950846-89-6 | - Page 4 of 6 - Indole Building Blocks

Hu, Jiwen’s team published research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020-11-05 | 950846-89-6

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetric sensors. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Hu, Jiwen; Yu, Xili; Zhang, Xin; Jing, Changcheng; Liu, Tingting; Hu, Xiaochun; Lu, Senlin; Uvdal, Kajsa; Gao, Hong-Wen; Hu, Zhangjun published the artcile< Rapid detection of mercury (II) ions and water content by a new rhodamine B-based fluorescent chemosensor>, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is detection mercury ion water content fluorescent chemosensor; Fluorescence; Mercury; Rhodamine B; Water content.

A rhodamine B-based sensor (RS, I) was designed and synthesized by a combination of the spirolacton rhodamine B (fluorophore) and multidentate chelates (ionophore) with high affinity towards Hg2+. In the presence of Hg2+, the resulting red-orange fluorescence (under UV light) and naked eye red color of RS are supposed to be used for quant. and qual. measurement of Hg2+. Further fluorescent titration and anal. demonstrate that RS can selectively detect Hg2+ within 1 s with a low limit of detection (LOD) of 16 nM in acetonitrile media, meanwhile, the association constant (Ka) was calculated to be 0.32 x 105 M-1. More importantly, the resultant complex (RSHg) of RS and Hg2+ has also been successfully applied to detect limited water content in acetonitrile solution

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Peng, Xinwen’s team published research in Carbohydrate Polymers in 2019-07-15 | 950846-89-6

Carbohydrate Polymers published new progress about Antitumor agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Product Details of C30H36N4O2.

Peng, Xinwen; Liu, Peiwen; Pang, Bo; Yao, Yawen; Wang, Jiaxiu; Zhang, Kai published the artcile< Facile fabrication of pH-responsive nanoparticles from cellulose derivatives via Schiff base formation for controlled release>, Product Details of C30H36N4O2, the main research area is pH responsive nanoparticle cellulose derivative controlled drug release; Controlled release; Nanoparticles; Schiff base linkage; pH-stimuli responsiveness.

A controllable drug delivery system demonstrates a promising tool for diverse biomedical applications. In this work, a group of amphiphilic macromols. was designed and prepared via Schiff base reactions between 2,3-dialdehyde cellulose (DAC) with oleylamine and amino-containing compounds Benefiting from the self-assemble process of these amphiphilic macromols. in the poor solvent, a group of novel pH-responsive nanoparticles (NPs) were facilely fabricated by using nanopptn. dropping technique. The high amount of aldehyde groups on DAC chains enabled immobilization of tunable amounts of amine compounds (up to 1.67 mmol/g) in the NPs. Furthermore, the Schiff base bonds in NPs allowed the efficient release of the drug in acidic tumor microenvironment by cleaving the Schiff base linkages. This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.

Carbohydrate Polymers published new progress about Antitumor agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Product Details of C30H36N4O2.

Li, Man’s team published research in European Journal of Medicinal Chemistry in 2020-11-01 | 950846-89-6

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application In Synthesis of 950846-89-6.

Li, Man; Yuan, Lan; Chen, Yingying; Ma, Wenxiao; Ran, Fuxiang; Zhang, Lihe; Zhou, Demin; Xiao, Sulong published the artcile< Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes>, Application In Synthesis of 950846-89-6, the main research area is rhodamine fluorescent probe preparation pentacyclic triterpene antiviral influenza; Fluorescent probe; Influenza virus; Pentacyclic triterpene; Rhodamine B; Subcellular localization.

The antiviral activity of pentacyclic triterpenes has attracted increasing attention. However, the detailed antiviral mechanism remains fully unclear. In the present study, four C28 or C30 modified pentacyclic triterpene probes via conjugating with rhodamine B were designed and synthesized, and their anti-influenza virus activity was evaluated. The results indicated that two compounds 14 and 23 showed significant antiviral activity to influenza A/WSN/33 (H1N1) virus in Madin-Darby canine kidney (MDCK) cells with IC50 values of 8.36 and 8.24 μM, resp. The mechanism of action studies of representative probe 23 indicated that it could inhibit the membrane fusion by binding with influenza virus hemagglutinin (HA), and the apparent dissociation constant (KD) value for probe 23-HA interaction was successfully evaluated (1.78 x 10-5 M) using surface plasmon resonance spectroscopy. In addition, the subcellular localization of probe 23 in MDCK cells was determined by confocal microscopy and flow cytometry, and the results suggested that fluorescent probe 23 was rapidly taken up in MDCK cells and accumulated in cytoplasm, but no antiviral activity was observed after its entry into cells. The present study further confirmed our previous finding that pentacyclic triterpenes could tightly bind to the viral envelope HA protein, thus blocking the virus entry into host cells.

Shellaiah, Muthaiah’s team published research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020-12-05 | 950846-89-6

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetry. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Related Products of 950846-89-6.

Shellaiah, Muthaiah; Thirumalaivasan, Natesan; Aazaad, Basheer; Awasthi, Kamlesh; Sun, Kien Wen; Wu, Shu-Pao; Lin, Ming-Chang; Ohta, Nobuhiro published the artcile< Novel rhodamine probe for colorimetric and fluorescent detection of Fe3+ ions in aqueous media with cellular imaging>, Related Products of 950846-89-6, the main research area is rhodamine probe colorimetry fluorescent iron cell imaging; Colorimetric recognition; Fluorescent “turn-on”; Nanomolar detection; Photoinduced energy transfer; Reversible Fe(3+) sensor; Rhodamine-pyridine conjugate.

A novel rhodamine-pyridine conjugated spectroscopic probe RhP (I) was synthesized and its x-ray single crystalline properties were revealed with tabulation. The RhP displayed a distinct pale-pink colorimetric and “”turn-on”” fluorescent response to Fe3+ in aqueous media [H2O:DMSO (95:5, volume/volume)] than that of other interfering ions. During the Fe3+ recognition, the absorption (UV-visible) and photoluminescence (PL) spectral studies revealed new peaks at 561 and 592 nm, resp. The 1:1 stoichiometry and binding sites were verified by Job′s plot, ESI-mass, and 1H NMR titrations Subsequently, LOD and binding constant for RhP + Fe3+ complex were estimated as 102.3 nM and 6.265 × 104 M-1 from linear fitting and Benesi-Hildebrand plots, correspondingly. Sensor reversibility of RhP + Fe3+ by EDTA was demonstrated by UV/PL and TRPL studies. Moreover, the photoinduced energy transfer mechanism and band gap changes were established from the DFT interrogations. Lastly, cellular imaging studies were carried out to authenticate the real applicability of RhP in Fe3+ detection.

Song, Fan’s team published research in Dyes and Pigments in 2019-06-30 | 950846-89-6

Dyes and Pigments published new progress about Colorimetry. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Related Products of 950846-89-6.

Song, Fan; Yang, Chao; Shao, Xiaotao; Du, Lei; Zhu, Jing; Kan, Chun published the artcile< A reversible ""turn-off-on"" fluorescent probe for real-time visualization of mercury(II) in environmental samples and its biological applications>, Related Products of 950846-89-6, the main research area is reversible fluorescent probe visualization mercury environmental sample biol application.

In this study, we synthesized a novel fluorescent probe (S-TC) based on Thiooxo-Rhodamine B. In the design of the probe, we sulfided carbonyl groups of rhodamine spironolactam to thiocarbonyl groups. C=S functional group was used as a recognition group for Hg2+. S-TC has a good spectral response to Hg2+ in the EtOH/H2O solution (1:1, volume/volume) with low detection limits and high binding constants The detection limit and the association constant was calculated as 0.077 μM and 1.70 × 104 M-1, resp. S-TC displayed the traditional reversible “”turn-off-on”” fluorescence change with 1:1 binding stoichiometry. It is feasible to detect Hg2+ in real environmental water by S-TC. Biol. experiments demonstrated that S-TC can be used to detect to Hg2+ in living cells, animals and plant tissues.

Dyes and Pigments published new progress about Colorimetry. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Related Products of 950846-89-6.

Blackburn, Chester’s team published research in European Polymer Journal in 2019-11-30 | 950846-89-6

European Polymer Journal published new progress about Biological uptake. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Computed Properties of 950846-89-6.

Blackburn, Chester; Tai, Hongyun; Salerno, Martina; Wang, Xi; Hartsuiker, Edgar; Wang, Wenxin published the artcile< Folic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies>, Computed Properties of 950846-89-6, the main research area is folic acid rhodamine labeled hyperbranched polymer cell uptake pH.

Here, we report the synthesis of novel folated and fluorescent labeled pH responsive hyperbranched polymers (HBPs) via reversible addition fragmentation chain-transfer (RAFT) co-polymerization of 2-Pr acrylic acid (PAA), 2-(dimethylamino) Et methacrylate (DMAEMA) and disulfide diacrylate (DSDA) using 4-cyano-4-(((dodecylthio)carbonothioyl)thio)pentanoic acid (CDCTPA) as RAFT agent and post functionalization via bioconjugation techniques. The resultant HBPs were characterized by NMR Spectroscopy (NMR) and Size Exclusion Chromatog. (SEC). Dynamic Light Scattering (DLS) technique was used to measure the size changes of HPBs in solutions at different pH values to demonstrate pH responsiveness of the polymers. The cell uptake evaluations on these folated and fluorescent labeled HBPs were carried out using HeLa cell line and confirmed by confocal images. The results show that we have successfully synthesized the desired multifunctional hyperbranched poly (PAA-co-DMAEMA-co-DSDA) with a pH responsive characteristic and the potentials for use as a drug delivery vehicle.

Cao, Xiaorui’s team published research in Journal of Fluorescence in 2019-03-31 | 950846-89-6

Journal of Fluorescence published new progress about Biological imaging. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Synthetic Route of 950846-89-6.

Cao, Xiaorui; Zhang, Feifei; Bai, Yinjuan; Ding, Xiaohu; Sun, Wei published the artcile< A Highly Selective ""Turn-on"" Fluorescent Probe for Detection of Fe3+ in Cells>, Synthetic Route of 950846-89-6, the main research area is rhodamine fluorescent probe cell imaging iron detection; Cell imaging; DFT calculations; Fe3 +; Fluorescent probe; Rhodamine.

A new “”turn-on”” fluorescent probe Py based on rhodamine and piperonaldehyde was designed and synthesized for detecting Fe3+ in cells. The free probe Py was non-fluorescent. While only upon addition of Fe3+, the significant increase of the fluorescence and color were observed which could be visible directly by “”naked-eye””. The probe Py shows high selectivity and sensitivity for Fe3+ over other common metal ions in EtOH-H2O (3/2, volume/volume) mixed solution The association constant and the detection limit were calculated to be 4.81 x 104 M-1 and 1.18 x 10-8 mol/L resp. The introduction of piperonaldehyde unit could increase probe rigidity which could enhance its optical properties. Meanwhile, the binding mode between Py and Fe3+ was found to be a 1:1 complex formation. The d. functional theory (DFT) calculations were performed which would further confirm the recognition mechanism between probe Py and Fe3+. In addition, the probe has been proved to be reversible for detecting Fe3+. Moreover, the probe Py was used to detect Fe3+ in cells successfully.

Journal of Fluorescence published new progress about Biological imaging. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Synthetic Route of 950846-89-6.

Liu, Yuanyuan’s team published research in Journal of Chemical Research in 2020-07-31 | 950846-89-6

Journal of Chemical Research published new progress about Fluorescence. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application In Synthesis of 950846-89-6.

Liu, Yuanyuan; Li, Yi; Zong, Linghui; Zhang, Jingyi published the artcile< Comparison of two rhodamine-based polystyrene solid-phase fluorescent sensors for mercury(II) determination>, Application In Synthesis of 950846-89-6, the main research area is rhodamine based polystyrene microsphere fluorescent sensor mercury ion determination.

Two novel rhodamine-based polystyrene solid-phase fluorescent sensors PS-AC-I and PS-AC-II with different coordination atoms (O or S) are synthesized and shown to be able to detect Hg(II) ions. They are characterized by Fourier-transform IR spectroscopy and by SEM anal. Their fluorescent properties, including response time, pH effects, fluorescence titrations, metal ion competition and recycling, are investigated and compared. Sensor PS-AC-II displayed higher selectivity and sensitivity to Hg(II), with a lower detection limit of 0.032μM, which was 15 times better than PS-AC-I. A detection mechanism involving the Hg(II) chelation-induced ring-opening of the rhodamine spirolactam is proposed with the aid of theor. calculations

Adak, Arup Kumar’s team published research in ACS Omega in 2019-11-19 | 950846-89-6

ACS Omega published new progress about Fluorescence spectroscopy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Quality Control of 950846-89-6.

Adak, Arup Kumar; Dutta, Basudeb; Manna, Saikat Kumar; Sinha, Chittaranjan published the artcile< Rhodamine-Appended Benzophenone Probe for Trace Quantity Detection of Pd2+ in Living Cells>, Quality Control of 950846-89-6, the main research area is rhodamine benzophenone palladium living cell.

Designing a fluorogenic probe for the determination of Pd2+ is a challenging anal. task. Pd2+ is a potentially toxic and harmful substance even at a very low level of contamination in the end product. Herein, a promising spirolactam-functionalized chemosensor, rhodamine-appended benzophenone (HBR), is designed and characterized by spectroscopic (1H NMR, 13C NMR, ESI-MS, and FT-IR) data along with the single-crystal x-ray diffraction technique. It acts as a highly sensitive and selective fluorogenic chemosensor for Pd2+ ions over other environmentally relevant cations in aqueous ethanol (1:1, volume/volume) at pH 7.4. The limit of detection (LOD) is 34 nM that is far below the WHO recommended Pd uptake (47μM). The plausible mechanism involves the specific binding of HBR with Pd2+ and the formation of 1:1 stoichiometry of the complex, which has been supported by ESI-MS, FT-IR data, Job plot, and association constant data (Benesi-Hildebrand plot). The computation study has been attempted to explain the ring cleavage fluorescence enhancement scheme of HBR upon binding with Pd2+. Furthermore, this “”turn-on”” probe has successfully applied to image the Pd2+ ion in cultured MDA-MB-231 cells.

ACS Omega published new progress about Fluorescence spectroscopy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Quality Control of 950846-89-6.

Wang, Xiaodong’s team published research in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2020 | 950846-89-6

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Autophagy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Quality Control of 950846-89-6.

Wang, Xiaodong; Fan, Li; Wang, Yubin; Zhang, Caihong; Liang, Wenting; Shuang, Shaomin; Dong, Chuan published the artcile< Visual monitoring of the lysosomal pH changes during autophagy with a red-emission fluorescent probe>, Quality Control of 950846-89-6, the main research area is lysosome pH autophagy red emission fluorescent probe.

Autophagy plays crucial roles in maintaining normal intracellular homeostasis. Mol. probes capable of monitoring lysosomal pH changes during autophagy are still highly required yet challenging to develop. Here, a lysosome-targeting fluorescent pH probe, RML (I), is presented by introducing a methylcarbitol unit as the lysosome-targeting group to rhodamine B, which is highly sensitive to pH changes. RML exhibits remarkable pH-dependent behavior at 583 nm with a fluorescent enhancement of >148-fold. The pKa value is determined as 4.96, and the linear response with pH changes from 4.50-5.70, which is favorable for lysosomal pH imaging. Also RML diffuses selectively into lysosomes using confocal fluorescence microscopy. Using RML, the authors have successfully visualized autophagy by monitoring the lysosomal pH changes.