Category: 99-93-4

Application In Synthesis of 4′-Hydroxyacetophenone. Eltoukhy, A; Jia, Y; Nahurira, R; Abo-Kadoum, MA; Khokhar, I; Wang, JH; Yan, YC in [Eltoukhy, Adel; Jia, Yang; Nahurira, Ruth; Khokhar, Ibatsam; Wang, Junhuan; Yan, Yanchun] Chinese Acad Agr Sci, Grad Sch, Beijing 100081, Peoples R China; [Eltoukhy, Adel; Abo-Kadoum, M. A.] Al Azhar Univ, Dept Bot & Microbiol, Fac Sci, Assiut 71524, Egypt; [Abo-Kadoum, M. A.] Southwest Univ, Inst Modern Biopharmaceut, Sch Life Sci, Chongqing 400715, Peoples R China published Biodegradation of endocrine disruptor Bisphenol A by Pseudomonas putida strain YC-AE1 isolated from polluted soil, Guangdong, China in 2020.0, Cited 55.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Background Bisphenol A is an important organic chemical as an intermediate, final and inert ingredient in manufacturing of many important products like polycarbonate plastics, epoxy resins, flame retardants, food-drink packaging coating, and other. BPA is an endocrine disruptor compound that mimics the function of estrogen causing damage to reproductive organs. Bacterial degradation has been consider as a cost effective and eco-friendly method for BPA degradation compared with physical and chemical methods. This study aimed to isolate and identify bacterial strain capable to degrade and tolerate high concentrations of this pollutant, studying the factors affecting the degradation process and study the degradation mechanism of this strain. Results YC-AE1 is a Gram negative bacterial strain isolated from soil and identified as Pseudomonas putida by 16S rRNA gene sequence and BIOLOG identification system. This strain found to have a high capacity to degrade the endocrine disruptor Bisphenol A (BPA). Response surface methodology using central composite design was used to statistically optimize the environmental factors during BPA degradation and the results obtained by significant model were 7.2, 30 degrees C and 2.5% for optimum initial pH, temperature and inoculum size, respectively. Prolonged incubation period with low NaCl concentration improve the biodegradation of BPA. Analysis of variance (ANOVA) showed high coefficient of determination, R-2 and Adj-R-2 which were 0.9979 and 0.9935, respectively. Substrate analysis found that, strain YC-AE1 could degrade a wide variety of bisphenol A-related pollutants such as bisphenol B, bisphenol F, bisphenol S, Dibutyl phthalate, Diethylhexyl phthalate and Diethyl phthalate in varying proportion. Pseudomonas putida YC-AE1 showed high ability to degrade a wide range of BPA concentrations (0.5-1000 mg l(- 1)) with completely degradation for 500 mg l(- 1) within 72 h. Metabolic intermediates detected in this study by HPLC-MS were identified as 4,4-dihydroxy-alpha-methylstilbene, p-hydroxybenzaldeyde, p-hydroxyacetophenone, 4-hydroxyphenylacetate, 4-hydroxyphenacyl alcohol, 2,2-bis(4-hydroxyphenyl)-1-propanol, 1,2-bis(4-hydroxyphenyl)-2-propanol and 2,2-bis(4-hydroxyphenyl) propanoate. Conclusions This study reports Pseudomonas putida YC-AE1 as BPA biodegrader with high performance in degradation and tolerance to high BPA concentration. It exhibited strong degradation capacity and prominent adaptability towards a wide range of environmental conditions. Moreover, it degrades BPA in a short time via two different degradation pathways.

Welcome to talk about 99-93-4, If you have any questions, you can contact Eltoukhy, A; Jia, Y; Nahurira, R; Abo-Kadoum, MA; Khokhar, I; Wang, JH; Yan, YC or send Email.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 GREEN CHEM published article about AEROBIC OXIDATIVE HYDROXYLATION; HIGHLY EFFICIENT CONVERSION; ARYL BORONIC ACIDS; IPSO-HYDROXYLATION; VISIBLE-LIGHT; CATALYZED HYDROXYLATION; PHOTOREDOX CATALYSIS; PHENOLS; MILD; GENERATION in [Xu, Yu-Ting; Li, Chen-Yuan; Huang, Xiao-Bo; Gao, Wen-Xia; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China in 2019, Cited 46. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Photoinduced hydroxylation of boronic acids with molecular oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcohols in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility.

Safety of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Xu, YT; Li, CY; Huang, XB; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Investigating Lignin-Derived Monomers and Oligomers in Low-Molecular-Weight Fractions Separated from Depolymerized Black Liquor Retentate by Membrane Filtration WOS:000655084000001 published article about BASE-CATALYZED DEPOLYMERIZATION; TANDEM MASS-SPECTROMETRY; CHROMATOGRAPHY; FRAGMENTATION; VALORIZATION; OXIDATION in [Li, Kena; Blomberg, Sara; Hulteberg, Christian] Lund Univ, Dept Chem Engn, SE-21100 Lund, Sweden; [Prothmann, Jens; Sandahl, Margareta; Turner, Charlotta] Lund Univ, Ctr Anal & Synth, Dept Chem, SE-22100 Lund, Sweden in 2021.0, Cited 38.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Category: indole-building-block

Base-catalyzed depolymerization of black liquor retentate (BLR) from the kraft pulping process, followed by ultrafiltration, has been suggested as a means of obtaining low-molecular-weight (LMW) compounds. The chemical complexity of BLR, which consists of a mixture of softwood and hardwood lignin that has undergone several kinds of treatment, leads to a complex mixture of LMW compounds, making the separation of components for the formation of value-added chemicals more difficult. Identifying the phenolic compounds in the LMW fractions obtained under different depolymerization conditions is essential for the upgrading process. In this study, a state-of-the-art nontargeted analysis method using ultra-high-performance supercritical fluid chromatography coupled to high-resolution multiple-stage tandem mass spectrometry (UHPSFC/HRMSn) combined with a Kendrick mass defect-based classification model was applied to analyze the monomers and oligomers in the LMW fractions separated from BLR samples depolymerized at 170-210 degrees C. The most common phenolic compound types were dimers, followed by monomers. A second round of depolymerization yielded low amounts of monomers and dimers, while a high number of trimers were formed, thought to be the result of repolymerization.

Category: indole-building-block. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2020.0 BIOORGAN MED CHEM published article about ALZHEIMERS-DISEASE; STEREOSELECTIVE INHIBITION; BAMBUTEROL; CHOLINESTERASES; DEMENTIA; KINETICS; UPDATE in [Wu, Jie] Jinan Univ, Sch Pharm, Guangzhou 510632, Peoples R China; [Wu, Jie] YZ Hlth Tech Inc, Zhuhai 519000, Peoples R China; [Pistolozzi, Marco] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China; [Liu, Siyu; Tan, Wen] Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China; [Tan, Wen] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Bandar Sunway 47500, Selangor Darul, Malaysia in 2020.0, Cited 33.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), has been approved by U.S. Food and Drug Administration to treat Alzheimer’s disease (AD) and Parkinson’s disease (PD) dementia. In the current work, a bambuterol derivative lacking one of the carbamoyloxy groups on the benzene ring (BMC-1) and its analogues were synthesized using 1-(3-hydroxyphenyl) ethan-1-one and 1-(4-hydroxyphenyl) ethan-1-one as starting materials. In-vitro cholinesterase assay established that nine compounds were more potent to inhibit both electric eel AChE and equine serum BChE than rivastigmine under the same experimental conditions. Further study confirmed that among the nine carbamates, BMC-3 (IC50(AChE) = 792 nM, IC50(BChE) = 2.2 nM) and BMC-16 (IC50(AChE) = 266 nM, IC50(BChE) = 10.6 nM) were excellent cholinesterase inhibitors with potential of permeating through the blood-brain barrier. These carbamates could be used as potential dual inhibitors of AChE and BChE and to discover novel drugs for the treatment of AD and PD dementia.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wu, J; Pistolozzi, M; Liu, SY; Tan, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about VISCERAL LEISHMANIASIS; IN-VITRO; 2-SUBSTITUTED QUINOLINES; BIOLOGICAL EVALUATION; ANTIMALARIAL; CHEMOTHERAPY; DERIVATIVES; COMPLEXES; DISCOVERY; EFFICACY, Saw an article supported by the . Safety of 4′-Hydroxyacetophenone. Published in HINDAWI LTD in LONDON ,Authors: Abdelwahid, MAS; Elsaman, T; Mohamed, MS; Latif, SA; Mukhtar, MM; Mohamed, MA. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Leishmaniasis is a fatal neglected parasitic disease caused by protozoa of the genus Leishmania and transmitted to humans by different species of phlebotomine sandflies. The disease incidence continues to increase due to lack of vaccines and prophylactic drugs. Drugs commonly used for the treatment are frequently toxic and highly expensive. The problem of these drugs is further complicated by the development of resistance. Thus, there is an urgent need to develop new antileishmanial drug candidates. The aim of this study was to synthesize certain quinoline-4-carboxylic acids, confirm their chemical structures, and evaluate their antileishmanial activity. Pfitzinger reaction was employed to synthesize fifteen quinoline-4-carboxylic acids (Q1-Q15) by reacting equimolar mixtures of isatin derivatives and appropriate -methyl ketone. The products were purified, and their respective chemical structures were deduced using various spectral tools (IR, MS, H-1 NMR, and C-13 NMR). Then, they were investigated against L. donovani promastigote (clinical isolate) in different concentration levels (200g/mL to 1.56g/mL) against sodium stibogluconate and amphotericin B as positive controls. The IC50 for each compound was determined and manipulated statistically. Among these compounds, Q1 (2-methylquinoline-4-carboxylic acid) was found to be the most active in terms of IC50.

Safety of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Abdelwahid, MAS; Elsaman, T; Mohamed, MS; Latif, SA; Mukhtar, MM; Mohamed, MA or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4′-Hydroxyacetophenone. Jeong, J; Kim, KH; Kim, DY; Chandrasekaran, G; Kim, M; Pagire, SH; Dighe, M; Choi, EY; Bak, SM; Kim, EY; Shin, MG; Choi, SY; Ahn, JH in [Jeong, Jieun; Kim, Minhee; Pagire, Suvarna H.; Dighe, Mahesh; Ahn, Jin Hee] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; [Kim, Kun-Hee; Chandrasekaran, Gopalakrishnan; Choi, Seok-Yong] Chonnam Natl Univ, Dept Biomed Sci, Med Sch, Gwangju, South Korea; [Kim, Dong-Young] Univ Ulsan, Coll Med, Dept Biomed Sci, Seoul, South Korea; [Bak, Su-Min; Kim, Eun-Young] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea; [Bak, Su-Min; Kim, Eun-Young] Kyung Hee Univ, Dept Biol, Seoul, South Korea; [Shin, Myung-Geun] Chonnam Natl Univ, Dept Lab Med, Med Sch, Gwangju, South Korea published Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model in 2019.0, Cited 18.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A new series of 1,3-diketone, heterocyclic and alpha, beta-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jeong, J; Kim, KH; Kim, DY; Chandrasekaran, G; Kim, M; Pagire, SH; Dighe, M; Choi, EY; Bak, SM; Kim, EY; Shin, MG; Choi, SY; Ahn, JH or concate me.. Recommanded Product: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 CHEM-EUR J published article about NITROGEN-CONTAINING BISPHOSPHONATES; PALLADIUM-CATALYZED PHOSPHONATION; PD(II)-CATALYZED PHOSPHORYLATION; REGIOSELECTIVE PHOSPHONATION; BIOLOGICAL EVALUATION; DIPHOSPHATE SYNTHASE; H-PHOSPHONATES; DRUG-DELIVERY; BONE; ALKYNES in [Cao Hao-Qiang; Liu Hao-Nan; Liu Zhe-Yuan; Qiao Bao-Kun; Zhang Fa-Guang; Ma Jun-An] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China; [Cao Hao-Qiang; Liu Hao-Nan; Liu Zhe-Yuan; Qiao Bao-Kun; Zhang Fa-Guang; Ma Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China; [Zhang Fa-Guang; Ma Jun-An] Tianjin Univ, Joint Sch NUS & TJU, Int Campus, Fuzhou 350207, Peoples R China in 2020.0, Cited 120.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means of proton-coupled electron-transfer (PCET)-triggered enamido C(sp(2))-H diphosphorylation. This reaction represents a rare example of realizing the challenging double C-P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET-initiated radical relay process.

Safety of 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4′-Hydroxyacetophenone. Dulac, M; Nagarathinam, C; Dansette, P; Mansuy, D; Boucher, JL in [Dulac, Martin; Nagarathinam, Citra; Dansette, Patrick; Mansuy, Daniel; Boucher, Jean-Luc] Univ Paris 05, CNRS, UMR 8601, Lab Chim & Biochim Pharmacol & Toxicol, 45 Rue St Peres, F-75006 Paris, France published Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes in 2019.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The drug anetholedithiolethione (ADT) and its analogs have been extensively used as H2S donors. However, the mechanism of H2S formation from ADT under biologic conditions remains almost completely unknown. This article shows that only small amounts of H2S are formed during incubation of ADT and of its metabolite anetholedithiolone (ADO) with rat liver cytosol or with rat liver microsomes (RLM) in the absence of NADPH, indicating that H2S formation under these conditions is of hydrolytic origin only to a minor extent. By contrast, much greater amounts of H2S are formed upon incubation of ADT and ADO with RLM in the presence of NADPH and dioxygen, with a concomitant formation of H2S and para-methoxy-acetophenone (pMA). Moreover, H2S and pMA formation under those conditions are greatly inhibited in the presence of N-benzyl-imidazole indicating the involvement of cytochrome P450-dependent monooxygenases. Mechanistic studies show the intermediate formation of the ADT-derived 1,2-dithiolium cation and of the ADO sulfoxide during microsomal metabolism of ADT and ADO, respectively. This article proposes the first detailed mechanisms for the formation of H2S from microsomal metabolism of ADT and ADO in agreement with those data and with previously published data on the metabolism of compounds involving a C=S bond. Finally, this article shows for the first time that ADO is a better H2S donor than ADT under those conditions. SIGNIFICANCE STATEMENT Incubation of anetholedithiolethione (ADT) or its metabolite anetholedithiolone (ADO) in the presence of rat liver microsomes, NADPH, and O-2 leads to H2S. This article shows for the first time that this H2S formation involves several steps catalyzed by microsomal monooxygenases and that ADO is a better H2S donor than ADT. We propose the first detailed mechanisms for the formation of H2S from the microsomal metabolism of ADT and ADO.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles WOS:000460577700005 published article about PRENYLATED ISOFLAVONOIDS; NATURAL ISOFLAVONOIDS; MEDICINAL CHEMISTRY; FLUORINE; DERIVATIVES; DISCOVERY; DESIGN; INHIBITORS; BIOISOSTERES; LIGANDS in [Izquierdo, Javier; Jain, Atul D.; Schiltz, Gary E.] Northwestern Univ, Ctr Mol Innovat & Drug Discovery, Evanston, IL 60208 USA; [Abdulkadir, Sarki A.] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA; [Abdulkadir, Sarki A.; Schiltz, Gary E.] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA; [Schiltz, Gary E.] Northwestern Univ, Dept Pharmacol, Chicago, IL 60611 USA in 2019.0, Cited 75.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF (3) ), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Izquierdo, J; Jain, AD; Abdulkadir, SA; Schiltz, GE or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4′-Hydroxyacetophenone. Authors Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS in WILEY published article about in [Telu, Jhonsee Rani; Kuntala, Naveen; Anireddy, Jaya Shree] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, Inst Sci & Technol, Hyderabad 500085, India; [Kankanala, Kavitha; Pal, Sarbani] MNR Degree & PG Coll, Dept Chem, Hyderabad, India; [Banothu, Venkanna] JNTUH, IST, Ctr Biotechnol, Hyderabad, India in 2021.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We describe the synthesis, characterization, and in vitro antibacterial evaluation of a library of novel compounds based on 1,2,3-triazolo phosphonate framework along with the evaluation of DNA gyrase inhibitory potential of a promising molecule in silico. Preparation of these compounds was carried out via a multistep sequence comprising of the Abramov reaction followed by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key steps. Various alpha-hydroxyphosphonate derivatives containing either a secondary or tertiary alcohol at the alpha position were prepared. When screened for their antibacterial activities in vitro using a Gram-positive (Staphylococcus aureus) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) strains, majority of these derivatives exhibited reasonable to good effects with the analogue 5k being active against all the strains. The SAR analysis indicated that the activity was influenced by the position of the alpha-hydroxyphosphonate moiety as well as the substituent present on the benzene ring attached to the 1,2,3-triazole ring. Moreover, the compound 5k showed strong interactions with the DNA active site when docked into the DNA gyrase in silico. Thus, the 1,2,3-triazolo phosphonate derivative 5k appeared to be a novel and promising hit molecule that deserves further study as a potential antibacterial agent.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles