Recommanded Product: 6-Methoxyisoindolin-1-oneIn 2021, Chang, Zhe;Huang, Jialin;Wang, Si;Chen, Geshuyi;Zhao, Heng;Wang, Rui;Zhao, Depeng published 《Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles》. 《Nature Communications》published the findings. The article contains the following contents:
A copper-catalyzed late-stage C(sp3)-H functionalization of N-heterocycles using com. available catalysts under mild reaction conditions was reported. We have investigated eight types of N-heterocycles such as I (R = H, Me) which were usually found in medicinally important skeletons. The scope and utility of this approach were demonstrated by late-stage C(sp3)-H modification of these heterocycles including a number of pharmaceuticals with a broad range of nucleophiles, such as methylation, arylation, azidination, mono-deuteration, and glycoconjugation. Preliminary mechanistic studies revealed that the reaction undergoes a C-H fluorination process which is followed by a nucleophilic substitution. To complete the study, the researchers used 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Recommanded Product: 6-Methoxyisoindolin-1-one) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles