On March 10, 2005, Chang, Hye-Kyung; Oh, Yeong-Koo; Park, Cheol-Won; Jang, Yong-Jin; Park, Tae-Kyo; Kim, Sung-Sub; Kim, Min-Jung; Park, Mi-Jeong; Park, Jung-Gyu; Park, Hee-Dong; Min, Kyeong-sik; Lee, Tae-soo; Lee, Sang-kyun; Kim, Soo-hyeon; Jeong, Hee-kyung; Lee, Sun-hwa; Kim, Hwa-dong; Kim, Ae-ri; Park, Ki-sook; Shin, Hyun-ik; Choi, Hyeong-wook; Lee, Kyu-woong; Lee, Jae-hoon; Heo, Tae-ho; Kim, Ho-jun; Kwon, Tae-sik published a patent.HPLC of Formula: 883526-76-9 The title of the patent was Preparation of carbamoylisoxazoles as caspase inhibitors. And the patent contained the following:
Isoxazoles I [R = H, alkyl, cycloalkyl, aryl, aralkyl; R1 = alkyl, cycloalkyl, aryl, aralkyl, amino acid residue; R2 = alkyl, cycloalkyl, aryl, aralkyl, amino acid residue, H, substituted hydroxyalkyl; A = bond, O alkylene, oxaalkylene, (un)substituted NH2; B = H, alkyl, cycloalkyl, aralkyl; CRR1 = carbocyclic or heterocyclic ring; X = acyl, substituted CH:CHCOH, CH:CHSO2H] were prepared for use as caspase inhibitors in the prevention of inflammation and apoptosis. Thus, PhCCl:NOH was treated with CH2:CEtCO2Et ti give Et 5-ethyl-3-phenyl-4,5-dihydro-5-isoxazolecarboxylate (II). Tert.-Bu (3S)-3-amino-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate (III) was prepared from 2,3,5,6-F4CHOH and N-benzyloxycarbonyl-L-aspartic acid β-tert.-Bu ester. Amidation of III with II and deblocking gave the title compound IV which had Ki for caspase inhibition of 1.9 M-1 min-1. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9
The Article related to carbamoylisoxazole preparation caspase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.HPLC of Formula: 883526-76-9
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles