at 40 C. to 10 g (0.25 mol) of sodium hydroxide in 200 ml of water. The aqueous phase is extracted four times with 50 ml of toluene and the combined organic phases are washed six times with 100 ml of water. Subsequently, 10 g of silica gel are added, the mixture is stirred for 1 hour and filtration is carried out, followed by washing three times with 50 ml of toluene and concentration by evaporation. 10.17 g of a brown oil are obtained, which is dissolved in 100 ml of hexane under reflux. 10 g of silica gel are added, and filtration is carried out while hot, followed by washing three times with 50 ml of hot hexane. The filtrate is concentrated by evaporation and the residue is recrystallized from 94% ethanol. Slightly beige crystals having a melting point of from 89.5 to 91 C. are obtained.

The synthetic route of 93957-49-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wolleb, Annemarie; Wolleb, Heinz; US2003/166946; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Some tips on 93957-49-4

As the paragraph descriping shows that 93957-49-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93957-49-4,3-(4-Fluorophenyl)-1-isopropyl-1H-indole,as a common compound, the synthetic route is as follows.,93957-49-4

The reaction and post treatment were conducted in the same manner as in Example 8 except that acids shown in Table 1 were used instead of phosphorus oxychloride, the amount of glacial acetic acid was 6 mL and conditions shown in Table 1 were used, to obtain methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). The results are shown in Table 1.

As the paragraph descriping shows that 93957-49-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP1666440; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Analyzing the synthesis route of 93957-49-4

93957-49-4 3-(4-Fluorophenyl)-1-isopropyl-1H-indole 736229, aindole-building-block compound, is more and more widely used in various.

Temperature 25 ¡À 5 C, to a 2000L reactor in 1,2 Dichloroethane 504.0kg (5mL / g), the main material of 3- (4-fluorophenyl) -1-isopropyl–1H- indole 80kg (315.8mol, 1.0equiv. ) And N- bromosuccinimide 67.5kg (379.0mol, 1.2 equiv.). The reaction system was heated to reflux, HPLC detected until the end of the reaction. The system pushed A saturated aqueous solution of sodium bisulfite in 480.0kg (5mL / g) to terminate the reaction. Standing, liquid separation, The organic phase was concentrated, then ethanol was added 126.4kg (2mL / g) was recrystallized from 2-bromo-halo 3- (4-fluorophenyl) -1-isopropyl–1H- indole 89.2kg, 96.0% pure liquid, yield 85.0%.

93957-49-4 3-(4-Fluorophenyl)-1-isopropyl-1H-indole 736229, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; ASYMCHEM INC; ASYMCHEM LIFE SCIENCE TIANJIN CO LTD; ASYCHEM PHARMACEUTICALS TIANJIN CO LTD;; ASYMCHEM LAB FUXIN INC; Jilin Asymchem Laboratories Co., Ltd; Hong, Hao; Ma, Jian Guo; Li, jiuyuan; Huang, Jun; (12 pag.)CN103342721; (2016); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

New learning discoveries about 93957-49-4

The synthetic route of 93957-49-4 has been constantly updated, and we look forward to future research findings.

Examples 19 to 20 The reaction and post treatment were conducted in the same manner as in Example 14 except that acids shown in Table 3 were used instead of phosphorus oxychloride and the reaction time was 19 hours, to obtain methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). The results are shown in Table 3.

The synthetic route of 93957-49-4 has been constantly updated, and we look forward to future research findings.