Synthesis of thiazolo[2′,3′:3,4][1,2,4]triazino[5,6-b]indole from 4,5-disubstituted isatin was written by Saha, Goutam Kumar;Rashid, M. D. Abdur;Islam, M. D. Rabiul. And the article was included in Journal of the Bangladesh Chemical Society in 2000.HPLC of Formula: 96187-75-6 This article mentions the following:
Condensation of 4,5-disubstituted isatin (I) with thiosemicarbazide yields the corresponding thiosemicarbazone, which on cyclization with 4% KOH solution gives 1,2,4-triazino[5,6-b]indole-3-thione derivative (II). Reaction of II with 1,2-dibromoethane in DMF affords the desired compound (III). In the experiment, the researchers used many compounds, for example, 6-Chloro-5-methylindoline-2,3-dione (cas: 96187-75-6HPLC of Formula: 96187-75-6).
6-Chloro-5-methylindoline-2,3-dione (cas: 96187-75-6) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 96187-75-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles