Category: 99-93-4

Shen, ZY; Zhang, SL; Geng, HH; Wang, JR; Zhang, XY; Zhou, AQ; Yao, C; Chen, XB; Wang, W in [Shen, Zuyuan; Geng, Huihui; Wang, Jiarui; Zhang, Xinyu; Zhou, Anqi; Yao, Cheng; Chen, Xiaobei; Wang, Wei] East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Sch Pharm, Shanghai 200237, Peoples R China; [Shen, Zuyuan; Geng, Huihui; Wang, Jiarui; Zhang, Xinyu; Zhou, Anqi; Yao, Cheng; Chen, Xiaobei; Wang, Wei] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China; [Zhang, Shilei] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China; [Zhang, Shilei] Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China; [Wang, Wei] Univ Arizona, Dept Pharmacol & Toxicol, 1703 East Mabel St,POB 210207, Tucson, AZ 85721 USA; [Wang, Wei] Univ Arizona, BIO5 Inst, 1703 East Mabel St,POB 210207, Tucson, AZ 85721 USA published Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction in 2019, Cited 60. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d(6) is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d(6) and directly used for subsequent trideuteromethylation in a one-pot operation. The preparative power of the new versatile reagent and the one-pot protocol is demonstrated by its use to install the -CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Shen, ZY; Zhang, SL; Geng, HH; Wang, JR; Zhang, XY; Zhou, AQ; Yao, C; Chen, XB; Wang, W or concate me.. Recommanded Product: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Room-Temperature Ionic Liquids (RTILs) as Green Media for Metal- and Base-Free ipso-Hydroxylation of Arylboronic Acids published in 2019.0. Recommanded Product: 99-93-4, Reprint Addresses Kim, SH (corresponding author), Dankook Univ, Dept Chem, 119 Dandaero, Cheonan 31116, South Korea.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

The oxidative hydroxylation of arylboronic acids to the corresponding phenolic compounds under metal- and base-free aerobic conditions is successfully demonstrated on a greener media. Hydrogen peroxide, as an eco-friendly oxidant, is compatible with green mediates room-temperature ionic liquids (RTIL)s, providing hydroxylation products of arylboronic acids in an efficient manner. The RTIL support is particularly interesting for its reusability.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Shin, EJ; Kwon, GT; Kim, SH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Nickel-Mediated Trifluoromethylation of Phenol Derivatives by Aryl C-O Bond Activation published in 2020.0. COA of Formula: C8H8O2, Reprint Addresses Qing, FL (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Ctr Excellence Mol Sy, 345 Lingling Lu, Shanghai 200032, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

The increasing pharmaceutical importance of trifluoromethylarenes has stimulated the development of more efficient trifluoromethylation reactions. Tremendous efforts have focused on copper- and palladium-mediated/catalyzed trifluoromethylation of aryl halides. In contrast, no general method exists for the conversion of widely available inert electrophiles, such as phenol derivatives, into the corresponding trifluoromethylated arenes. Reported herein is a practical nickel-mediated trifluoromethylation of phenol derivatives with readily available trimethyl(trifluoromethyl)silane (TMSCF3). The strategy relies on PMe3-promoted oxidative addition and transmetalation, and CCl3CN-induced reductive elimination. The broad utility of this transformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic and heteroaromatic systems, including biorelevant compounds.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Hu, WQ; Pan, S; Xu, XH; Vicic, DA; Qing, FL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. Caceres-Castillo, D; Carballo, RM; Quijano-Quinones, R; Miron-Lopez, G; Graniel-Sabido, M; Moo-Puc, RE; Mena-Rejon, GJ in [Caceres-Castillo, David; Carballo, Ruben M.; Quijano-Quinones, Ramiro; Miron-Lopez, Gumersindo; Graniel-Sabido, Manlio; Mena-Rejon, Gonzalo J.] Univ Autonoma Yucatan, Fac Quim, C 43 613, Merida 97069, Yucatan, Mexico; [Moo-Puc, Rosa E.] Ctr Med Ignacio Garcia Tellez, Unidad Med Alta Especialidad, Unidad Invest Med Yucatan, IMSS, C 41,439, Merida 97150, Yucatan, Mexico published Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones in 2020.0, Cited 29.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were synthesized using microwave-assisted Claissen-Smichdt condensation and evaluated for their activity against Giardia lamblia and Green monkey kidney cells. Five compounds exhibited activity against G. lamblia at IC50’s 3m exhibited the highest antigiardial activity (IC50 = 1.03 mu M), even more than the positive control (metronidazole, IC50 = 1.4 mu M), and selectivity (SI = 38.9). A preliminary SAR study suggested that electrophylicity has not relationship with antigiardiasic activity, and the docking study reveals that synthesized chalcones bind at zone 3 of colchicine site, therefore presumably the action mechanism of the synthesized chalcones does not follow the Michael acceptor mechanism.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Caceres-Castillo, D; Carballo, RM; Quijano-Quinones, R; Miron-Lopez, G; Graniel-Sabido, M; Moo-Puc, RE; Mena-Rejon, GJ or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties WOS:000469157200005 published article about NAIL PSORIASIS; NATURALIS OINTMENT; OBSERVER-BLIND; EFFICACY; EXTRACT; SAFETY in [Lee, Chia-Lin] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Lee, Chia-Lin; Wu, Yang-Chang] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan; [Lee, Chia-Lin; Wang, Chien-Ming; Yen, Hung-Rong; Song, Ying-Chyi; Yu, Sheng-Jie] China Med Univ, Chinese Med Res Ctr, Taichung 40402, Taiwan; [Hu, Hao-Chun; Wu, Yang-Chang] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan; [Yen, Hung-Rong] China Med Univ, Grad Inst Chinese Med, Sch Chinese Med, Coll Chinese Med, Taichung 40402, Taiwan; [Yen, Hung-Rong] China Med Univ Hosp, Dept Chinese Med, Taichung 40447, Taiwan; [Yen, Hung-Rong; Song, Ying-Chyi; Yu, Sheng-Jie] China Med Univ Hosp, Dept Med Res, Res Ctr Tradit Chinese Med, Taichung 40447, Taiwan; [Chen, Chao-Jung] China Med Univ, Grad Inst Integrated Med, Taichung 40402, Taiwan; [Chen, Chao-Jung] China Med Univ Hosp, Dept Med Res, Prote Core Lab, Taichung 40447, Taiwan; [Li, Wei-Chu] Sheng Chang Pharmaceut Co, Taoyuan 32050, Taiwan in 2019.0, Cited 19.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent in moderate psoriasis, targeting interleukin-17 (IL-17). In this study, it was prepared from the aerial parts of Strobilanthes cusia. Three undescribed indole alkaloid derivatives, indigodoles A-C, along with seven known compounds were isolated from this preparation of Qing Dai and their structures were elucidated from spectroscopic data, including NMR, MS, UV, IR, optical rotation, and CD. As well, most compounds were tested against IL-17. Indigodole C and tryptanthrin could significantly inhibit IL-17 production of Th17 cells. In addition, indigodole A and indirubin showed notably anti-IL-17 gene expression in dose-dependent effects without cytotoxicities toward Th17 and Jurkat cells, respectively. Overall, our studies indicate that the aforementioned indole alkaloids could contribute to anti-IL 17 properties of Qing Dai.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Lee, CL; Wang, CM; Hu, HC; Yen, HR; Song, YC; Yu, SJ; Chen, CJ; Li, WC; Wu, YC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 99-93-4. Recently I am researching about DISCOVERY; DESIGN; POTENT; STAPHYLOCOCCI; OPTIMIZATION; IV, Saw an article supported by the National Research Centre (NRC) – Cairo – EgyptNational Research Centre (NRC) [AR110218]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ghannam, IAY; Abd El-Meguid, EA; Ali, IH; Sheir, DH; El Kerdawy, AM. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A series of new 2-arylbenzothiazole derivatives (4, 5, 6a-j, 7a-i and 8a,b) was synthesized and tested for their antimicrobial activity against different Gram-positive, Gram-negative bacteria and yeast using ciprofloxacin and fluconazole as positive controls for the antibacterial and antifungal activities, respectively. The target compounds showed stronger inhibitory activity against Gram-negative than Gram-positive bacteria. The minimum inhibitory concentration (MIC) values were determined for those compounds showed zone of inhibition >= 13 mm. Based on the MIC values for the tested compounds against E. coli, compounds (4, 5, 6c, 6d, 6g, 6i, 6j, 7b, 7c, 7g and 8a) were selected and tested for their E. coli gyrase inhibitory activity. The tested compounds showed moderate inhibitory activity against E. coli gyrase. Compounds 5, 6c, 6i, 6j and 7b displayed high inhibitory activity against E. coli gyrase with IC50 values below 10 mu M, however, they were less active than ciprofloxacin (E. coli gyrase IC50 = 1.14 mu M). The p-hydroxy-m-methoxy benzothiazole analogue 6c was the most active tested compound (E. coli gyrase IC50 = 4.85 mu M). Quantitative structure-activity relationship (QSAR) study was also implemented for the newly synthesized compounds. The QSAR study indicated that the structural feature that governs the anti-microbial activity for the newly synthesized benzothiazole derivatives is their structural hydrophilic-lipophilic balance what agrees with the chemical intuition where this balance governs their cellular absorption and so their antimicrobial activity. Molecular docking showed that the newly synthesized compounds possess the required structural feature for E. coli gyrase B inhibition through interaction with the key amino acids Asp73 and Gly77.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ghannam, IAY; Abd El-Meguid, EA; Ali, IH; Sheir, DH; El Kerdawy, AM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates WOS:000489963500010 published article about DIHYDROFOLATE-REDUCTASE INHIBITORS; ONE-POT PREPARATION; 2-SUBSTITUTED BENZIMIDAZOLES; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; DHFR INHIBITORS; DESIGN; DERIVATIVES; RESISTANT in [Harer, Sunil] Savitribai Phule Pune Univ, Sharadchandra Pawar Coll Pharm, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Pune 412409, Maharashtra, India; [Bhatia, Manish; Kawade, Vikram] Shivaji Univ, Bharati Vidyapeeth Coll Pharm, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Kolhapur, Maharashtra, India in 2019.0, Cited 49.0. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Background: Dihydrofolate reductase is one of the important enzymes for thymidylate and purine synthesis in micro-organisms. A large number of drugs have been designed to inhibit microbial DHFR but over the period of time some drugs have developed resistance and cross reactivity towards the enzyme. Over the past few decades, benzimidazoles, triazoles and their derivatives have been grabbing the attention of the synthetic chemists for their wide gamut of antibacterial and antifungal activities targeting microbial protein DHFR. Objective: Our goal behind present investigation is to explore benzimidazoles class of drugs as microbial DHFR inhibitors by studying ligand-receptor binding interactions, in vitro enzyme inhibition assay and confirmation of anti-microbial activity against selected pathogenic micro-organisms. Method: A library containing thirty novel 2,6-disubstituted 1H-benzimidazoles was synthesized by one pot condensation of o-nitro aniline or 2,4-dinitro aniline with series of aldehydes or acetophenones using Na2S2O4 or SnCl2 respectively and reflux for 5-6hr. Structures of compounds have been confirmed by spectroscopic methods as 1H and C-13 NMR, FT-IR and MS. In vitro DHFR inhibition study was performed by using Epoch microplate reader and IC50 of the test compounds was compared with Trimethoprim. In vitro antimicrobial activity was performed against selected clinical pathogens by agar disk diffusion method and MIC (mu g/mL) was reported. Results: Moderate to good level of DHFR inhibition was observed with IC50 values in the range of 7-23 mu M. Compounds B1, B19, B22, B24 and B30 has expressed 1.1 to 1.4 folds more prominent DHFR inhibitory activity as compared to standard Trimethoprim. Remarkable antimicrobial activity was exhibited by B1, B19, B22, B24 and B30. Molecular docking study has revealed perfect binding of test ligands with key amino acids of DHFR as Phe31, Ile94, Ile5, Asp27, Gln32 and Phe36. Conclusion: Nature of 1H-benzimidazole substituents at position 2 and 6 had influence over magnitude and type of molecular binding and variation in the biological activity. Present series of 1H-benzimidazoles could be considered promising broad-spectrum antimicrobial candidates that deserve in future for preclinical antimicrobial evaluation and development of newer antimicrobial agents targeting microbial DHFR.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Harer, S; Bhatia, M; Kawade, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G in [Munoz, Antonio; Orcajo, Gisela; Calleja, Guillermo] Rey Juan Carlos Univ, Dept Chem Energy & Mech Technol, C Tulipan S-N, Mostoles 28933, Spain; [Leo, Pedro; Martinez, Fernando] Rey Juan Carlos Univ, Dept Chem & Environm Technol, C Tulipan S-N, Mostoles 28933, Spain published URJC-1-MOF as New Heterogeneous Recyclable Catalyst for C-Heteroatom Coupling Reactions in 2019, Cited 41. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Guillermo Calleja and co-workers from @urjc describe URJC-1-MOF as a new heterogeneous recyclable catalyst for c-heteroatom coupling reactions The capacity of copper-based URJC-1-MOF as a MOF catalyst in cross-coupling reactions has been evaluated, focusing on the Chan-Lam-Evans arylation-type reactions on amines and alcohols without extra additives or ligands. The extraordinary chemical and structural stability of URJC-1-MOF and its good specific surface, make this material a promising alternative to homogeneous Cu (II) catalysts for cross-coupling reactions. URJC-1-MOF showed a remarkable catalytic activity for cross-coupling C-N and C-O reactions, higher than other heterogeneous and homogeneous copper-based catalyst, such as CuO, HKUST-1, Cu-MOF-74, Cu(OAc)(2) and CuSO4.5H(2)O. Moreover, its easy recovery by simple filtration and reusability in successive runs without any loss of activity and stability, demonstrates the potential of URJC-1-MOF as an alternative catalyst for this kind of reactions in different chemical media of industrial interest.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Safabakhsh, T; Daraei, H; Saha, N; Khodakarim, S in DESALINATION PUBL published article about AZO-DYE; REMOVAL; OXIDATION; MECHANISM; PEROXYMONOSULFATE; KINETICS in [Safabakhsh, Tahereh] Isfahan Univ Med Sci, Int Educ Ctr, Esfahan, Iran; [Daraei, Hasti] Shahid Beheshti Univ Med, Sch Publ Hlth & Safety, Student Res Comm, Tehran, Iran; [Saha, Narottam] Univ Queensland, Sustainable Minerals Inst, Ctr Mined Land Rehabil, Brisbane, Qld, Australia; [Khodakarim, Soheila] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Epidemiol, Tehran, Iran in 2019.0, Cited 28.0. Computed Properties of C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The present study investigated the degradation of bisphenol A (BPA) from aqueous solution using Fe3O4/persulfate process. The effects of pH (3, 5, 7 and 11), persulfate (PS) concentrations (1, 2, 5 and 10 mM), Fe3O4 magnetic nanoparticle doses (0.5, 1, 1.5 and 2 g/L), and contact time (5, 10, 20 and 30 min) on BPA removal were examined. The effect of all factors was significant (p < 0.05), and the optimal conditions were: pH value of 3, Fe3O4 dose of 2 g/L, BPA concentration of 0.1 mg/L, and contact time of 30 min. The BPA removal efficiency under optimal conditions was 98%. The results of this work indicate that Fe3O4 nanoparticles can be used as an effective catalyst and adsorbent for the removal of BPA from water and industrial wastewater. Analysis of by-products of BPA using GC-MS detected the presence of compounds with lower molecular weights (4-hydroxyacetophenone, 4-isopropenylphenol, benzoquinone and succinic acid) relative to BPA. Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Safabakhsh, T; Daraei, H; Saha, N; Khodakarim, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 EUR J ORG CHEM published article about OXIDATIVE TRIFLUOROMETHYLATION; H TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; AROMATIC-COMPOUNDS; LACCASE; ARENES; FLUORINE; REAGENT; HETEROARENES; REACTIVITY in [Pletz, Jakob; Koeberl, Christoph; Fuchs, Michael; Kroutil, Wolfgang] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, BioTechMed Graz, Heinrichstr 28, A-8010 Graz, Austria; [Steiner, Oliver; Goessler, Walter] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Univ Pl 1-1, A-8010 Graz, Austria in 2019.0, Cited 54.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. HPLC of Formula: C8H8O2

Fluorination and trifluoromethylation are indispensable tools in the preparation of modern pharmaceuticals and APIs. Herein we present a concept for the introduction of a trifluoromethyl group into unprotected phenols employing catalytic copper(I) iodide and hydroquinone, tBuOOH, and the Langlois’ reagent. The method proceeds under mild conditions and exhibits an extended substrate scope compared to the biocatalytic trifluoromethylation using laccase from Agaricus bisporus. Various functional groups such as aldehydes, esters, ethers, ketones and nitriles were tolerated. The hydroquinone-mediated trifluoromethylation reaction allowed accessing trifluoromethylated phenols, which are cumbersome to prepare via previously known chemical methods.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Pletz, J; Koeberl, C; Fuchs, M; Steiner, O; Goessler, W; Kroutil, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles