Category: 98-17-9

An article Cellulose as recyclable organocatalyst for ipso-hydroxylation of arylboronic acids WOS:000488141200007 published article about EFFICIENT HETEROGENEOUS CATALYST; OXIDATIVE HYDROXYLATION; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GREEN; NANOPARTICLES; METAL; MILD; CONVERSION; SOLVENTS in [Laskar, Khairujjaman; Paul, Subham; Bora, Utpal] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019, Cited 43. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign. (C) 2019 Elsevier Ltd. All rights reserved.

Category: indole-building-block. Welcome to talk about 98-17-9, If you have any questions, you can contact Laskar, K; Paul, S; Bora, U or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor WOS:000464108100012 published article about GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; NITRIC-OXIDE; ACTIVATION; PATHWAY; MACROPHAGES in [Elkamhawy, Ahmed; Roh, Eun Joo] KIST, Chem Kin Res Ctr, Seoul 02792, South Korea; [Elkamhawy, Ahmed] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Pharm, Med Chem Lab, Seoul 02447, South Korea; [Paik, Sora; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Fundamental Pharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Biochem, Seoul 02447, South Korea; [Roh, Eun Joo] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea in 2019, Cited 44. Product Details of 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

EGFR inhibitors are well-known as anticancer agents. Quite differently, we report our effort to develop EGFR inhibitors as anti-inflammatory agents. Pyrimidinamide EGFR inhibitors eliciting low micromolar IC50 and the structurally close non-EGFR inhibitor urea analog were synthesized. Comparing their nitric oxide (NO) production inhibitory activity in peritoneal macrophages and RAW 246.7 macrophages indicated that their anti-inflammatory activity in peritoneal macrophages might be a sequence of EGFR inhibition. Further evaluations proved that compound 4d significantly and dose-dependently inhibits LPS-induced iNOS expression and IL-1 beta, IL-6, and TNF-alpha production via NF-kappa B inactivation in peritoneal macrophages. Compound 4d might serve as a lead compound for development of a novel class of anti-inflammatory EGFR inhibitors.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Elkamhawy, A; Hassan, AHE; Paik, S; Lee, YS; Lee, HH; Shin, JS; Lee, KT; Roh, EJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. In 2019 TETRAHEDRON LETT published article about ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; HETEROGENEOUS CATALYST; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; ORGANIC FRAMEWORK; ROOM-TEMPERATURE; BOND-CLEAVAGE; PHENOLS; METAL in [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China; [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China; [Zhang, Yanbin; Guo, Hao] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Guo, Hao] Fudan Univ, Acad Engn & Technol, 220 Handan Rd, Shanghai 200433, Peoples R China; [Rios, Ramon] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England in 2019, Cited 52. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

We report herein a visible light-induced aerobic oxidative hydroxylation of boronic acids. The reaction employed 7H-benzo[c]thioxanthen-7-one as metal-free catalyst and dimethyl carbonate as green solvent. Scale-up experiment was achieved using 0.1 mol% catalyst in a good yield with column-free purification. This reaction showed great green chemistry features and potential in synthetic applications. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Ding, AS; Zhang, YB; Chen, Y; Rios, R; Hu, JH; Guo, H or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H5F3O. Mayer, RJ; Breugst, M; Hampel, N; Ofial, AR; Mayr, H in [Mayer, Robert J.; Breugst, Martin; Hampel, Nathalie; Ofial, Armin R.; Mayr, Herbert] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany; [Breugst, Martin] Univ Cologne, Dept Chem Organ Chem, Greinstr 4, D-50939 Cologne, Germany published Ambident Reactivity of Phenolate Anions Revisited: A Quantitative Approach to Phenolate Reactivities in 2019, Cited 86. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Prompted by the observation that the regioselectivities of phenolate reactions (C versus O attack) are opposite to the predictions by the principle of hard and soft acids and bases, we performed a comprehensive experimental and computational investigation of phenolate reactivities. Rate and equilibrium constants for the reactions of various phenolate ions with benzhydrylium ions (Aryl(2)CH(+)) and structurally related quinone methides have been determined photometrically in polar aprotic solvents. Quantum chemical calculations at the SMD(MeCN)/M06-2X/6-31+G(d,p) level confirmed that O attack is generally favored under kinetically controlled conditions, whereas C attack is favored under thermodynamically controlled conditions. Exceptions are diffusion limited reactions with strong electrophiles, which give mixtures of products arising from O and C attack, as well as reactions with metal alkoxides in nonpolar solvents, where oxygen attack is blocked by strong ion pairing. The Lewis basicity (LB) and nucleophilicity (N, s(N)) parameters of phenolates determined in this work can be used to predict whether their reactions with electrophiles are kinetically or thermodynamically controlled and whether the rates are activation-or diffusion-limited. Comparison of the measured rate constants for the reactions of phenolates with carbocations with the Gibbs energies for single electron transfer manifests that these reactions proceed via polar mechanisms.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Mayer, RJ; Breugst, M; Hampel, N; Ofial, AR; Mayr, H or concate me.. HPLC of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H5F3O. Authors Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I in WILEY-V C H VERLAG GMBH published article about in [Kutt, Agnes; Tshepelevitsh, Sofja; Saame, Jaan; Lokov, Mart; Kaljurand, Ivari; Selberg, Sigrid; Leito, Ivo] Univ Tartu, Inst Chem, Ravila 14a, EE-50411 Tartu, Estonia in 2021, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The equilibrium acidity scale (pK(a) scale) in acetonitrile has been supplemented by numerous new compounds and new Delta pK(a) measurements. It now contains altogether 231 acids – over twice more than published previously – linked by 569 Delta pK(a) measurements and spans between the pK(a) values of hydrogen iodide (2.8) and indole (32.57), covering close to 30 orders of magnitude. Measurement results acquired over the last 15 years were added to the scale and new least-squares treatment was carried out. The treatment yielded revised pK(a) values for the compounds published previously, with the root mean square difference between revised and previous values 0.04, demonstrating very good stability of the scale. Correlation equations were developed for estimating pK(a) values for the studied types of compounds in water, DMSO, DMF, and 1,2-dichloroethane on the basis of pK(a) values in acetonitrile. These equations enable predicting pK(a) values with an average error around or less than 1 pK(a) unit, which is a sufficient accuracy for many applications. The scale is expected to be a useful tool for the widest possible research areas in organic chemistry, electrochemical power sources, catalysis, etc.

Welcome to talk about 98-17-9, If you have any questions, you can contact Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I or send Email.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H5F3O. Authors Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I in WILEY-V C H VERLAG GMBH published article about in [Kutt, Agnes; Tshepelevitsh, Sofja; Saame, Jaan; Lokov, Mart; Kaljurand, Ivari; Selberg, Sigrid; Leito, Ivo] Univ Tartu, Inst Chem, Ravila 14a, EE-50411 Tartu, Estonia in 2021, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The equilibrium acidity scale (pK(a) scale) in acetonitrile has been supplemented by numerous new compounds and new Delta pK(a) measurements. It now contains altogether 231 acids – over twice more than published previously – linked by 569 Delta pK(a) measurements and spans between the pK(a) values of hydrogen iodide (2.8) and indole (32.57), covering close to 30 orders of magnitude. Measurement results acquired over the last 15 years were added to the scale and new least-squares treatment was carried out. The treatment yielded revised pK(a) values for the compounds published previously, with the root mean square difference between revised and previous values 0.04, demonstrating very good stability of the scale. Correlation equations were developed for estimating pK(a) values for the studied types of compounds in water, DMSO, DMF, and 1,2-dichloroethane on the basis of pK(a) values in acetonitrile. These equations enable predicting pK(a) values with an average error around or less than 1 pK(a) unit, which is a sufficient accuracy for many applications. The scale is expected to be a useful tool for the widest possible research areas in organic chemistry, electrochemical power sources, catalysis, etc.

Welcome to talk about 98-17-9, If you have any questions, you can contact Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I or send Email.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Visible light induced oxidative hydroxylation of boronic acids WOS:000459950000004 published article about ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; HETEROGENEOUS CATALYST; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; ORGANIC FRAMEWORK; ROOM-TEMPERATURE; BOND-CLEAVAGE; PHENOLS; METAL in [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China; [Ding, Aishun; Chen, Yang; Hu, Jianhua] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China; [Zhang, Yanbin; Guo, Hao] Fudan Univ, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Guo, Hao] Fudan Univ, Acad Engn & Technol, 220 Handan Rd, Shanghai 200433, Peoples R China; [Rios, Ramon] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England in 2019, Cited 52. Computed Properties of C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

We report herein a visible light-induced aerobic oxidative hydroxylation of boronic acids. The reaction employed 7H-benzo[c]thioxanthen-7-one as metal-free catalyst and dimethyl carbonate as green solvent. Scale-up experiment was achieved using 0.1 mol% catalyst in a good yield with column-free purification. This reaction showed great green chemistry features and potential in synthetic applications. (C) 2019 Elsevier Ltd. All rights reserved.

Computed Properties of C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ding, AS; Zhang, YB; Chen, Y; Rios, R; Hu, JH; Guo, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Laskar, K; Paul, S; Bora, U in PERGAMON-ELSEVIER SCIENCE LTD published article about EFFICIENT HETEROGENEOUS CATALYST; OXIDATIVE HYDROXYLATION; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GREEN; NANOPARTICLES; METAL; MILD; CONVERSION; SOLVENTS in [Laskar, Khairujjaman; Paul, Subham; Bora, Utpal] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019, Cited 43. Recommanded Product: 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laskar, K; Paul, S; Bora, U or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-(Trifluoromethyl)phenol. In 2021 ANGEW CHEM INT EDIT published article about ASYMMETRIC CATALYSIS; BINOL; DERIVATIVES; 2-NAPHTHOL; ACTIVATION; LIGANDS; ACID in [Zhao, Xiao-Jing; Li, Zi-Hao; Ding, Tong-Mei; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Ai-Fang; Xie, Yu-Yang] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2021, Cited 70. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel Cu-I/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3 ‘-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the pi-pi stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

Safety of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Zhao, XJ; Li, ZH; Ding, TM; Tian, JM; Tu, YQ; Wang, AF; Xie, YY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H5F3O. Recently I am researching about METAL-FREE; STEREOSELECTIVE-SYNTHESIS; ALKENE DERIVATIVES; ACTIVATED ALKYNES; CYCLIZATION; MIGRATION; ACIDS; DIFUNCTIONALIZATION; COUMARINS; BOND, Saw an article supported by the DST-SERB India; UGCUniversity Grants Commission, India; IIT-Madras. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

An oxidative trifunctionalization of aryl alkynoates has been devised via the chalcogenide radical triggered intramolecular 1,4-aryl migration/decarboxylation cascade to prepare 1,1-dichalcogenide tetrasubstituted alkenes in high yields (up to 98 %). This operationally simple reaction proceeds under metal-free conditions, can be executed on gram scale, and highlights formal 1,1-difunctionalization of alkynes. Synthetic potential of this protocol was demonstrated through a twofold cascade rearrangement to access highly conjugated tetra-selenylated alkenes along with a cross-dehydrogenative annulation to prepare fluorene derivative.

Welcome to talk about 98-17-9, If you have any questions, you can contact Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M or send Email.. Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles