Category: 950846-89-6

Erdemir, Serkan published the artcile< Fluorometric dual sensing of Hg2+ and Al3+ by novel triphenylamine appended rhodamine derivative in aqueous media>, Application of C30H36N4O2, the main research area is triphenylamine appended rhodamine derivative mercury detection density functional theory.

Triphenylamine appended rhodamine (named probe TR) was built as a selective fluorescent probe for Al3+ and Hg2+ ions through different sensing mechanisms. TR demonstrated a distinct fluorescence enhancing at 501 and 580 nm towards Al3+ and Hg2+ ions due to the “”PET-off”” (Photoinduced electron transfer-off) and “”FRET-on”” (Fluorescence resonance energy transfer-on) processes, resp. The binding modes between TR with Al3+ and Hg2+ were found to be 1:1 by job plot anal. The limits of detection of TR for sensing Al3+ and Hg2+ are down to 71.8 nM and 0.48 μM, resp. At the same time, the complexation details between the probe TR with Al3+ and Hg2+ ions were investigated by FTIR, 1HNMR experiments and DFT calculations Moreover, simple test papers coated probe TR were successively developed for the rapid monitoring of Al3+ and Hg2+ ions.

Sensors and Actuators, B: Chemical published new progress about Density functional theory. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application of C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, Zi-ying; Xu, Zhong-yong; Yan, Jin-wu; Li, Yafang; Kou, Qiuye; Zhang, Lei published the artcile< Development of rhodamine-based fluorescent probes for sensitive detection of Fe3+ in water: spectroscopic and computational investigations>, Category: indole-building-block, the main research area is rhodamine iron water fluorescent probe.

Four novel rhodamine-based fluorescent probes (RE1-RE4) were designed and synthesized for sensitive detection of Fe3+ in H2O. RE1-RE4 exhibited low detection limits in the range of 18.6 nM to 29.4 nM. The binding modes of the probes (RE1-RE4) with Fe3+ are 1:1 stoichiometry of the complexes by Job’s plot and also their complexing ability was determined using the binding constants (RE2 > RE4 > RE3 > RE1). RE2 was selected to study the proposed binding mechanism with Fe3+ by ESI-MS, 1H NMR and DFT calculations Also, RE2 was further used to detect Fe3+ in living cells and real H2O samples, indicating its promising prospect in biol. and environmental fields.

New Journal of Chemistry published new progress about Fluorescence spectroscopy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Category: indole-building-block.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Song, Fan; Yang, Chao; Liu, Haibo; Gao, Zhigang; Zhu, Jing; Bao, Xiaofeng; Kan, Chun published the artcile< Dual-binding pyridine and rhodamine B conjugate derivatives as fluorescent chemosensors for ferric ions in aqueous media and living cells>, Formula: C30H36N4O2, the main research area is pyridine rhodamine conjugate derivative fluorescence chemosensor ferric ion.

Two new pyridine-type rhodamine B chemosensors (RBPO and RBPF) used to detect Fe3+ have been designed and synthesized, and the sensing behavior towards various metal ions was evaluated via UV-vis and fluorescence spectroscopic techniques. Both RBPO and RBPF not only have good spectral responses to Fe3+ in an EtOH/H2O solution (3 : 1, volume/volume, HEPES, 0.5 mM, pH = 7.33) with low detection limits and high binding constants, but also suffer from less interference from common metal cations. The two chemosensors are further proven to be practical in sensitively monitoring trace Fe3+ in real water specimens. Intracellular imaging applications demonstrated that RBPO and RBPF can be used as two fluorescent chemosensors for the detection of Fe3+ in living human breast adenocarcinoma (MCF-7) cells.

Analyst (Cambridge, United Kingdom) published new progress about Colorimetric sensors. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gao, Zhigang; Kan, Chun; Liu, Haibo; Zhu, Jing; Bao, Xiaofeng published the artcile< A highly sensitive and selective fluorescent probe for Fe3+ containing two rhodamine B and thiocarbonyl moieties and its application to live cell imaging>, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is iron ion fluorescent probe rhodamine B thiocarbonyl moiety bioimaging.

A novel turn-on rhodamine B-based fluorescent chemosensor (RBCS) was designed and synthesized by reacting N-(rhodamine B)lactam-1,2-ethylenediamine and carbon disulfide. Upon addition of Fe3+ in EtOH/H2O solution (2:1, volume/volume, HEPES buffer, 0.6 mM, pH 7.20), the RBCS displayed a significant fluorescence enhancement at 582 nm and a dramatic color change from colorless to pink, which can be detected by the naked eye. Significantly, the RBCS exhibited a highly selective and sensitive ability toward Fe3+. The detection limit of the probe was 2.05 × 10-7 M. Job’s plot indicated the formation of 1:1 complex between the RBCS and Fe3+. Moreover, the practical use of the RBCS is demonstrated by its application in the detection of Fe3+ in HeLa cells.

Tetrahedron published new progress about Biocompatibility. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Das, Sujoy; Rissanen, Kari; Sahoo, Prithidipa published the artcile< Rare Crystal Structure of Open Spirolactam Ring along with the Closed-Ring Form of a Rhodamine Derivative: Sensing of Cu2+ Ions from Spinach>, Name: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is crystal structure spirolactam ring copper ion spinach.

Crystal structures of a rhodamine derivative in its closed and open spirolactam ring form combined with a selective and sensitive detection of Cu2+ ion at micromolar range in neutral medium. The chemosensing properties of the probe through a pentacoordinate Cu2+ ion were proven by spectroscopic and theor. anal. The spirolactam ring opening as the Cu2+ selective sensor was applied to spinach (Spinacia oleracea) to estimate the accumulation of copper as copper(II) into the plant.

ACS Omega published new progress about Crystal structure (of quinoline rhodamine acetamide). 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Name: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Pipattanawarothai, Athit; Trakulsujaritchok, Thanida published the artcile< Hybrid polymeric chemosensor bearing rhodamine derivative prepared by sol-gel technique for selective detection of Fe3+ ion>, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is hybrid polymeric chemosensor rhodamine B derivative functionalized; ferric ion detection colorimetry.

To develop a reusable and selective colorimetric chemosensor for visual detection of ferric ion, a new rhodamine-based chelator (RB-UTES) was prepared The structural constitution and sensing property of RB-UTES were examined The chelator was sensitive and selective for recognition of ferric ion and could be covalently attached to poly(vinyl alc.) through siloxane linkage formed by the sol-gel reaction. The physicochem. properties and sensing behavior of the functional chemosensor films were studied. By simply soaking in aqueous media, the free-standing sensor film exhibited high selectivity and sensitivity to ferric ion and permitted the convenient detection by naked eye with prominent development of pink color throughout the film. The sensor film could return to its original color by washing with 0.1M ethylenediamine allowing repeated cycles of detection. The combination of its anal. performance, simplicity of operation as well as reusability made this functional sensor promising for the use in aqueous solutions and real samples.

Dyes and Pigments published new progress about Colorimetry. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Zhipeng; Xiong, Wei; He, Xiaojun; Qi, Xiaoliang; Ding, Feng; Shen, Jianliang published the artcile< A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells>, COA of Formula: C30H36N4O2, the main research area is rhodamine B fluorescent probe glutathione bioimaging.

The aim of this study was to overcome the reported shortcomings of the glutathione (GSH) detection of rhodamine-based fluorescent probes, such as poor selectivity to thiol groups and reversible unstable covalent binding with the thiol groups. Here, the authors have developed a simple and specific fluorescent probe based on rhodamine B, which can be used to selectively detect GSH in solution and perform bioimaging in living cells. This design strategy uses a specific reaction between allenamide and the GSH thiol group, which proceeds rapidly in a phosphate buffer/tetrahydrofuran (PBS/THF) mixture with specific selectivity, and forms a stable and irreversible conjugate. The combined simplicity and specificity of the recognition process enables it to serve as a fluorescent probe for detecting GSH level changes in living cells. Such a new recognizing strategy thus may open a new window for its further application in detecting GSH levels both in vitro and in vivo.

Analyst (Cambridge, United Kingdom) published new progress about Fluorescence. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, COA of Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kim, Jaehyun; Jeon, Joa; Wang, Cong; Chang, Gyu Tae; Park, Jungyul published the artcile< Asymmetric Nanochannel Network-Based Bipolar Ionic Diode for Enhanced Heavy Metal Ion Detection>, Safety of 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is asym nanochannel bipolar ionic diode heavy metal ion detection; Biosensor; Bipolar ionic diode; Geometrical optimization; Ion current rectification; Ionic junction.

A higher rectification degree in ionic diodes is required to achieve better performance in applications. Nonetheless, the active geometrical change that is critical for inducing elec. potential asymmetry is difficult to realize in typical ionic diodes because of the intrinsic limitation of the fabrication method. Here, we propose a nanochannel-network-based bipolar diode with a high rectification degree of ≈1600-the highest value realized until now, to the best of our knowledge. Such a high rectification is obtained based on the synergetic effect of the bipolar surface charge and the optimization of the microchannel through exptl. studies and multiphysics numerical simulations. It induces ion concentrations at the heterogeneous junction based on the accumulation effect under the forward potential bias. In particular, this proposed mol. concentration occurs in the ohmic region without vortex and instability that is inevitable at the conventional nano-electrokinetic concentration Combining this accumulation with the horizontally aligned configuration of the nanochannel network membrane (NCNM), a highly sensitive and quant. mercury ion (Hg2+) sensor based on a fluorescent signal is fabricated that allows direct measurement using a general fluorescent microscope. The detection limit of Hg2+ is 10 pM, which is ≈10 times lower than the best detection limit realized so far (≈100 pM) in fluorescent dye-based detection. This demonstrates the potential of asym. NCNM for high-performance ion transport in applications such as energy conversion, based on its design and material flexibility.

ACS Nano published new progress about Convective flow. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Safety of 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mallick, Debajani; Bag, Bamaprasad published the artcile< Altered metal ion selectivity in signalling with heterocyclic tripodal receptor appended rhodamine-B derivatives>, Formula: C30H36N4O2, the main research area is metal ion selectivity fluorescent sensor rhodamine B derivative.

The rhodamine derivatives (2-7) were shown to exhibit metal ion complexation induced photophys. ‘turn-on’ signalling responses, where the selectivity in signalling were driven by stereo-electronic environment of the receptor units that structurally differ as derivatization of different heterocyclic units. The chromogenic and fluorogenic spectral enhancements of two order higher in logarithmic scale were observed in these tripodal receptor incorporated amino-ethyl-rhodamine probes, where substitution of a 2-[2-[(thiophen-2-yl-methyl)-(2-pyridinylmethyl)-amino]-ethyl]- (as in 3) has shown selectivity for Hg(II) ion, a 2-[2-[(furan-2-yl-methyl)-(2-pyridinyl methyl)-amino]-ethyl]- (as in 5) for Al(III) ion and a 2-[2-[(phen-2-ylmethyl)-(2-pyridinylmethyl)-amino]-ethyl]- (as in 7) for Fe(III) ion resp. The higher order of association constants (log Ka > 9.0) of complexation, high sensitivity of detection(LOD < 2 nM) and higher rate of interaction between probe and metal ion (k ∼ 0.001 s-1) have showed potential of these probes in selective detection of corresponding metal ions. In general, the investigations on complexation induced photophys. signalling in these probes in terms of selectivity and sensitivity of detection, association constants of complex formation, reversibility in signalling, execution at different pH range, kinetics of spiro-ring opening and theor. structure elucidation have therefore put insights on their coordination mediated stereo-electronic environment to establish a rationality in structure-function correlation. Dyes and Pigments published new progress about Density functional theory. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Kun-Peng; Zheng, Wen-Jun; Lei, Yang; Zhang, Si-Jie; Zhang, Qi; Chen, Shaojin; Hu, Zhi-Qiang published the artcile< A thiophene-rhodamine dyad as fluorescence probe for ferric ion and its application in living cells imaging>, Category: indole-building-block, the main research area is thiophene rhodamine dyad fluorescence probe ferric ion cell imaging.

A thiophene-rhodamine dyad (BYY) was easily synthesized as a fluorescence probe from 2-thiopheneacetic acid and N-(rhodamine-B)lactam-ethylenediamine. The probe showed high response speed and sensitivity toward Fe3+ in ethanol/water (2/3, volume/volume, pH = 7.2), and the limit of detection was as low as 10-7 M. From the Job’s plot, mass spectrum, 1H NMR spectra and the theor. calculation, the 1:2 complex ratio of Fe3+-probe was obtained and the response mechanism was determined Significantly, the reversible binding of BYY to Fe3+ was achieved through the strong Fe3+ affinity of Na4P2O7, and the probe showed well antijamming abilities in the presence of common metal ions. Moreover, the probe was cell-permeable and could sensitively response to Fe3+ in living cells with satisfying resolution

Journal of Luminescence published new progress about Fluorescence. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Category: indole-building-block.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles