HPLC of Formula: C7H8O2. I found the field of Pharmacology & Pharmacy very interesting. Saw the article The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type published in 2019.0, Reprint Addresses Moon, HR (corresponding author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea.; Chun, P (corresponding author), Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea.; Chun, P (corresponding author), Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol.
In order to investigate the effect of the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type on tyrosinase inhibition, 2-phenyl-1,4-naphthoquinone derivatives were synthesized by Michael addition of substituted benzenes to 1,4-naphthoquinone and subsequently an auto-oxidation. Most of the derivatives potently inhibited mushroom tyrosinase and four derivatives, including 1c (IC50=22.00 +/- 1.63M), more potently inhibited mushroom tyrosinase than kojic acid (IC50=37.86 +/- 2.21M). Cell-based assays using B16F10 cells (a melanoma cell line) showed 1c dose-dependently suppressed melanin production and more potently inhibited tyrosinase activity than kojic acid. Docking simulation results between 1c and tyrosinase and a kinetic study suggest that 1c is a competitive inhibitor that binds to the active site of tyrosinase. These results support that anti-melanogenic effect of naphthoquinone derivatives results from their tyrosinase inhibiting activity and the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type can confer tyrosinase-inhibitory activity.
About m-Methoxyphenol, If you have any questions, you can contact Ullah, S; Akter, J; Kim, SJ; Yang, J; Park, Y; Chun, P; Moon, HR or concate me.. HPLC of Formula: C7H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles