Category: 942-26-7

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,942-26-7

General procedure: A flask was charged with 5-chlorotryptamine hydrochloride (5 g, 0.0649 mol), 0.5 M hydrochloric acid(130 mL), and the substituted benzaldehyde (1.5 eq). The mixture was refluxed for 14 hr, cooled to roomtemperature, and vacuum filtered. The solid was resuspended in acetic acid (100 mL), stirred for 1 hr, andvacuum filtered. The solid was resuspended in ethyl acetate (100 mL), stirred for 1 hr, and vacuumfiltered to obtain the pure scaffold as a solid.

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Tikhmyanova, Nadezhda; Paparoidamis, Nicholas; Romero-Masters; Feng, Xin; Mohammed, Farheen Sultana; Reddy, Poli Adi Narayana; Kenney, Shannon C.; Lieberman, Paul M.; Salvino, Joseph M.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2259 – 2264;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-26-7,5-Chlorotryptamine hydrochloride,as a common compound, the synthetic route is as follows.,942-26-7

Step A: ethyl 1-({[2-(5-chloro-1H-indol-3-yl)ethyl]amino}carbonyl)cyclobutanecarboxylate 23.1 g of 5-chlorotryptamine hydrochloride, 17.3 g of monoethyl cyclobutanedicarboxylate, 36 ml of diisopropylethylamine and 33.7 g of O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate are stirred for 20 hours at ambient temperature in 200 ml of dichloromethane.. After washing with water, drying over sodium sulphate and filtering off the organic phase over Celite, evaporation under reduced pressure enables the expected product to be isolated.

The synthetic route of 942-26-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Les Laboratoires Servier; US6350757; (2002); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7,942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A flask was charged with 5-chlorotryptamine hydrochloride (5 g, 0.0649 mol), 0.5 M hydrochloric acid(130 mL), and the substituted benzaldehyde (1.5 eq). The mixture was refluxed for 14 hr, cooled to roomtemperature, and vacuum filtered. The solid was resuspended in acetic acid (100 mL), stirred for 1 hr, andvacuum filtered. The solid was resuspended in ethyl acetate (100 mL), stirred for 1 hr, and vacuumfiltered to obtain the pure scaffold as a solid.

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Tikhmyanova, Nadezhda; Paparoidamis, Nicholas; Romero-Masters; Feng, Xin; Mohammed, Farheen Sultana; Reddy, Poli Adi Narayana; Kenney, Shannon C.; Lieberman, Paul M.; Salvino, Joseph M.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2259 – 2264;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

942-26-7, Triethylamine (1.93 mL; 13.78 mmol) was added at 0 C. to a mixture of 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (1.3 g; 5.51 mmol) and 3-(chloromethyl)benzoyl chloride (1.13 g; 5.79 mmol) in dichloromethane (75 mL). The mixture was stirred for 20 minutes at room temperature and was evaporated to dryness. The residue was purified by flash chromatography on silica gel (eluent 2 to 20% ethyl acetate in dichloromethane) to furnish 1.45 g (76%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3-(chloromethyl)benzamide as a white solid. [0561] ESI/APCI(+): 347 (M+H), 369 (M+Na); ESI/APCI(-): 345 (M-H). [0562] 1H NMR (DMSO-d6) delta 11.04 (s, 1H); 8.68 (t, 1H); 7.91 (s, 1H); 7.80 (d, 1H); 7.63 (s, 1H); 7.59 (d, 1H); 7.47 (t, 1H); 7.35 (d, 1H); 7.28 (s, 1H); 7.06 (dd, 1H); 4.82 (s, 2H); 3.52 (q, 2H), 2.93 (t, 2H).

As the paragraph descriping shows that 942-26-7 is playing an increasingly important role.

Reference£º
Patent; Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Veronica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick; US2013/274260; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-26-7,5-Chlorotryptamine hydrochloride,as a common compound, the synthetic route is as follows.,942-26-7

Step A: 1-[2-(5-Chloro-1H-indol-3-yl)ethyl]piperidin-2-one To a solution of 100 g of 5-chlorotryptamine hydrochloride in 1.4 litres of 2-methoxyethanol there are added 60 g of Na2CO3. The reaction mixture is stirred at reflux under nitrogen. A solution of 111.2 g of 5-bromovalerate in 200 ml of 2-methoxyethanol is added dropwise over a period of 5-6 hours and the mixture is heated at reflux for 24 hours. After cooling, the reaction mixture is filtered over Celite and the filtrates are concentrated under reduced pressure. The oil is extracted with 500 ml of CH2Cl2 and 3000 ml of water. The organic phases are washed with saturated sodium chloride solution, then dried over Na2SO4 and concentrated under reduced pressure. The solid is recrystallized from a 9/1 acetone/pentane mixture to yield 107 g of the expected product. Melting point. 155 C. Mass spectrometry (EI, m/z): 276.8 (M+).

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; LES LABORATOIRES SERVIER; US2009/298813; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-26-7,5-Chlorotryptamine hydrochloride,as a common compound, the synthetic route is as follows.,942-26-7

EXAMPLE 113 – PREPARATION of N-(2-(5-Chloro-1 H-indol-3-yl)ethyl)-4-(3- fluorophenoxy)benzamide. A solution of 4-(3-fluorophenoxy)benzoic acid(0.180 g, 0.775 mmol), 2-(5-chloro-1 H- indol-3-yl)ethanamine hydrochloride (0.180 g; 0.775 mmol), HATU (0.324 g; 0.852 mmol) and Nu,Nu-diisopropylethylamine (0.334mL; 1.94 mmol) in DMF (5 mL), was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and sodium hydrogen sulfate, the organic layer was washed with sodium carbonate, brine, dried and concentrated under reduced pressure. The crude mixture was purified by flash chromatography on silica (eluent 2 to 20 % ethyl acetate in dichloromethane and 20 to 100% ethyl acetate in heptane ) to yield 0.065 g (20%) of the title compound as a white solid.ESI/APCI(+):409 (M+H); ESI/APCI(-): 407 (M-H).

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D; REMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; ALLASIA, Sara; MARCHAND, Arnaud; KILONDA, Amuri; CHALTIN, Patrick; WO2012/80221; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

942-26-7, General procedure: Commercial tryptamine hydrochloride (4.9 g, 24.9 mmol, 1 eq) and glyoxylic acid (2.6 g, 27.4 mmol, 1.1 eq) were dissolved in 78 mL H2O,and then the solution of KOH (1.38 g, 24.9 mmol, 1 eq) in 6 mL H2O was added dropwise. The mixture was stirredfor 1h and the white precipitate was collected by filtration. The precipitate was dissolved in 78 mL H2O and thesolution was added conc. HCl (6.6 mL) at room temperature. After stirring for one hour under reflux, the solutionwas added 6.6 mL conc. HCl again and stirred for another 0.5 h under reflux. After cooling to r.t., the light-greencrystal was obtained and collected by filtration and then dissolved in 78 mL H2O. The solution was basified by 20%KOH until pH > 13, and the white precipitate was filtered off and washed with water three times to the titlecompound S16a (3.1 g, 73%).

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Zheng, Hongbo; Li, Lin; Sun, Bin; Gao, Yun; Song, Wei; Zhao, Xiaoyu; Gao, Yanhui; Xie, Zhiyu; Zhang, Nianzhao; Ji, Jianbo; Yuan, Huiqing; Lou, Hongxiang; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 30 – 38;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles