Application In Synthesis of 4-Methoxybenzaldehyde. Authors Hussein, AHM; Khames, AA; El-Adasy, AA; Atalla, AA; Abdel-Rady, M; Hassan, MIA; Abou-Salim, MA; Elshaier, YAMM; Barakat, A in MDPI published article about in [Hussein, Abdel Haleem M.; Khames, Ahmed A.; El-Adasy, Abu-Bakr A.; Atalla, Ahmed A.] Al Azhar Univ, Dept Chem, Fac Sci, Assiut 71524, Egypt; [Abdel-Rady, Mohamed] Assiut Univ, Dept Chem, Fac Sci, Assiut 71516, Egypt; [Hassan, Mohamed I. A.] Al Azhar Univ, Dept Pharmacol & Toxicol, Fac Pharm, Assiut 71524, Egypt; [Abou-Salim, Mahrous A.] Al Azhar Univ, Dept Pharmaceut Organ Chem, Fac Pharm, Assiut 71524, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Dept Organ & Med Chem, Fac Pharm, Menoufia 32958, Egypt; [Barakat, Assem] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia; [Barakat, Assem] Alexandria Univ, Dept Chem, Fac Sci, Alexandria 21321, Egypt in 2021, Cited 34. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
The elaboration of new small molecules that target phosphodiesterase enzymes (PDEs), especially those of type 5 (PDE5), is an interesting and emerging topic nowadays. A new series of heterocycle-based aminothiazoles were designed and synthesized from the key intermediate, 3-oxo-N-(thiazol-2-yl)butanamide (a PDE5 inhibitor that retains its amidic function), as an essential pharmacophoric moiety. The PDE5 inhibitors prevent the degradation of cyclic guanosine monophosphate, thereby causing severe hypotension as a marked side effect. Hence, an in vivo testing of the target compounds was conducted to verify its relation with arterial blood pressure. Utilizing sildenafil as the reference drug, Compounds 5, 10a, and 11b achieved 100% inhibitions of PDE5 without significantly lowering the mean arterial blood pressures (115.95 +/- 2.91, 110.3 +/- 2.84, and 78.3 +/- 2.57, respectively). The molecular docking study revealed that the tested compounds exhibited docking poses that were similar to that of sildenafil (exploiting the amide functionality that interacted with GLN:817:A). The molecular shape and electrostatic similarity revealed a comparable physically achievable electrostatic potential with the reference drug, sildenafil. Therefore, these concomitant results revealed that the tested compounds exerted sildenafil-like inhibitory effects (although without its known drawbacks) on blood circulation, thus suggesting that the tested compounds might represent a cornerstone of beneficial drug candidates for the safe treatment for erectile dysfunction.
Application In Synthesis of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Hussein, AHM; Khames, AA; El-Adasy, AA; Atalla, AA; Abdel-Rady, M; Hassan, MIA; Abou-Salim, MA; Elshaier, YAMM; Barakat, A or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles