Recommanded Product: 4′-Hydroxyacetophenone. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study published in 2019.0, Reprint Addresses Saghaie, L (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Med Chem, Esfahan 8174673461, Iran.; Mahdavi, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Endocrinol & Metab Res Ctr, Tehran 1417653761, Iran.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.
In this work, two novel series of indole-thiosemicarbazone derivatives were designed, synthesized, and evaluated for their cytotoxic activity against MCF-7, A-549, and Hep-G2cell lines in comparison to etoposide and colchicine as the reference drugs. Generally, the synthesized compounds showed better cytotoxicity towards A-549 and Hep-G2 than MCF-7. Among them, (2E)-2-{[2-(4-chlorophenyl)-1H-indol-3-yl]methylidene}-N-(4-methoxyphenyl)hydrazinecarbothioamide (8l) was found to be the most potent compound against A-549 and Hep-G2, at least three times more potent than etoposide. The morphological analysis by the acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that compound 8l induced apoptosis in A-549 cells. Moreover, molecular docking methodology was exploited to elucidate the details of molecular interactions of the studied compounds with putative targets.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bakherad, Z; Safavi, M; Fassihi, A; Sadeghi-Aliabadi, H; Bakherad, M; Rastegar, H; Saeedi, M; Ghasemi, JB; Saghaie, L; Mahdavi, M or concate me.. Recommanded Product: 4′-Hydroxyacetophenone
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles