《Trisulfonamide calix[6]arene-catalysed Michael addition to nitroalkenes》 was written by Cera, Gianpiero; Balestri, Davide; Bazzoni, Margherita; Marchio, Luciano; Secchi, Andrea; Arduini, Arturo. Quality Control of 5-Fluoro-1H-indole And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
The application of a novel family of trisulfonamide (TSA) calix[6]arenes I in general acid catalysis was described. Hydrogen-bonding interactions between acidic TSA and methanol boosted the reactivity of the Michael addition of indoles II (R = H, Me; R1 = H, F, Br, OH, OMe) to nitroalkene derivatives 3-R2-4-R3-C6H3CH=CHNO2 (R2 = H, OMe; R3 = H, Me, Br, Cl, OMe). The transformation occurs at a low catalyst loading of 5 mol%, allowing for the synthesis of nitroalkanes III with good yields and functional group tolerance. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Quality Control of 5-Fluoro-1H-indole)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Quality Control of 5-Fluoro-1H-indole
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles