Category: 99-93-4

Espinoza-Hicks, JC; Chacon-Vargas, KF; Hernandez-Rivera, JL; Nogueda-Torres, B; Tamariz, J; Sanchez-Torres, LE; Camacho-Davila, A in [Espinoza-Hicks, Jose C.; Hernandez-Rivera, Jessica L.; Camacho-Davila, Alejandro] Univ Autonoma Chihuahua, Fac Ciencias Quim, Campus Univ,Apartado Postal 669, Chihuahua, Chih, Mexico; [Fabiola Chacon-Vargas, Karla; Enid Sanchez-Torres, Luvia] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Inmunol, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico; [Fabiola Chacon-Vargas, Karla; Nogueda-Torres, Benjamin] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Parasitol, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico; [Tamariz, Joaquin] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Quim Organ, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico published Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation in 2019.0, Cited 43.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Each substituent was attached to the A ring in some compounds and to the B ring in others, with additional substituents placed on the chalcone moiety. The present aim was to evaluate the effect of the substitution pattern on leishmanicidal and trypanocidal activity. When tested at a single concentration, the compounds exerting a metabolic inhibition close to or exceeding 50% for Leishmania mexicana were 11, 17 and 12, and for Trypanosoma cruzi were 11, 17, 15 and 26. Upon determining the selectivity index (SI =IC50/CC50), the values were 80.9, 1.24 and 55.12 for 11, 17 and 12 (respectively) versus L mexicana, and 75.1, 1.43, 27.36 and 33.52 for 11, 17, 15 and 26 (respectively) versus T. cruzi. Structural isomers 11 and 17 showed activity for both the L mexicana and T. cruzi strains, though the greater cytotoxic activity of 17 led to a lower SI. Compounds 12, 15 and 26 were species specific. For I cruzi, the SI was higher for 11, 15 and 26 than for the reference drugs nifurtimox and benznidazole. The examination of promastigote morphology after exposing L mexicana and T. cruzi to 11 revealed a decrease in cell density. The current findings suggest that 11 could be a useful lead compound for further SAR studies. (C) 2019 Elsevier Masson SAS. All rights reserved.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Espinoza-Hicks, JC; Chacon-Vargas, KF; Hernandez-Rivera, JL; Nogueda-Torres, B; Tamariz, J; Sanchez-Torres, LE; Camacho-Davila, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media WOS:000579422600014 published article about KETOXIMES; LACTAMS; REAGENT; OXIME; MILD in [Verma, Saumya; Kumar, Puneet; Chandra, Dinesh; Yadav, Ajay K.; Jat, Jawahar L.] Babasaheb Bhimrao Ambedkar Univ Cent Univ, Dept Chem, Lucknow, Uttar Pradesh, India; [Khatana, Anil K.; Tiwari, Bhoopendra] Ctr Biomed Res, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow, Uttar Pradesh, India in 2020.0, Cited 56.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A zinc(II)-catalyzed single-step protocol for the Beckmann rearrangement using hydroxylamine-O-sulfonic acid (HOSA) as the nitrogen source in water was developed. This direct method efficiently produces secondary amides under open atmosphere in a pure form after basic aqueous workup. It is environmentally benign and operationally simple.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, S; Kumar, P; Khatana, AK; Chandra, D; Yadav, AK; Tiwari, B; Jat, JL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about NATURAL-PRODUCTS; MEROTERPENOIDS; DERIVATIVES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773602, 41906106]; Guangdong Provincial Special Fund for Marine Economic Development Project [[2020]042]; Guangdong Special Support Program [2019TQ05Y375]; Innovation Promotion Association of CAS [2020342]; Team Project of the Natural Science Foundation of Guangdong Province [2016A030312014]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Liu, HX; Chen, SC; Zhang, X; Dong, CM; Chen, YC; Liu, ZM; Tan, HB; Zhang, WM. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Formula: C8H8O2

A highly substituted phenol derivative, effphenol A (1), was isolated from the deep-sea-derived fungus Trichobotrys effuse FS524. Its complete structural assignment was established through a combination of spectroscopic analysis together with single-crystal X-ray diffraction experiments and further unequivocally confirmed by a biomimetic total synthesis. Structurally, effphenol A possesses a poly-substituted 6-5/6/6 tetracyclic ring system, which represents the first case of such a skeleton found in nature. Furthermore, the cytotoxic activity of effphenol A (1) toward four human cancer cell lines was assayed.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Liu, HX; Chen, SC; Zhang, X; Dong, CM; Chen, YC; Liu, ZM; Tan, HB; Zhang, WM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BACTERIAL LEAF-BLIGHT; ORYZAE PV. ORYZAE; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; MOLECULAR DOCKING; RESISTANCE GENES; DESIGN; ANTICANCER; HYBRIDS; CYTOTOXICITY, Saw an article supported by the National Key Research and Development Program of China [2017YFD0200506]; Science and Technology Project of Guizhou Province [20185781]. SDS of cas: 99-93-4. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by H-1-NMR, C-13-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 11.4 mu g mL(-1), which is significantly superior to those of bismerthiazol (BT) (51.6 mu g mL(-1)) and thiodiazole-copper (TC) (94.7 mu g mL(-1)). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with an EC50 value of 44.3 mu g mL(-1), which was superior to that of ningnanmycin (120.6 mu g mL(-1)). Microscale thermophoresis (MST) also showed that the binding of compounds 2e and 2h to Tobacco mosaic virus coat protein (TMV-CP) yielded K-d values of 0.270 and 0.301 mu mol L-1, which are better than that of ningnanmycin (0.596 mu mol L-1). At the same time, molecular docking studies for 2e and 2h with TMV-CP (PDB code: ; 1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP in each case. These results suggested that chalcone derivatives containing a thiophene sulfonate group may be considered as activators in the design of antibacterial and antiviral agents.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W or concate me.. SDS of cas: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 J FOOD SCI published article about TONGUE; NOSE in [Kim, Da-som; Lee, Jookyeong Tracy; Hong, Seong Jun; Cho, Jin-Ju; Shin, Eui-Cheol] Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 52725, South Korea in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

This study aims to investigate alterations in volatile compounds and chemical components that may affect the sensory properties of Cynanchi wilfordii roasted at 120 degrees C and 180 degrees C for various durations of time (0 to 4 min). For volatile compound profiles, tridecane, tetradecane, and ethyl hexyl ether were detected as major compounds of the sample without roasting. As the roasting temperature increased, the types of volatile compounds increased, whereas the content decreased with an increase in heterocyclic compound generation. The sample roasted at 120 degrees C for 1 min showed a notably different profile pattern from the other roasted samples. For the sniffing test performed by trained panelists using gas chromatography olfactometry, naphthalene and nonanal, which induce spicy and raw C. wilfordii, respectively, were perceived most intensely throughout all the samples. In the electronic tongue analysis, the sample roasting at 180 degrees C showed an increased and decreased pattern in umami taste and saltiness, respectively, with increased roasting time. Electronic tongue analysis results showed that the sample roasted at 180 degrees C for 4 min would have the best sensory preference. Along with the volatile compound profiles, the sample roasted at 120 degrees C for 1 min had more sourness than the other samples, and would potentially have distinctive sensory characteristics. This study should provide baseline data on variations in the sensory properties and industrial applications of C. wilfordii upon roasting. Practical Application Various applications of food ingredients through changes in sensory characteristics by roasting will provide consumers more options for food selections. Accordingly, this study will be utilized by (1) individuals and food companies who are interested in functional foods, (2) individuals and food industries that seek optimum roasting conditions for proper sensory characteristics of foods, and (3) farmers and crop producers who seek for utilization the applications of Cynanchi wilfordii as a food ingredient.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kim, DS; Lee, JT; Hong, SJ; Cho, JJ; Shin, EC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Continuous flow synthesis of aryl aldehydes by Pd-catalyzed formylation of phenol-derived aryl fluorosulfonates using syngas published in 2020.0. COA of Formula: C8H8O2, Reprint Addresses Hone, CA; Kappe, CO (corresponding author), Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria.; Hone, CA; Kappe, CO (corresponding author), Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

This communication describes the palladium-catalyzed reductive carbonylation of aryl fluorosulfonates (ArOSO2F) using syngas as an inexpensive and sustainable source of carbon monoxide and hydrogen. The conversion of phenols to aryl fluorosulfonates can be conveniently achieved by employing the inexpensive commodity chemical sulfuryl fluoride (SO2F2) and base. The developed continuous flow formylation protocol requires relatively low loadings for palladium acetate (1.25 mol%) and ligand (2.5 mol%). Good to excellent yields of aryl aldehydes were obtained within 45 min for substrates containing electron withdrawing substituents, and 2 h for substrates containing electron donating substituents. The optimal reaction conditions were identified as 120 degrees C temperature and 20 bar pressure in dimethyl sulfoxide (DMSO) as solvent. DMSO was crucial in suppressing Pd black formation and enhancing reaction rate and selectivity.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kockinger, M; Hanselmann, P; Hu, GX; Hone, CA; Kappe, CO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A Facile Approach to alpha-Keto Esters via Oxidative Esterification of alpha-Amino Carbonyl Compounds WOS:000478551000001 published article about GLYCINE DERIVATIVES; AEROBIC OXIDATION; ALCOHOLS; ACIDS; OXYGENATION; KETOESTERS; ARYLATION; PEPTIDES; AMIDES; ACETOPHENONES in [Wang, Yong-qiang; Zou, Jiao-xia; Peng, Xue; Lu, Ying-mei; Feng, Yi-yue; Chen, Chen; Shi, Tao; Wang, Zhen] Lanzhou Univ, Sch Pharm, West Donggang Rd 199, Lanzhou 730000, Gansu, Peoples R China; [Wang, Hui-hong; Wang, Zhen] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2019.0, Cited 62.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A direct oxidative esterification of alpha-amino carbonyl compounds by two kinds of hydroperoxides, for the synthesis of alpha-keto esters has been developed. The reaction shows broad substrates scope and good functional group tolerance, even for the synthesis of bulkyl esters, and is free of metal catalysts and external additives. Notably, the inhibitor of protein tyrosine phosphatases (PTPases) could be successfully synthesized with our protocol.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wang, YQ; Zou, JX; Wang, HH; Peng, X; Lu, YM; Feng, YY; Chen, C; Shi, T; Wang, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article General Paradigm in Photoredox Nickel-Catalyzed Cross-Coupling Allows for Light-Free Access to Reactivity published in 2020. Category: indole-building-block, Reprint Addresses Nocera, DG (corresponding author), Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 USA.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Self-sustained Ni-I/III cycles are established as a potentially general paradigm in photoredox Ni-catalyzed carbon-heteroatom cross-coupling reactions through a strategy that allows us to recapitulate photoredox-like reactivity in the absence of light across a wide range of substrates in the amination, etherification, and esterification of aryl bromides, the latter of which has remained, hitherto, elusive under thermal Ni catalysis. Moreover, the accessibility of esterification in the absence of light is especially notable because previous mechanistic studies on this transformation under photoredox conditions have unanimously invoked energy-transfer-mediated pathways.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Sun, R; Qin, YZ; Nocera, DG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Manickam, M; Pichaimani, P; Arumugam, H; Muthukaruppan, A in [Manickam, Manoj; Pichaimani, Prabunathan; Arumugam, Hariharan; Muthukaruppan, Alagar] PSG Inst Technol & Appl Res, Polymer Engn Lab, Coimbatore 641062, Tamil Nadu, India published Synthesis of Nontoxic Pyrazolidine-Based Benzoxazine-Coated Cotton Fabric for Oil-Water Separation in 2019.0, Cited 37.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In the present work, pyrazolidine bisphenol (PYBP)-based superhydrophobic/superoleophilic benzoxazine (PBz) matrices were synthesized and described in comparison with bisphenol F benzoxazines. The preliminary in vitro toxicity assay reveals the nontoxic nature of PYBP. Data obtained from thermal and surface studies indicate that the prepared PYBP-based PBzs have enhanced thermal stability than those of bisphenol F benzoxazines. Further, the prepared PYBP-based PBz-coated cotton fabric displayed superior water contact angle (WCA = 154.7 degrees) and sliding contact angle (theta = 9 degrees). Observations from SEM images suggest that the inherent superhydrophobic nature was due to the formation of rough surfaces. Furthermore, oil-water separation was successfully ascertained from the appropriate experimental conditions using the PYBP-coated fabric. The separation efficiency and flux are found to be greater than 90% after 10 cycles. Thus, the PYBP-based superhydrophobic/superoleophilic polybenzoxazines (PBzs) have been synthesized and characterized to assess their suitability for water-repellent and oil-water separation applications.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Manickam, M; Pichaimani, P; Arumugam, H; Muthukaruppan, A or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A new antifungal aminobenzamide derivative from the endophytic fungus Fusarium sp. WOS:000468924000005 published article about TETRACYCLIC TRITERPENOIDS; FUSARITHIOAMIDE; BUTYROLACTONES in [Ibrahim, Sabrin R. M.; Al Haidari, Rwaida A.; Zayed, Mohamed F.] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawwarah, Saudi Arabia; [Ibrahim, Sabrin R. M.] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Mohamed, Gamal A.] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah, Saudi Arabia; [Mohamed, Gamal A.] Al Azhar Univ, Assiut Branch, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Khayat, Maan T.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah, Saudi Arabia; [El-Kholy, Amal A.] Taibah Univ, Coll Pharm, Dept Clin & Hosp Pharm, Al Madinah Al Munawwarah, Saudi Arabia; [El-Kholy, Amal A.] Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt; [Zayed, Mohamed F.] Al Azhar Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt in 2019.0, Cited 17.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Background: Endophytic fungi attracted attention as a prolific source of bioactive natural products with a potent pharmaceutical activity and unique structure. Objective: The main goal of the study is to separate and identify the bioactive constituents from the endophytic fungus Fusarium sp. as well as to evaluate the antimicrobial of the new metabolites. Materials and Methods: The fungus was cultured on a rice medium, and then, the cultures were extracted with ethyl acetate (EtOAc). The EtOAc extract was chromatographed utilizing different chromatographic methods to give five metabolites. The structural determination of these metabolites was carried out by the analyses of various spectroscopic data, in addition to comparison with the formerly reported data. The antifungal and antibacterial potentials were evaluated toward various microbial strains using disc diffusion assay. Results: A new aminobenzamide derivative, namely fusaribenzamide A (2), and four known metabolites: (22E,24R)-stigmasta-5,7,22-trien-3–ol (1), adenosine (3), p-hydroxyacetophenone (4), and tyrosol (5) were isolated. Fusaribenzamide A (2) possessed significant antifungal activity toward Candida albicans with minimum inhibitory concentration (MIC) value 11.9 mg/disc compared to nystatin (MIC 4.9 mg/disc). Conclusion: The endophytic fungus Fusarium sp. could be considered as a wealthy pool for the isolation of aminobenzamide derivatives. Fusaribenzamide A may be a candidate for the discovery of a promising antifungal agent.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ibrahim, SRM; Mohamed, GA; Khayat, MT; Al Haidari, RA; El-Kholy, AA; Zayed, MF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles