942-24-5, Methyl indole-3-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Hydrazine hydrate (99%, 2 mL, 40 mmol) was added in one portion to methyl indole-3-carboxylate 1 (10 mmol, 1.75 g) dissolved in dry ethanol (50 mL) at room temperature, and the resulting solution was heated under reflux for 8 h. The reaction mixture was allowed to cool and the solid obtained was filtered off and washed with a small quantity of ethanol to give the 1H-indole-3-carbohydrazide 2. Yield: 1.66 g, 95%, white solid, mp 234-236C; 1H NMR (600 MHz, DMSO-d6): delta 4.34 (s, 2H), 7.10-7.11 (m, 2H), 7.43 (t, J 3.6 Hz, 2H), 7.98 (s, 1H), 8.15 (d, J 7.2 Hz, 3H), 9.18 (s, 1H),11.55 (s,1H); EI-MS:m/z (%) 175 (M, 22),144 (100),116 (17), 89 (11)., 942-24-5
The synthetic route of 942-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Ming-Zhi; Mulholland, Nick; Beattie, David; Irwin, Dianne; Gu, Yu-Cheng; Chen, Qiong; Yang, Guang-Fu; Clough, John; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 22 – 32;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles