Chang, Zhe published the artcileCopper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles, Formula: C8H6ClNO, the main research area is functionalized nitrogen heterocycle preparation; nitrogen heterocycle functionalization copper catalyst.
A copper-catalyzed late-stage C(sp3)-H functionalization of N-heterocycles using com. available catalysts under mild reaction conditions was reported. We have investigated eight types of N-heterocycles such as I (R = H, Me) which were usually found in medicinally important skeletons. The scope and utility of this approach were demonstrated by late-stage C(sp3)-H modification of these heterocycles including a number of pharmaceuticals with a broad range of nucleophiles, such as methylation, arylation, azidination, mono-deuteration, and glycoconjugation. Preliminary mechanistic studies revealed that the reaction undergoes a C-H fluorination process which is followed by a nucleophilic substitution.
Nature Communications published new progress about Alkylation. 74572-29-5 belongs to class indole-building-block, name is 5-Chloroisoindolin-1-one, and the molecular formula is C8H6ClNO, Formula: C8H6ClNO.
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles