Murugesh, V; Sahoo, AR; Achard, M; Sharma, GVM; Bruneau, C; Suresh, S in [Murugesh, V; Sharma, Gangavaram V. M.; Suresh, Surisetti] CSIR Indian Inst Chem Technol CSIR IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India; [Murugesh, V; Suresh, Surisetti] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India; [Sahoo, Apurba Ranjan; Achard, Mathieu; Bruneau, Christian] Univ Rennes, ISCR Inst Sci Chim Rennes, CNRS, UMR 6226, F-35000 Rennes, France published Ruthenium Catalyzed Regioselective beta-C(sp(3))-H Functionalization of N-Alkyl-N ‘-p-nitrophenyl Substituted Piperazines using Aldehydes as Alkylating Agents in 2021, Cited 58. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Herein, we disclose a ruthenium-catalyzed regioselective beta-C(sp(3))-H bond functionalization on the piperazine core using aldehydes as alkylating agents. The present transformation appears to go through the dehydrogenation of the piperazine to propagate to enamine in situ, followed by nucleophilic addition to the aldehyde and hydrogenation to result in the regioselective beta-C(sp(3))-H alkylation. A variety of aromatic, heteroaromatic, aliphatic aldehydes were employed for the C-3 alkylation of N-alkyl-N ‘-p-nitrophenyl substituted piperazines.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles