Category: 98600-34-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98600-34-1,4-Bromoindole-3-carboxyaldehyde,as a common compound, the synthetic route is as follows.

-Acetyl-4-bromo-l,2-dihydro-indol-3-one: 4-Bromo-lH-indole-3-carbaldehyde (4.0 g, 17.8 mmol) was stirred in acetic anhydride (20 mL) at reflux for 4h. The reaction was cooled and concentrated in vacuo. Cold MeOH was added to precipitate a white solid, whi, 98600-34-1

98600-34-1 4-Bromoindole-3-carboxyaldehyde 2763178, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/129401; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98600-34-1,4-Bromoindole-3-carboxyaldehyde,as a common compound, the synthetic route is as follows.

Example 43 N4-(5-Cyclopropyl- 1 H-pyrazol-3 -yl)-N2-((3 -methyl- 1 H-indol-4-yl)methyl)pyrimidine-2,4-diamine (1-92) step 1 : To a refluxing solution of 4-bromo-lH-indole-3-carbaldehyde (644 mg, 2.87 mmol) in dry THF (20 mL) was added LiAlH4 (218 mg, 5.75 mmol) in several small portions. Heating at reflux was continued for 1 h, the reaction cooled to RT and quenched with water (220 mu?^), 15 % aq. NaOH (w/w, 220 mu? ), and water (650 mu?^). The resulting precipitate was filtered and the filtrate was concentrated under reduced pressure to dryness. To the residue was added aq. NaOH (10 mL) and the solution twice extracted with DCM (2 x 10 mL). The combined extracts were dried (MgSO i), filtered and concentrated in vacuo to afford 454 mg (75%) of 4-bromo-3 -methyl- lH-indole (230) as light brown oil: MS (ESI) m/z = 210.1 [M+l] +, 98600-34-1

As the paragraph descriping shows that 98600-34-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WO2013/26914; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles