98623-50-8, 2-(1H-Indol-5-yl)-N-methylethanesulfonamide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,98623-50-8
A solution of 2-(1H-Indol-5-yl)-ethanesulfonic acidmethylamide (1) (3 g, 0.013 mol) in tetrahydrofuran (30 ml)was cooled to -70 to -80oC and then 2M solution of n-BuLi(0.2 g, 0.0031 mol) in THF (1.56 ml) was added drop wise atsame temperature and stirred for 30 minutes at -70 to -80oCfollowed by addition of methyl iodide (7.1 g, 0.05 mol). Theprogress of the reaction was monitored by TLC (mobilephase 8:2 ethyl acetate: hexane). After completion of thereaction, the reaction mass was quenched with isopropylalcohol and the solvent was distilled out under vacuum. Theresidue was taken in water and the compound was extractedwith ethyl acetate. The organic layer was dried over sodiumsulphate and distilled under vacuum at 50oC to give 2-(3-Methyl-1H-indol-5-yl)-ethanesulfonic acid methylamide (17)as white solid. Yield: 2.5 g (76%). Molecular formula:C12H16N2O2S; Calc. C, 57.14; H, 6.35; N, 11.11. Found: C,57.10; H, 6.30; N, 11.00. IR(KBr, numax, cm-1): 3415( -NH strof indole), 3989(-NH str of sulfonamide), 3050(aromatic -CH str.), 2953(aliphatic -CH str), 1517(-C=C str); 1HNMR(400 MHz, delta ppm, CDCl3): 2.67(d, 3H, J = 5.24 Hz,C12-H), 3.16-3.20(m, 2H, C10-H), 3.29-3.33(m, 2H, C11-H),3.75(s, 3H, C13-H), 4.20(q, 1H, NH of amide), 6.42(d, 1H, J= 3.4 Hz, ArC6-H), 7.04-7.07(m, 2H, ArC4-H & C2-H),7.23-7.27(m, 1H, ArC7-H ), 7.45-(s, 1H, NH protons of indole);13C NMR (400 MHz, delta ppm, CDCl3):29.38(C-12),30.08(C-10), 32.95 (C-13),52.72(C-11),100.67 (C-3), 109.72(C-6),120.29(C-7), 121.99(C-4), 128.56(C-2), 128.86(C-8),129.64(C-9), 135.79 (C-5); MS (m/z): 253.
The synthetic route of 98623-50-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Behera, Ajaya Kumar; Majumdar, Poulomi; Mohanta, Prajna Parimita; Mishra, Sushanta Kumar; Letters in Organic Chemistry; vol. 15; 4; (2018); p. 265 – 269;,
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